NMDA Receptor-dependent LTD in different subfields of hippocampus in vivo and in vitro

NMDA Receptor as a Newly Identified Member of the Metabotropic Glutamate Receptor Family: Clinical Implications for Neurodegenerative Diseases

“…LFSinduced synaptic depression has been well characterized in acute hippocampal slice preparations and is referred to as NMDAR-dependent LTD (Thiels et al, 1996). Blockade of NMDAR function by using APV [D-(-)-2-amino-5-phosphonopentanoic acid], a widely used antagonist, completely blocked LTD induction in the hippocampus, consistent with previous observations.…”

Frequency-dependent changes in synaptic plasticity and brain-derived neurotrophic factor (BDNF) expression in the CA1 to perirhinal cortex projection

“…This phenomenon has also been described in the literature. The ability of a synapse to be modulated both positively and negatively by different frequencies supports the case for changes in synaptic strength as a candidate for the physiological basis of learning and memory (Bear et al, 1987;Thiels et al, 1996). In particular, this modifiable ability of the synapse supports recent suggestions that memories are dynamic rather than static in nature, they can be updated, erased or impaired by subsequent experiences and therefore, there is a need for synapses to reflect this by also having the ability to change strength, raise or lower synaptic thresholds (Abraham and Williams, 2008) and to shift the synaptic modification range (Rioult-Pedotti et al, 2007) rather than simply being unmodifiable and locked at a certain strength.…”

Mitogen-Activated Protein Kinase-Mediated Reinforcement of Hippocampal Early Long-Term Depression by the Type IV-Specific Phosphodiesterase Inhibitor Rolipram and Its Effect on Synaptic Tagging

“…Zhang et al (2004) have found in behavioral experiments a functional link between MAPK/extracellular regulated kinase (ERK) and cAMP signaling pathways in the mediation of long-term memory, in which PDE4 is likely to be involved. Moreover, ERK activation is necessary to induce the persistent maintenance and expression of NMDA receptor-dependent LTD in area CA1 of the adult hippocampus in vivo (Thiels et al, 1996). Is MAPK activation also essential for RLTD?…”