NLRP3 inflammasome upregulates PD-L1 expression and contributes to immune suppression in lymphoma

Prognostic Value of NLRP3 Inflammasome and TLR4 Expression in Breast Cancer Patients

“…Inflammasome components are involved in different physiological and pathological conditions, and their contribution in different cancers has been highlighted in the past few years (9)(10)(11)(12). The role of inflammasomes in cancer is dual.…”

“…This behavior makes inflammasomes the perfect structure bridging chronic inflammation, carcinogenesis and tumor progression. On the other hand, inflammasomes can constrain tumor cell survival by supporting tumor suppressors and immune response and promoting cell death by pyroptosis ( 9 , 15 , 16 ). However, inflammasomes are not the only complex with a dual role and the TME, tissue type and cell type are also involved in determining oncogene and onco-suppressor behavior.…”

Golgi phosphoprotein 3 promotes the proliferation of gallbladder carcinoma cells via regulation of the NLRP3 inflammasome

“…Nucleotide-binding domain leucine-rich repeat (NLR) and pyrin domain containing receptor 3 (NLRP3) comprise the NLRP3 inflammasomes together with apoptosis associated speck like protein and pro-caspase-1 (18,19). Physiological levels of NLRP3 activation protects the body's inflammatory immune system via activation of Caspase-1, whereas uncontrolled activation will lead to dysregulated inflammation, autoimmune diseases, neurodegenerative diseases, and even malignant tumors (20)(21)(22)(23)(24). Recently, a number of studies have reported that the overactivation of NLRP3 is closely associated with the progression of several malignant tumors (24)(25)(26)(27).…”

“…Recently, a number of studies have reported that the overactivation of NLRP3 is closely associated with the progression of several malignant tumors (24)(25)(26)(27). To date, there are numerous studies on the downstream effects of NLRP3 (22)(23)(24)(25). There is evidence that the NLRP3/Caspase-1 pathway can promote the occurrence and progression of adenocarcinoma, and IL-1β, an important member of the NLRP3 Golgi phosphoprotein 3 promotes the proliferation of gallbladder carcinoma cells via regulation of the NLRP3 inflammasome inflammasome, has been found to be closely related with the proliferation of GBC (25,28).…”

The Role of EBV-Encoded LMP1 in the NPC Tumor Microenvironment: From Function to Therapy

“…Induction of IL-6, IL-1b, IL-18 and GM-CSF in the TME subsequently promoted MDSC differentiation and expansion as well as proliferation and apoptotic resistance of EBV-infected NPC cells (67,69,70). Besides, NLRP3 inflammasome and HIF-1a have been found to upregulate PD-L1 expression, in turn blocking effector immune cell proliferation (71,72). Therefore, LMP1-mediated glycolytic activities suppress antitumor immune responses in NPC through multiple pathways.…”