NLRP1 in Bone Marrow Microenvironment Controls Hematopoietic Reconstitution After Transplantation

Clodronate liposomes may biases MSC differentiation toward adipogenesis through activation of NLRP3

“…The bone marrow hematopoietic microenvironment is composed of complex cell populations, including osteoblasts, osteoclasts and adipocytes, which all play essential regulatory and supportive roles in bone marrow hematopoiesis; various non-cytokines expressed by these cells, such as OPN, TPO, VEGF, TGF-β, contribute to the hematopoietic regulation of the hematopoietic microenvironment [ 14 ]. In our previous study, we found that various inflammatory complexes such as NLRP1, NLRP3, NLRP6 and NLRC4 were expressed in bone marrow cells after hematopoietic stem cell transplantation and that the expression of Caspase-1, IL-1β and IL-18 was increased, suggesting that NLRP3/Caspase-1 plays an important role in inflammatory bone marrow injury after transplantation [ 15 ].…”