NMR-based metabolic profiling and in vitro antioxidant and hepatotoxic assessment of partially purified fractions from Golden germander (Teucrium polium L.) methanolic extract

Pacifico, Severina; D’Abrosca, Brigida; Scognamiglio, Monica; D’Angelo, Grazia; Gallicchio, Marialuisa; Galasso, Silvia; Monaco, Pietro; Fiorentino, Antonio

doi:10.1016/j.foodchem.2012.06.071

Cited by 25 publications

(25 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Table 5 summarizes some important bioactive molecules isolated from the Teucrium species, mainly T. polium , using various identification techniques and different extraction procedures [ 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ].…”

Section: Discussionmentioning

confidence: 99%

“…Different techniques were used to identify the bioactive compounds in T. polium aerial parts extracts, using different solvents (water, methanol, 65.5% menthol–water, dichloromethane/methanol, acetone, ethanol 70%, and ethanol 95%) from different regions around the world [ 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ]. A literature review of the phytochemical compounds isolated from T. polium aerial parts showed the identification of more than 130 molecules dominated by terpenoids (60%) [ 45 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Phytochemical Screening, Antibacterial, Antifungal, Antiviral, Cytotoxic, and Anti-Quorum-Sensing Properties of Teucrium polium L. Aerial Parts Methanolic Extract

Alreshidi

Noumi

Bouslama

et al. 2020

Plants

View full text Add to dashboard Cite

The chemical profile of Teucrium polium L. (T. polium) methanolic extract was tested using liquid chromatography coupled with high resolution mass spectrometry (HR-LCMS). Disc diffusion and microdilution assays were used for the antimicrobial activities. Coxsackievirus B-3 (CVB3) and Herpes simplex virus type 2 (HSV-2) were used for the antiviral activities. Chromobacterium violaceum (ATCC 12472 and CV026) and Pseudomonas aeruginosa PAO1 were used as starter strains for the anti-quorum sensing tests. Isoprenoids are the main class of compounds identified, and 13R-hydroxy-9E,11Z-octadecadienoic acid, valtratum, rhoifolin, sericetin diacetate, and dihydrosamidin were the dominant phytoconstituents. The highest mean diameter of growth inhibition zone was recorded for Acinetobacter baumannii (19.33 ± 1.15 mm). The minimal inhibitory concentrations were ranging from 6.25 to 25 mg/mL for bacterial strains, and from 6.25 to 25 mg/mL for Candida species. The 50% cytotoxic concentration on VERO (African Green Monkey Kidney) cell lines was estimated at 209 µg/mL. No antiviral activity was recorded. Additionally, T. polium extract was able to inhibit P. aeruginosa PAO1 motility in a concentration-dependent manner. However, the tested extract was able to inhibit 23.66% of the swarming and 35.25% of swimming capacities of PAO1 at 100 µg/mL. These results highlighted the role of germander as a potent antimicrobial agent that can interfere with the virulence factors controlled by the quorum-sensing systems.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Phytochemical Screening, Antibacterial, Antifungal, Antiviral, Cytotoxic, and Anti-Quorum-Sensing Properties of Teucrium polium L. Aerial Parts Methanolic Extract

Alreshidi

Noumi

Bouslama

et al. 2020

Plants

View full text Add to dashboard Cite

show abstract

“…Finally, Foeniculum vulgare was characterized by chlorogenic acids and flavonoids, identified, based on 1 H-NMR data as kaempferol and quercetin [ 17 ]. Chlorogenic acid was reported for the first time from this species, to the best of our knowledge.…”

Section: Resultsmentioning

confidence: 99%

“…In this framework, it is worth to underlining that first of all the health promoting capacity of bioactive compounds could be dependent on synergisms. Secondly, these plants could also contain potential toxic compounds, as reported for several Lamiaceae [ 17 ]. Nevertheless, the role in nutrition of primary metabolites is often disregarded [ 18 ].…”

Section: Resultsmentioning

confidence: 99%

Chemical Composition and Seasonality of Aromatic Mediterranean Plant Species by NMR-Based Metabolomics

Scognamiglio

D’Abrosca

Esposito

et al. 2015

Journal of Analytical Methods in Chemistry

Self Cite

View full text Add to dashboard Cite

An NMR-based metabolomic approach has been applied to analyse seven aromatic Mediterranean plant species used in traditional cuisine. Based on the ethnobotanical use of these plants, the approach has been employed in order to study the metabolic changes during different seasons. Primary and secondary metabolites have been detected and quantified. Flavonoids (apigenin, quercetin, and kaempferol derivatives) and phenylpropanoid derivatives (e.g., chlorogenic and rosmarinic acid) are the main identified polyphenols. The richness in these metabolites could explain the biological properties ascribed to these plant species.

show abstract

“…[70] Golden germander (Teucrium polium L.) is a Mediterranean shrub of the Labiatae family, shows antidiabetic effects. [71] Ageratum conyzoides and Commelina africana showed hypoglycemic effect. [72] Aerial parts of Phlomis anisodonta ME (PAE) showed a significant reduction in FBG in STZ-induced diabetic rats.…”

Section: Aegle Marmelosmentioning

confidence: 99%

Untitled

2016

IJGP

View full text Add to dashboard Cite

The present review explains the use of natural plant products for therapeutics of diabetes. It is a serious metabolic disorder that imposes multiple effects on human health. Although diabetes is curable, an erratic lifestyle always make panic and causes disease severity if proper medication is not being made available. Several ethnomedicines have been used by local people in form of crude extracts prepared from flowers, fruits, and roots of endemic plant species for cure of diabetes. There is a common usage of herbal parts for preparation of concoctions, syrups, vegetables, juices, green tea, from leaves, and roots for therapeutic purposes. This article explains antidiabetic effects of various plant secondary metabolites such as anthraquinones, flavonoids, secoiridoids, iridoids, flavanones, biophenols, triterpenes, benzoic acid derivatives, isochromans, and phytosterols. Daily meals containing good nutraceuticals such as protein and fiber can replace carbohydrate food that is a main source of glucose. Mainly, herbal foods rich in flavanols and polyphenols show hypoglycemic effects and can be used in the prevention of diabetes-induced vascular dysfunctions. Antidiabetic plant natural products restore insulin level and increase utilization of external glucose. Herbal dietary supplementation having diverse antioxidants, fibers, minerals, and antiglycants show inhibitory activity against α-amylase and α-glycosidase can easily control carbohydrate metabolism in humans. No doubt plant origin natural products can be used as alternative medicine for treatment of diabetes, but they must need proper composition and formulation before being used.

show abstract

NMR-based metabolic profiling and in vitro antioxidant and hepatotoxic assessment of partially purified fractions from Golden germander (Teucrium polium L.) methanolic extract

Cited by 25 publications

References 29 publications

Phytochemical Screening, Antibacterial, Antifungal, Antiviral, Cytotoxic, and Anti-Quorum-Sensing Properties of Teucrium polium L. Aerial Parts Methanolic Extract

Phytochemical Screening, Antibacterial, Antifungal, Antiviral, Cytotoxic, and Anti-Quorum-Sensing Properties of Teucrium polium L. Aerial Parts Methanolic Extract

Chemical Composition and Seasonality of Aromatic Mediterranean Plant Species by NMR-Based Metabolomics

Untitled

Contact Info

Product

Resources

About