NKG2C copy number variations in five distinct populations in mainland China and susceptibility to nasopharyngeal carcinoma (NPC)

Li, Lixin; Tian, Wei; Wang, Wen Yi; Liu, Kang Long; Wang, Jun Long; Jin, He; Cai, JinHong; Wang, Jun Jie

doi:10.1016/j.humimm.2015.01.022

Cited by 9 publications

(15 citation statements)

References 33 publications

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“…Subjects. The sample panel consisted of 158 individuals of Mongol ethnicity derived from the original 160 Mongolian samples recruited from Baotou Prefecture, central Inner Mongolia Autonomous Region, northern China [17]. The study group comprised 46.84% men (74/158) and 53.16% women (84/158).…”

Section: Methodsmentioning

confidence: 99%

MICA,MICB Polymorphisms and Linkage Disequilibrium with HLA‐B in a Chinese Mongolian Population

et al. 2016

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In this study, polymorphisms of major histocompatibility complex class I chain-related genes A and B (MICA and MICB) and human leucocyte antigen (HLA)-B gene were investigated for 158 unrelated Chinese Mongolian subjects recruited from central Inner Mongolia Autonomous Region, northern China, by polymerase chain reaction-sequence-based typing (PCR-SBT) and cloning. Collectively, 79 alleles, including 20 MICA, 12 MICB and 47 HLA-B alleles, were identified. MICA*008:01 (21.2%), MICB*005:02 (48.1%) and HLA-B*51:01 (7.91%) were the most common alleles. Significant global linkage disequilibrium (LD) was detected between HLA-B and MICA, HLA-B and MICB, and MICA and MICB loci (all P < 0.000001). The most frequent haplotypes were HLA-B*51:01-MICA*009:01 (7.28%), HLA-B*58:01-MICB*008 (6.96%), MICA*010-MICB*005:02 (13.92%) and HLA-B*58:01-MICA*002:01-MICB*008 (6.96%). HLA-B-MICA haplotypes such as HLA-B*50:01-MICA*009:02 were associated with single MICB allele. Some HLA-B-MICA haplotypes were associated with multiple MICB alleles, including HLA-B*51:01-MICA*009:01. One novel MICB allele, MICB*031, was identified, which has possibly arisen from MICB*002:01 through single mutation event. We also confirmed the existence of a recently recognized MICA allele, MICA*073, whose ethnic origin has not been previously described. Genotype distributions at MICA, MICB and HLA-B were consistent with a neutrality model. Our results provide new insight into MIC genetic polymorphisms in Chinese ethnic groups. Findings shown here are important from an anthropologic perspective and will inform future studies of the potential role of MIC genes in allogeneic organ transplantation and HLAlinked disease association in populations of related ancestry.

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Section: Methodsmentioning

confidence: 99%

MICA,MICB Polymorphisms and Linkage Disequilibrium with HLA‐B in a Chinese Mongolian Population

et al. 2016

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“…Mature DCs were collected and separated into the following 4 groups: (1) NPC patients (mixed cells + FSTL1), (2)…”

Section: Experimental Groupsmentioning

confidence: 99%

“…People between 40 and 50 years of age are at high risk for this type of carcinoma, and the disease is 2 to 3 times more common in men than women. Ninety‐eight percent of NPC originates in the nasopharynx and is characterized as a poorly differentiated squamous cell carcinoma . The etiology of NPC involves genetic factors, infection with the Epstein‐Barr virus (EBV), and environmental factors.…”

Section: Introductionmentioning

confidence: 99%

Follistatin‐like protein 1 contributes to dendritic cell and T‐lymphocyte activation in nasopharyngeal carcinoma patients by altering nuclear factor κb and Jun N‐terminal kinase expression

Wang

Huang

et al. 2016

Cell Biochemistry & Function

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Follistatin‐like protein 1 (FSTL1) is a newly characterized protein that can regulate the immune response in various ways. Dendritic cells (DCs) are central to immune regulation. In this study, we explored the impact of FSTL1 on DC activity in nasopharyngeal carcinoma (NPC) patients. The surface expression of CD40, CD86, and HLA‐DR on DCs was analyzed and showed significantly elevated expression levels, indicating DC maturity. After FSTL1 was added to DCs collected from NPC patients (n = 50), controls (n = 47), and healthy donors (n = 10), interferon γ secretion and T‐cell receptor expression in cytotoxic T lymphocytes were also investigated. In the experimental groups, the expression of the critical immune protein nuclear factor (NF)‐κb was upregulated, whereas Jun N‐terminal kinase (JNK) was downregulated. Our findings demonstrate that FSTL1 plays a critical role in immune regulation, enhancing the antigen presentation ability of DCs by up‐regulating NF‐κb expression and down‐regulating JNK expression.

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“…NPC is the most prevalent head and neck tumor in some parts of Asia and Africa, and EBV exposure is a common factor implicated in NPC etiology . Although people have paid more attention to their health in recent years, most NPC cases are diagnosed at advanced stages due to the poor accessibility of physical examinations and the nonspecific symptoms at the onset of the disease . The high relapse rate limits the therapeutic effect and the five‐year survival rate of NPC patients to low levels .…”

Section: Introductionmentioning

confidence: 99%

“…1 Although people have paid more attention to their health in recent years, most NPC cases are diagnosed at advanced stages due to the poor accessibility of physical examinations and the nonspecific symptoms at the onset of the disease. [6][7][8] The high relapse rate limits the therapeutic effect and the five-year survival rate of NPC patients to low levels. [8][9][10] Clearly, it is indispensable to characterize specific biomarkers for precise early diagnosis in high-risk individuals and for the assessment of treatment effectiveness.…”

Section: Introductionmentioning

confidence: 99%

Differential expression profiling of lncRNAs related to Epstein‐Barr virus infection in the epithelial cells

Zhang

Zuo

et al. 2019

Journal of Medical Virology

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Epstein‐Barr virus (EBV) is a prevalent γ‐herpesvirus associated with a variety of cancers, including epithelial nasopharyngeal carcinoma (NPC) and gastric carcinoma (GC). Long noncoding RNAs (lncRNAs) are emerging as powerful regulators that have demonstrated to play crucial roles in cancer development. In this approach, based on genome‐wide RNA sequencing, we examined the lncRNA expression profiles in four EBV genome‐infected and EBV‐negative 293 cells. A series of lncRNAs were found to be dysregulated in a comparative analysis. Then, eight typical lncRNAs were selected for validation of expression levels by real‐time quantitative polymerase chain reaction and were detected in EBV‐positive or EBV‐negative GC and NPC cells. The differential expression patterns of the eight lncRNAs for validation were fundamentally identical to those revealed in RNA sequencing. Particularly, the differential expression of these lncRNAs in GC and NPC cells indicated their possible roles in EBV infection and tumorigenesis. In addition, a predicted lncRNA‐microRNA‐messenger RNA network suggested their potential interactions. This study reveals the first lncRNAome related to EBV infection in the epithelial cells and provides novel clues for the study of viral role in epithelial cancers through the interaction between EBV and host lncRNAs.

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NKG2C copy number variations in five distinct populations in mainland China and susceptibility to nasopharyngeal carcinoma (NPC)

Cited by 9 publications

References 33 publications

MICA,MICB Polymorphisms and Linkage Disequilibrium with HLA‐B in a Chinese Mongolian Population

MICA,MICB Polymorphisms and Linkage Disequilibrium with HLA‐B in a Chinese Mongolian Population

Follistatin‐like protein 1 contributes to dendritic cell and T‐lymphocyte activation in nasopharyngeal carcinoma patients by altering nuclear factor κb and Jun N‐terminal kinase expression

Differential expression profiling of lncRNAs related to Epstein‐Barr virus infection in the epithelial cells

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