NK Cells Are Required for Dendritic Cell–Based Immunotherapy at the Time of Tumor Challenge

Bouwer, Anthea L.; Saunderson, Sarah C.; Caldwell, Felicity Jane; Damani, Tanvi; Pelham, Simon J.; Dunn, Amy C.; Jack, Ralph W.; Stoitzner, Patrizia; McLellan, Alexander D.

doi:10.4049/jimmunol.1202797

Cited by 48 publications

(44 citation statements)

References 58 publications

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“…55 This innate cross talk can further impact adaptive responses, as evidenced by the reduced benefit of DC vaccination after NK cell depletion in a melanoma mouse model. 56 Both soluble (IFN-g) as well as contact-dependent (OX40-OX40L) factors contribute to NK cell-DC immune orchestration. These interactions may underlie the increased cytokine production and degranulation capacity we observe in BRGSF mice.…”

Section: Discussionmentioning

confidence: 99%

A functional DC cross talk promotes human ILC homeostasis in humanized mice

et al. 2017

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Section: Discussionmentioning

confidence: 99%

A functional DC cross talk promotes human ILC homeostasis in humanized mice

et al. 2017

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“…Abnormal expression and dysfunction of NK cell receptors has been observed under HBV infection (57). Regarding activating receptors, liver biopsies from woodchucks infected with a hepatitis virus showed upregulation of NKp46 (58).…”

mentioning

confidence: 99%

NK Cells Help Induce Anti–Hepatitis B Virus CD8+ T Cell Immunity in Mice

Zheng¹,

Sun

Wei

et al. 2016

The Journal of Immunology

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Although recent clinical studies demonstrate that NK cell function is impaired in hepatitis B virus (HBV)–persistent patients, whether or how NK cells play a role in anti-HBV adaptive immunity remains to be explored. Using a mouse model mimicking acute HBV infection by hydrodynamic injection of an HBV plasmid, we observed that although serum hepatitis B surface Ag and hepatitis B envelope Ag were eliminated within 3 to 4 wk, HBV might persist for >8 wk in CD8−/− mice and that adoptive transfer of anti-HBV CD8+ T cells restored the ability to clear HBV in HBV-carrier Rag1−/− mice. These results indicate that CD8+ T cells are critical in HBV elimination. Furthermore, NK cells increased IFN-γ production after HBV plasmid injection, and NK cell depletion led to significantly increased HBV persistence along with reduced frequency of hepatitis B core Ag–specific CD8+ T cells. Adoptive transfer of IFN-γ–sufficient NK cells restored donor CD8+ T cell function, indicating that NK cells positively regulated CD8+ T cells via secreting IFN-γ. We also observed that NK cell depletion correlated with decreased effector memory CD8+ T cell frequencies. Importantly, adoptive transfer experiments showed that NK cells were involved in anti-HBV CD8+ T cell recall responses. Moreover, DX5+CD49a− conventional, but not DX5−CD49a+ liver-resident, NK cells were involved in improving CD8+ T cell responses against HBV. Overall, the current study reveals that NK cells, especially DX5+CD49a− conventional NK cells, promote the antiviral activity of CD8+ T cell responses via secreting IFN-γ in a mouse model mimicking acute HBV infection.

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“…Shimizu and Fujii demonstrated that bone-marrow-derived DC immunization generated long-term NK-dependent antitumor immunity in a mouse model of melanoma, and that the longlasting antitumor NK response required endogenous DC [39]. Bouwer et al reported also the important contribution of NK cells in B16 melanoma challenge and their helper role in enhancing antitumor immunity [40]. Morandi et al recently demonstrated the in vivo relevance of DC editing by NK cells in expanding cancer-specific cytotoxic T lymphocytes (CTLs) in a TS/A mouse model of mammary adenocarcinoma.…”

Section: Enhancing Nk-dc Crosstalk In Cancer Immunotherapymentioning

confidence: 95%

Bidirectional Interactions of NK Cells and Dendritic Cells in Immunotherapy: Current and Future Perspective

et al. 2015

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NK cells and dendritic cells (DC) are innate cellular components that regulate adaptive immune responses in the immune surveillance of cancer and infections. Interactions of NK and DC are bidirectional. In this mini review, we summarized how NK cells regulate immature DC editing and maturation, how DC regulate NK-cell functions reciprocally in the NK-DC crosstalk, and the importance of NK-DC crosstalk in antitumor immunity. Enhancing NK-DC crosstalk by cellular factor(s), antibodies or creating a microenvironment that promote NK activations, DC maturation and NK-DC crosstalk will provide new insights into future development of DC-based immunotherapy.

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NK Cells Are Required for Dendritic Cell–Based Immunotherapy at the Time of Tumor Challenge

Cited by 48 publications

References 58 publications

A functional DC cross talk promotes human ILC homeostasis in humanized mice

A functional DC cross talk promotes human ILC homeostasis in humanized mice

NK Cells Help Induce Anti–Hepatitis B Virus CD8+ T Cell Immunity in Mice

Bidirectional Interactions of NK Cells and Dendritic Cells in Immunotherapy: Current and Future Perspective

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