NK cell lymphoma, nasal type, with massive lung involvement: a case report

Morović, Anamarija; Aurer, Igor; Dotlić, Snježana; Weisenburger, Dennis D.; Nola, Marin

doi:10.1007/s12308-009-0050-z

Cited by 8 publications

(5 citation statements)

References 17 publications

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“…Morovic et al reported a case of nasal NK/ T-cell lymphoma with secondary lung involvement, despite aggressive chemotherapy and intensive supportive treatment, the patient died shortly after the initiation of therapy. 31 In conclusion, despite the rarity of NK/T-cell lymphoma it is important for otolaryngologists and ophthalmologists to consider ocular involvement and distant metastases. The present case demonstrates that nasal NK/T-cell lymphoma can occur intraocular and widely disseminate aggressively with a poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

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Bilateral intraocular and lung involvements associated with Nasal NK/T-cell lymphoma

Wang

Jia

Zhang

et al. 2022

European Journal of Ophthalmology

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Background To report a rare case of nasal natural killer/T (NK/T) cell lymphoma with bilateral intraocular and lung metastasis and to further describe the clinical features of intraocular manifestations. Case presentation A 54-year-old man presented with a 3-month history of left nasal congestion, and bilateral vision impairment of one week duration. Subsequent maxillary computed tomography (CT) and multiple biopsies confirmed the diagnosis of nasal NK/T-cell lymphoma. EBV-encoded small RNA (EBER) in situ hybridization revealed EBV infection. A comprehensive ophthalmic examination found lymphoma-associated retinopathy and choroidopathy, which presented as bilateral diverse patterns and retinal detachment. In addition, the chest CT showed multiple scattered nodules in both lungs, and soft-tissue mass in the left hilum with mediastinal and axillary lymphadenopathy. The condition of this patient deteriorated rapidly and he died shortly after diagnosis. Conclusions The rarity of secondary ocular NK/T-cell lymphoma makes it challenging to identify these tumors early. Both otolaryngologist and ophthalmologists should be aware of ocular involvement and other secondary manifestations of NK/T-cell lymphoma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Bilateral intraocular and lung involvements associated with Nasal NK/T-cell lymphoma

Wang

Jia

Zhang

et al. 2022

European Journal of Ophthalmology

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“…A PubMed search for case reports since 2000 using the keywords "primary pulmonary NK/T-cell lymphoma" yielded 18 case reports written in English (case reports written in Chinese were excluded) (Table 2) [8][9][10][11][12][13][14][15].…”

Section: Discussionmentioning

confidence: 99%

Successful Diagnosis by Video-Assisted Thoracoscopic Surgical Lung Biopsy in a Case of Progressive Primary Pulmonary Extranodal Natural Killer/T-cell Lymphoma, Nasal Type: A Case Report

Anai¹,

Gushiken²,

Chinen³

et al. 2023

Cureus

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Malignant pulmonary lymphoma is very rare and the majority of which are B-cell lymphomas. Since primary pulmonary extranodal natural killer (NK)/T-cell lymphoma, nasal type (ENKL) is difficult to diagnose and associated with poor prognosis and aggressive course, some cases are diagnosed at the postmortem autopsy. We report a case of a 53-year-old man with primary pulmonary ENKL diagnosed by video-assisted thoracoscopic surgery (VATS) lung biopsy. This case explains the importance of VATS lung biopsy and indepth evaluation, including flow cytometry, chromosome, genetic, and immunostaining tests, when primary pulmonary malignant lymphoma is suspected.

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“…However, it can also occur at extranasal sites (the skin, liver, spleen, gastrointestinal tract, bone marrow, lung, and so on). A primary presentation of ENKTCL in the lung and ENKTCL involving only the lung is rare ( 1 2 ). Furthermore, there is no report which primary pulmonary ENKTCL is presented with ground glass opacities (GGOs).…”

Section: Introductionmentioning

confidence: 99%

Primary Pulmonary Extranodal Natural Killer/T-cell Lymphoma, Nasal Type Presenting as Diffuse Ground Glass Opacities: a Case Report

et al. 2017

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Extranodal natural killer (NK)/T-cell lymphoma, nasal type (ENKTCL) is a rare type of lymphoma that accounts for only 5%–18% of all cases of non-Hodgkin lymphoma (NHL). In published series, 60%–90% of NK/T-cell lymphomas are localized to the nasal and upper airway. We describe a 55-year man who presented with cough, sputum, dyspnea on exertion, and a chest computed tomography scan shows diffuse ground glass opacities (GGOs), suggestive of an interstitial lung disease. He was treated with a corticosteroid and his symptoms improved. However, when the corticosteroid was tapered, his symptoms recurred. The patient underwent a surgical lung biopsy and ENKTCL was diagnosed. We present this case because ENKTCL involving only the lung is very rare but very informative. To our knowledge, our patient is the first case that primary pulmonary ENKTCL is presented with GGOs.

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NK cell lymphoma, nasal type, with massive lung involvement: a case report

Cited by 8 publications

References 17 publications

Bilateral intraocular and lung involvements associated with Nasal NK/T-cell lymphoma

Bilateral intraocular and lung involvements associated with Nasal NK/T-cell lymphoma

Successful Diagnosis by Video-Assisted Thoracoscopic Surgical Lung Biopsy in a Case of Progressive Primary Pulmonary Extranodal Natural Killer/T-cell Lymphoma, Nasal Type: A Case Report

Primary Pulmonary Extranodal Natural Killer/T-cell Lymphoma, Nasal Type Presenting as Diffuse Ground Glass Opacities: a Case Report

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