NK cells and interferons

Paolini, Rossella; Bernardini, Giovanni; Molfetta, Rosa; Santoni, Angela

doi:10.1016/j.cytogfr.2014.11.003

Cited by 119 publications

(93 citation statements)

References 108 publications

(137 reference statements)

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“…We note that administration of VIS410 is associated with an increase in IFN-γ. Elevation of IFN-γ has been associated with a significant protective antiviral effect and is likely one of the mechanisms by which VIS410 offers protection (13,14). Additionally, when VIS410 was coadministered with oseltamivir, mean IFN-γ, MIP-1α, and IP-10 levels were significantly lower compared with mock-treated mice (P < 0.05) and KC trended toward significance (P < 0.10).…”

Section: Resultsmentioning

confidence: 86%

A broadly neutralizing human monoclonal antibody is effective against H7N9

Tharakaraman

Subramanian

Viswanathan

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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Emerging strains of influenza represent a significant public health threat with potential pandemic consequences. Of particular concern are the recently emerged H7N9 strains which cause pneumonia with acute respiratory distress syndrome. Estimates are that nearly 80% of hospitalized patients with H7N9 have received intensive care unit support. VIS410, a human antibody, targets a unique conserved epitope on influenza A. We evaluated the efficacy of VIS410 for neutralization of group 2 influenza strains, including H3N2 and H7N9 strains in vitro and in vivo. VIS410, administered at 50 mg/kg, protected DBA mice infected with A/Anhui/2013 (H7N9), resulting in significant survival benefit upon single-dose (−24 h) or double-dose (−12 h, +48 h) administration (P < 0.001). A single dose of VIS410 at 50 mg/kg (−12 h) combined with oseltamivir at 50 mg/kg (−12 h, twice daily for 7 d) in C57BL/6 mice infected with A/Shanghai 2/2013 (H7N9) resulted in significant decreased lung viral load (P = 0.002) and decreased lung cytokine responses for nine of the 11 cytokines measured. Based on these results, we find that VIS410 may be effective either as monotherapy or combined with antivirals in treating H7N9 disease, as well as disease from other influenza strains.

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Section: Resultsmentioning

confidence: 86%

A broadly neutralizing human monoclonal antibody is effective against H7N9

Tharakaraman

Subramanian

Viswanathan

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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“…Результаты экспериментальных исследований показали, что IL-17-дефицитные мыши более вос-приимчивы к бактериальным инфекционным аген-там, в том числе и Staphylococcus aureus, чем мыши дикого типа [67,77,84]. Nathan K. Archer и соавт.…”

Section: Il-17аunclassified

Розвиток Імунної Відповіді При Стафілококовій Пневмонії (Частина 3)

Абатуров¹,

Никулина²

2021

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У даній статті на підставі літературних даних проаналізовано ключову роль прозапальних і протизапальних цитокінів у розвитку імунної відповіді при пневмонії, викликаної Staphylococcus aureus. Наведено гени, що асоційовані зі схильністю до стафілококової інфекції та/або визначають її. Описано сигнальні шляхи, що індукують продукцію інтерферонів І, ІІ і ІІІ типу, які беруть участь в елімінації Staphylococcus aureus.

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“…Natural killer (NK) cells are of lymphoid origin and serve key roles in the elimination of host viral infections in addition to tumor cell development which account for the majority of the liver innate immune cells (17,18). NK cells are known to secrete cytokines, including interferon-γ (IFN-γ) in response to stimulation (19). This regulation by cytokines has formed the basis of a number of different therapeutic approaches to activate NK cells using the infusion of allogeneic haploidentical NK donor cells to treat cancer (20)(21)(22).…”

Section: Introductionmentioning

confidence: 99%

Role of natural killer cells in liver transplantation treatment of liver cancer

Jin

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. Liver cancer caused by diet or life style is a significant public health problem. Liver transplantation (LT) is a commonly used method of treatment for the liver cancer. The present study aimed to determine whether assessing the net state of natural killer (NK) cell function following LT distinguishes patients at risk for transplantation rejection. A total of 53 patients were involved; all underwent LT for hepatocellular carcinoma with (n=13) or without (n=40) transplantation rejection. The density of interferon-γ (IFN-γ) in blood serum was examined and patients were divided into two groups: Higher (H) and lower (L), on the basis of IFN-γ density. The percentage of NK cells and their producing cytokines was detected using fluorescence-activated cell sorting in peripheral blood and liver samples. As evaluation indexes of liver function, aspartate transaminase (AST) and alanine transaminase (ALT) were detected in blood serum. NK cell activation of the H-group was observed to be higher than the L-group, specifically the expression of NK group 2D, cluster of differentiation 69 and IFN-γ were higher than the L-group. The H-group exhibited a higher level of AST and ALT, which indicates the potential for acute transplantation rejection. The results of the present study indicate that NK cells and NK-derived IFN-γ serve an important function in regulating the rejection of LT and tumor metastasis in response to LT.

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NK cells and interferons

Cited by 119 publications

References 108 publications

A broadly neutralizing human monoclonal antibody is effective against H7N9

A broadly neutralizing human monoclonal antibody is effective against H7N9

Розвиток Імунної Відповіді При Стафілококовій Пневмонії (Частина 3)

Role of natural killer cells in liver transplantation treatment of liver cancer

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