NMDA receptors are involved in the antidepressant-like effects of capsaicin following amphetamine withdrawal in male mice

Amiri, Shayan; Alijanpour, Sakineh; Tirgar, Fatemeh; Haj‐Mirzaian, Arya; Amini-Khoei, Hossein; Rahimi-Balaei, Maryam; Rastegar, Mojgan; Ghaderi, Milad; Ghazi‐Khansari, Mahmoud; Zarrindast, Mohammad‐Reza

doi:10.1016/j.neuroscience.2016.05.003

Cited by 34 publications

(15 citation statements)

References 60 publications

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“…Activation of TRPV1 by differential ligands or in differential conditions (physiological or pathological) might exert distinct effects on NMDA receptors. This is accordance with the reports that both TRPV1 agonists and antagonists show the antidepressant effects partly through the inhibition of NMDA receptors (Abdelhamid et al, 2014; Amiri et al, 2016; Manna and Umathe, 2012; Sartim et al, 2017). …”

Section: Discussionsupporting

confidence: 93%

“…Herein, we demonstrated a reciprocal regulation of NMDA receptors by TRPV1. This is in accordance with a recent study that showed that down-regulation of NMDA receptor function partially contributed to the antidepressantlike effects of capsaicin intracerebroventricular injection (Amiri et al, 2016). On the contrary, another study indicated that anandamide, an endogenous agonist of TRPV1, potentiated NMDA receptor-mediated current in a TRPV1-dependent manner in hippocampal neurons (K.…”

Section: Discussionsupporting

confidence: 93%

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Capsaicin protects cortical neurons against ischemia/reperfusion injury via down-regulating NMDA receptors

Huang

Cheng

Tan

et al. 2017

Experimental Neurology

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Capsaicin, the ingredient responsible for the pungent taste of hot chili peppers, is widely used in the study and management of pain. Recently, its neuroprotective effect has been described in multiple studies. Herein, we investigated the underlying mechanisms for the neuroprotective effect of capsaicin. Direct injection of capsaicin (1 or 3 nmol) into the peri-infarct area reduced the infarct volume and improved neurological behavioral scoring and motor coordination function in the middle cerebral artery occlusion (MCAO)/reperfusion model in rats. The time window of the protective effect of capsaicin was within 1 h after reperfusion, when excitotoxicity is the main reason of cell death. In cultured cortical neurons, administration of capsaicin attenuated glutamate-induced excitotoxic injury. With respect to the mechanisms of the neuroprotective effect of capsaicin, reduced calcium influx after glutamate stimulation was observed following capsaicin pretreatment in cortical neurons. Trpv1 knockout abolished the inhibitory effect of capsaicin on glutamate-induced calcium influx and subsequent neuronal death. Reduced expression of GluN1 and GluN2B, subunits of NMDA receptor, was examined after capsaicin treatment in cortical neurons. In summary, our studies reveal that the neuroprotective effect of capsaicin in cortical neurons is TRPV1-dependent and down-regulation of the expression and function of NMDA receptors contributes to the protection afforded by capsaicin.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 93%

Capsaicin protects cortical neurons against ischemia/reperfusion injury via down-regulating NMDA receptors

Huang

Cheng

Tan

et al. 2017

Experimental Neurology

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“…Mice were individually forced to swim in a cylindrical glass tank (diameter: 10 cm, height: 25 cm) containing 19 cm of water (23 ± 1 C) and passive behaviour (immobility time) was measured for 6 min and animal behaviour was recorded at last 4 min of test. Immobility was defined as a period during which the animal floated in the water, making only those movements necessary to keep its head above the water (Amiri et al 2016).…”

Section: Forced Swimming Test (Fst)mentioning

confidence: 99%

Progesterone exerts antidepressant-like effect in a mouse model of maternal separation stress through mitigation of neuroinflammatory response and oxidative stress

Nouri

Hashemzadeh

Soltani

et al. 2019

Pharmaceutical Biology

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Context: Experiencing early-life adversity plays a key role in the development of mood disorders in adulthood. Experiencing adversities during early life period negatively affects brain development. Sex steroids such as progesterone affect the brain structure and functions and subsequently affects behaviour. Objective: We assess the antidepressant-like effect of progesterone in a mouse model of maternal separation (MS) stress, focussing on its anti-neuroinflammatory and antioxidative effects. Materials and methods: NMRI mice were treated with progesterone (10, 50, and 100 mg/kg, i.p., respectively) for 14 days. Valid behavioural tests including forced swimming test (FST), splash test and open field test (OFT) were used. Quantitative reverse transcription-PCR (qRT-PCR) was used for evaluation of genetic expression in the hippocampus. Antioxidant capacity was assessed by the FRAP method and the level of malondialdehide by TBA. Results: MS provoked depressive-like behaviour in mice. Treatment of MS mice with progesterone increased the grooming activity time in the splash test and decreased the immobility time in the FST. In addition, progesterone decreased the expression of inflammatory genes related to neuroinflammation (IL-1b, TNF-a, TLR4 and NLRP3) as well as increased the antioxidant capacity and decreased the lipid peroxidation (MDA) in the hippocampus. Discussion and Conclusion: Administration of progesterone significantly mitigated the negative effects of MS on behaviours relevant to depressive-like behaviour as well as attenuated neuro-immune response and oxidative stress in the hippocampus of MS mice. In this context, we conclude that progesterone, at least partially, via attenuation of oxidative stress and neuroinflammation, exerts antidepressant-like effects.

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“…Amphetamines are one of the most powerful and addictive psychostimulant drugs in many countries and modern societies 1-3. One of the well-known forms of amphetamines, i.e.…”

Section: Introductionmentioning

confidence: 99%

Effects of treatment with estrogen and progesterone on the methamphetamine-induced cognitive impairment in ovariectomized rats

Ghazvini

Khaksari

Esmaeilpour

et al. 2016

Neuroscience Letters

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NMDA receptors are involved in the antidepressant-like effects of capsaicin following amphetamine withdrawal in male mice

Cited by 34 publications

References 60 publications

Capsaicin protects cortical neurons against ischemia/reperfusion injury via down-regulating NMDA receptors

Capsaicin protects cortical neurons against ischemia/reperfusion injury via down-regulating NMDA receptors

Progesterone exerts antidepressant-like effect in a mouse model of maternal separation stress through mitigation of neuroinflammatory response and oxidative stress

Effects of treatment with estrogen and progesterone on the methamphetamine-induced cognitive impairment in ovariectomized rats

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