NMDA receptor‐gated visual responses in hippocampal CA1 neurons

Liu, Yu-zhang; Wang, Yao; Tang, Wei; Zhu, Jun-yi; Wang, Zhiru

doi:10.1113/jp275094

Cited by 12 publications

(11 citation statements)

References 33 publications

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“…Non-spatial information has been reported to largely ow into the ventral and anterior hippocampus 18 .Visual signals project to the hippocampus from the visual cortex through a multi-synaptic pathway 19,20 . Previous studies found that hippocampal activity could represent visual stimuli 4 , and neurons in the hippocampus and visual cortex showed synchrony in visual stimuli experiments 21 . The transmission pathways between the hippocampus and auditory cortex are complex.…”

Section: Discussionmentioning

confidence: 92%

“…It has been demonstrated to support a "spatial cognitive map", providing an environment-centric spatial memory system 1,2 . Apart from encoding spatial information, previous studies have revealed that the hippocampal neuronal network also encodes non-spatial information such as visual 3,4 , auditory 5,6,7 , olfactory 8,9 , gustatory 10 , and tactile 11,12 . These observations indicate a more abstract and comprehensive hippocampal cognitive map, formally generating a high-dimensional space for both spatial and nonspatial information.…”

Section: Introductionmentioning

confidence: 99%

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Real-time Multimodal Sensory Detection Using Widefield Hippocampal Calcium Imaging

French,

Sun,

et al. 2023

Preprint

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The hippocampus is a complex structure that has a major role in learning and memory. It also integrates information from multisensory modalities, supporting a comprehensive “cognitive map” for both spatial and non-spatial information. Previous studies have been limited to real-time spatial decoding, typically using electrodes. However, decoding hippocampal non-spatial information in real-time has not been previously described. Here, we have constructed a real-time optical decoder driven by calcium activity of large neuronal ensembles to decode spatial, visual, and auditory information effectively. Using advanced machine learning techniques, our rapid end-to-end decoding achieves high accuracy and provides a “cognitive translation” method. This method enables the real-time investigation of hippocampal neural coding and allows for direct neural communication with animals and patients affected by functional impairments. The ability to decode multimodal sensory inputs in real-time thus forms the basis for a novel all-optical brain-computer interface.

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Real-time Multimodal Sensory Detection Using Widefield Hippocampal Calcium Imaging

French,

Sun,

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…It has been demonstrated to support a “cognitive map”, providing an environment-centric spatial memory system (O’keefe and Nadel, 1978; Spiers et al, 2020). Apart from encoding spatial information, previous studies have revealed that the hippocampal neuronal network also encodes non-spatial information such as visual (Acharya et al, 2016; Liu et al, 2018), auditory (Moita et al, 2003; Itskov et al, 2012; Xiao et al, 2018), odour (Komorowski et al, 2009; Taxidis et al,2020), gustatory (Ho et al, 2011), and tactile information (Pereira et al, 2007; Gener et al, 2013). These intriguing observations indicate a more abstract and comprehensive hippocampal cognitive map, generating a high-dimensional space for both spatial and non-spatial information.…”

Section: Introductionmentioning

confidence: 99%

“…It has been demonstrated to support a "cognitive map", providing an environment-centric spatial memory system Spiers et al, 2020). Apart from encoding spatial information, previous studies have revealed that the hippocampal neuronal network also encodes non-spatial information such as visual (Acharya et al, 2016;Liu et al, 2018), auditory Itskov et al, 2012;Xiao et al, 2018), odour Taxidis et al,2020), gustatory (Ho et al, 2011), and tactile information (Pereira et al, 2007;Gener et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Utilising hippocampal neuronal calcium activity in mouse CA1 for a multimodal optical brain-computer interface

Sun

Habibollahi

Yu³

et al. 2022

Preprint

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The hippocampus has been proposed to integrate information from multiple sensory modalities, supporting a comprehensive “cognitive map” for both spatial and non-spatial information. Previous studies have demonstrated decoding of hippocampal spatial information in real time by recording neuronal action potentials with electrodes. However, decoding of hippocampal non-spatial information robustly in real-time has not been previously shown. Here, we utilise the advantages of widefield optical calcium imaging to construct an optical brain-computer interface (BCI) driven by calcium activity of large neuronal ensembles (∼600 neurons) to decode spatial, visual and auditory information effectively in real time. We developed a high speed end-to-end analysis workflow with advanced machine learning techniques for decoding. This methodology achieves high decoding accuracy and provides a “cognitive translation” approach that may be applied to both research and clinical applications to allow direct neural communication with animals and patients with impairment of function.

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“…Meanwhile, the presence of NMDA receptor-mediated responses in hippocampal CA1 neurons, a synaptic mechanism for hippocampal processing that may play important roles in hippocampus-dependent functions such as learning and memory [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

FKN/NR Signaling Pathway Regulates Hippocampal Inflammatory Responses: the Survival of Hippocampal Neurons in Diabetic Rats with Chronic Unpredictable Mild Stress

Liu

Zhao

Liu

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Aim. To investigate the mechanism via which FKN/CX3CR1 signaling abnormalities mediate N-methyl-D-aspartic acid receptor (NMDA) overexcitation-induced hippocampal neuronal injury in diabetic rats complicated with depression (DD). Methods. Sixty rats were randomly divided into 5 groups. The depression-like behaviors of the rats were evaluated by open field test and Morris water maze. The pathological changes of hippocampus in DD rats were observed by HE staining. The blood levels of inflammatory factors (IL-1β, TNF-α, and IL-6) and neurotransmitters (D-serine and glutamic acid) were determined by enzyme-linked immunosorbent assay (ELISA). The expressions of BDNF, A1 receptor (A1R), A2 receptor (A2R), A3 receptor (A3R), calmodulin dependent kinase II (CaMKII), CX3CR1, CX3CL1 (FKN), NR2A, and NR2B proteins were detected by immunohistochemistry and Western-blotting. Results. Compared with the normal control group, blood glucose level increased significantly and body weight decreased in T2DM group and T2DMC group. In addition, the number of spontaneous activities significantly decreased and the capability of learning and memory was attenuated in T2DMC group and Chronic Stress group. The blood levels of IL-1β, TNF-α, IL-6, glutamate (Glu), and D-serine significantly increased in each model group. After intervention with CX3CR1 antibody, the expressions of BDNF, CaMK II, A1R, and A3R increased and those of A2R, CX3CR1, FKN, NR2A, and NR2B decreased. Conclusion. In the diabetic state, the binding of FKN to CX3CR1 increases, which regulates a variety of adenosine receptors. When it exerts its effect on neurons, the overactivation of NR results in neuronal injury and causes depression.

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NMDA receptor‐gated visual responses in hippocampal CA1 neurons

Cited by 12 publications

References 33 publications

Real-time Multimodal Sensory Detection Using Widefield Hippocampal Calcium Imaging

Real-time Multimodal Sensory Detection Using Widefield Hippocampal Calcium Imaging

Utilising hippocampal neuronal calcium activity in mouse CA1 for a multimodal optical brain-computer interface

FKN/NR Signaling Pathway Regulates Hippocampal Inflammatory Responses: the Survival of Hippocampal Neurons in Diabetic Rats with Chronic Unpredictable Mild Stress

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