NMDA Receptor–Dependent Synaptic Potentiation via APPL1 Signaling Is Required for the Accessibility of a Prefrontal Neuronal Assembly in Retrieving Fear Extinction

Hua, Shushan; Ding, Jin-Jun; Sun, Tian-Cheng; Guo, Chunguang; Zhang, Ying; Yu, Zi-Hui; Cao, Yiqing; Zhong, Lin-Hong; Wu, Yu; Guo, Luying; Luo, Jianhong; Cui, Yihui; Qiu, Shuang

doi:10.1016/j.biopsych.2023.02.013

Cited by 7 publications

(3 citation statements)

References 73 publications

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“…Notably, optogenetic induction of LTP in the BLA→mPFC and vHPC→mPFC engram connectivity restores the retrieval of extinction memory when presented with natural cues that would otherwise trigger the spontaneous recovery of extinguished fear [ 16 ]. These findings align with recent research suggesting that NMDAR-dependent synaptic potentiation in mPFC engram neurons [ 95 ] represents mnemonic information associated with extinction.…”

Section: Forgetting Of Extinction Memory: Vulnerable Engram Constructsupporting

confidence: 91%

Memory Trace for Fear Extinction: Fragile yet Reinforceable

Liu,

Ye,

et al. 2023

Neurosci. Bull.

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Fear extinction is a biological process in which learned fear behavior diminishes without anticipated reinforcement, allowing the organism to re-adapt to ever-changing situations. Based on the behavioral hypothesis that extinction is new learning and forms an extinction memory, this new memory is more readily forgettable than the original fear memory. The brain’s cellular and synaptic traces underpinning this inherently fragile yet reinforceable extinction memory remain unclear. Intriguing questions are about the whereabouts of the engram neurons that emerged during extinction learning and how they constitute a dynamically evolving functional construct that works in concert to store and express the extinction memory. In this review, we discuss recent advances in the engram circuits and their neural connectivity plasticity for fear extinction, aiming to establish a conceptual framework for understanding the dynamic competition between fear and extinction memories in adaptive control of conditioned fear responses.

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Section: Forgetting Of Extinction Memory: Vulnerable Engram Constructsupporting

confidence: 91%

Memory Trace for Fear Extinction: Fragile yet Reinforceable

Liu,

Ye,

et al. 2023

Neurosci. Bull.

View full text Add to dashboard Cite

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“…For example, during encoding of a contextual fear memory, input from the hippocampal-entorhinal complex and basolateral amygdala can establish prefrontal engram cells that are initially weakly encoded, but the prefrontal engram cells gain structure and function after consolidation to the extent that activity in these cells is sufficient for remote memory recall in rodents 31 . Importantly, following extinction learning, memory consolidation in ventromedial prefrontal engram cells is also required for successful fear-extinction recall -that is, to suppress fear expression 32 through basolateral amygdala-mediated inhibition of the central nucleus of the amygdala (the main output region that drives the fear response) 33 . Furthermore, human studies have shown that the ventromedial prefrontal cortex is involved in transformation of the source memory trace into an integrated memory schema 34,35 , a process linked with sleep-dependent memory consolidation (further discussed in 'Sleep and emotional memory') 36 .…”

Section: Introductionmentioning

confidence: 99%

Overnight neuronal plasticity and adaptation to emotional distress

Cabrera,

Koymans,

Poe

et al. 2024

Nat. Rev. Neurosci.

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“…However, memories are usually reconsolidated more than once, implying that memory consolidation is not a one-time process and can only occur after stabilizing protein synthesis (Nader et al, 2000 ; Kindt and Soeter, 2013 ). When subjects are re-exposed to the same, single CS or a similar environment, they may undergo the process of extinction and establish new memory traces (Gu et al, 2022 ; Hua et al, 2023 ). On the other hand, fear generalization refers to extending the learned fear experience to other relevant stimuli or contexts (Dunsmoor et al, 2011 ).…”

Section: Introduction Of Fear Memorymentioning

confidence: 99%

Update on neurobiological mechanisms of fear: illuminating the direction of mechanism exploration and treatment development of trauma and fear-related disorders

Liu

Zhi

et al. 2023

Front. Behav. Neurosci.

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Fear refers to an adaptive response in the face of danger, and the formed fear memory acts as a warning when the individual faces a dangerous situation again, which is of great significance to the survival of humans and animals. Excessive fear response caused by abnormal fear memory can lead to neuropsychiatric disorders. Fear memory has been studied for a long time, which is of a certain guiding effect on the treatment of fear-related disorders. With continuous technological innovations, the study of fear has gradually shifted from the level of brain regions to deeper neural (micro) circuits between brain regions and even within single brain regions, as well as molecular mechanisms. This article briefly outlines the basic knowledge of fear memory and reviews the neurobiological mechanisms of fear extinction and relapse, which aims to provide new insights for future basic research on fear emotions and new ideas for treating trauma and fear-related disorders.

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NMDA Receptor–Dependent Synaptic Potentiation via APPL1 Signaling Is Required for the Accessibility of a Prefrontal Neuronal Assembly in Retrieving Fear Extinction

Cited by 7 publications

References 73 publications

Memory Trace for Fear Extinction: Fragile yet Reinforceable

Memory Trace for Fear Extinction: Fragile yet Reinforceable

Overnight neuronal plasticity and adaptation to emotional distress

Update on neurobiological mechanisms of fear: illuminating the direction of mechanism exploration and treatment development of trauma and fear-related disorders

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