2021
DOI: 10.1016/j.canlet.2020.09.021
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NK cells-directed therapies target circulating tumor cells and metastasis

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Cited by 65 publications
(39 citation statements)
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“…However, the responsible biological mechanisms of CTC and T lymphocyte interactions are yet to be fully unraveled. This correlation was also found for NK cells in NSCLC (Ye et al, 2017), which is not surprising considering their cytotoxic effects on CTCs (Dianat-Moghadam et al, 2021).…”
Section: Relationship Between Ctcs and Other Cell Typessupporting
confidence: 73%
“…However, the responsible biological mechanisms of CTC and T lymphocyte interactions are yet to be fully unraveled. This correlation was also found for NK cells in NSCLC (Ye et al, 2017), which is not surprising considering their cytotoxic effects on CTCs (Dianat-Moghadam et al, 2021).…”
Section: Relationship Between Ctcs and Other Cell Typessupporting
confidence: 73%
“…Surgical stress upregulates the concentration of proangiogenic factors, including vascular endothelial growth factor (VEGF), and triggers the release of growth factors that promote local and distant growth of malignant tissue ( 54 , 55 ). Innate immune components such as NK cells play a crucial role in eliminating circulating tumor cells and preventing metastasis ( 56 ), where reduced expression of circulating NK cell phenotypes are associated with tumor progression ( 57 ). Many studies report reduced postoperative NK cell and certain lymphocyte subsets functions, and an inverse correlation of NK cell function with tumor stage and metastatic growth ( 58 , 59 ).…”
Section: Perioperative Factors Associated With Cancer Promotionmentioning
confidence: 99%
“…In breast cancer, a decrease in CD8+ T cells and IFN-γ can lead to an increase in the CTC count [201]. On the other hand, activated NK cells can repress metastasis via CTC killing [202].…”
Section: Effects Of Curcumin and Flavonoids On Tumour-associated And -Infiltrating Cells: Suppression Of Ctc Supportmentioning
confidence: 99%