NKT cells: facts, functions and fallacies

Godfrey, Dale I.; Hammond, Kirsten J. L.; Poulton, Lynn D.; Smyth, Mark J.; Baxter, Alan G.

doi:10.1016/s0167-5699(00)01735-7

Cited by 786 publications

(779 citation statements)

References 119 publications

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“…The proposed role of NK/T cells in immune responses ranges from suppression of autoimmunity to tumor rejection. 36,37 While in peripheral blood NK/T cells account for less than 6% of CD3-positive lymphocytes, our study shows that about 16% of the CD3-positive cells present in the spleen express CD16/56 antigen(s). A relatively high frequency of these cells has been also reported in the liver, where up to 55% (mean 27%) of CD3-positive lymphocytes express NK markers.…”

Section: Discussionmentioning

confidence: 58%

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Flow cytometric analysis of normal and reactive spleen

Colovai

Giatzikis

et al. 2004

Modern Pathology

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Spleen is surgically removed for both non-neoplastic and neoplastic pathologies. A significant proportion of splenectomy specimens require distinguishing between reactive and neoplastic conditions (eg lymphoma). To establish a 'normal' reference range for the spleen lymphocyte subsets, fresh samples of benign, reactive spleens obtained from adult patients (N ¼ 12) and samples of normal spleen obtained from cadaveric transplant donors (N ¼ 14) were analyzed using three-and four-color flow cytometry. Study of pan-B, -T, and -NK marker expression revealed that the frequency of T cells is higher and that of B cells is lower in reactive (nonneoplastic) compared to normal (cadaveric) spleen. Furthermore, our study established a frame of reference for cell markers commonly used for immunophenotyping of lymphoma, and identified discrete lymphocyte subsets, such as early plasma cells and T cells carrying the phenotype of the NK/T subset. These results will facilitate an accurate interpretation of the flow cytometric analysis of human spleen lymphocytes.

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Section: Discussionmentioning

confidence: 58%

“…36 This T-cell subset has been intensively studied as a possible bridge between innate and adaptive immunity. The proposed role of NK/T cells in immune responses ranges from suppression of autoimmunity to tumor rejection.…”

Section: Discussionmentioning

confidence: 99%

Flow cytometric analysis of normal and reactive spleen

Colovai

Giatzikis

et al. 2004

Modern Pathology

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“…IL-12, which is produced at sites of inflammation, has been shown to preferentially drive IFNγ production in iNKT cells [90]. However, IL-12 has also been shown to enhance IL-4 production by iNKT cells [91].…”

Section: The Influence Of the Microenvironment On The Inkt Cell Responsementioning

confidence: 99%

CD1d-restricted iNKT cells, the ‘Swiss-Army knife’ of the immune system

Matsuda

Mallevaey

Scott‐Browne

et al. 2008

Current Opinion in Immunology

359

399

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SummaryNatural Killer T cells are a distinct lymphocyte lineage that regulates a broad range of immune responses. NKT cells recognize glycolipids presented by the non-classical MHC molecule CD1d. Structural insight into the TCR/glycolipid/CD1d tri-complex has revealed an unusual and unexpected mode of recognition. Recent studies have also identified some of the signaling events during NKT cell development that give NKT cells their innate phenotype. Pathogen-derived glycolipid antigens continue to be found, and new mechanisms of NKT cell activation have been described. Finally, NKT cells have been shown to be remarkably versatile in function during various immune responses. Whether these extensive functional capacities can be attributed to a single population sensitive to environmental cues or if functionally distinct NKT cell subpopulations exist remains unresolved.

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“…NKT [17] and regulatory T cells [18] have both been shown to regulate T cell proliferation and differentiation. Since the liver is known to be a regulatory environment, we analyzed the percentage of these populations within the corresponding blood and liver lymphocytes.…”

Section: Potential Regulation Of Virus-specific Cd8 + T Cells Within mentioning

confidence: 99%

Virus‐specific CD8⁺ T lymphocytes within the normal human liver

et al. 2004

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The frequency and phenotype of human antiviral memory CD8 + T cells in blood are well studied, yet little is known about their distribution within tissues. Analysis of antiviral CD8 + T cell populations derived from a unique set of normal liver and blood samples identified a consistent population of virus-specific cells within the liver. In comparison to the circulating T cells, the liver-derived T cells were present at frequencies which were variably enriched compared to that in the blood, and showed significant differences with regard to the expression of CD45RA, CD45RO, CD95, CCR7, CD27 and CD28. The differences in these cell surface markers are consistent with a mature 'effector memory' phenotype of antigen-specific CD8 + T cells within the liver. An enrichment of an activated subset of NKT cells (V § 24/V g 11) was also observed, a finding which may be relevant to the regulation of the antiviral populations.

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NKT cells: facts, functions and fallacies

Cited by 786 publications

References 119 publications

Flow cytometric analysis of normal and reactive spleen

Flow cytometric analysis of normal and reactive spleen

CD1d-restricted iNKT cells, the ‘Swiss-Army knife’ of the immune system

Virus‐specific CD8⁺ T lymphocytes within the normal human liver

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NKT cells: facts, functions and fallacies

Cited by 786 publications

References 119 publications

Flow cytometric analysis of normal and reactive spleen

Flow cytometric analysis of normal and reactive spleen

CD1d-restricted iNKT cells, the ‘Swiss-Army knife’ of the immune system

Virus‐specific CD8+ T lymphocytes within the normal human liver

Contact Info

Product

Resources

About

Virus‐specific CD8⁺ T lymphocytes within the normal human liver