NMR‐based metabolomics and bioassays to study phytotoxic extracts and putative phytotoxins from Mediterranean plant species

Scognamiglio, Monica; Graziani, Vittoria; Tsafantakis, Nikolaos; Esposito, Assunta; Fiorentino, Antonio; D’Abrosca, Brigida

doi:10.1002/pca.2842

Cited by 6 publications

(5 citation statements)

References 28 publications

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“…Mediterranean ecosystems show a great diversity of plant species derived from the specific climatic conditions and the heterogeneity of their habitats [72]. The species that dominate these habitats endure harsh conditions due to the frequency of wild fires, high temperatures, water stress in summer and herbivory [73]. These unfavorable conditions stimulate the production of compounds derived from secondary metabolism, specifically phenolic compounds [74,75], which play an important ecological role in the adaptive response to these unfavorable conditions.…”

Section: Phenolic Compounds: Their Importance and Implication In Neur...mentioning

confidence: 99%

Mediterranean Shrub Species as a Source of Biomolecules against Neurodegenerative Diseases

Chaves,

Nogales,

Montero-Fernández

et al. 2023

Molecules

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Neurodegenerative diseases are associated with oxidative stress, due to an imbalance in the oxidation-reduction reactions at the cellular level. Various treatments are available to treat these diseases, although they often do not cure them and have many adverse effects. Therefore, it is necessary to find complementary and/or alternative drugs that replace current treatments with fewer side effects. It has been demonstrated that natural products derived from plants, specifically phenolic compounds, have a great capacity to suppress oxidative stress and neutralize free radicals thus, they may be used as alternative alternative pharmacological treatments for pathological conditions associated with an increase in oxidative stress. The plant species that dominate the Mediterranean ecosystems are characterized by having a wide variety of phenolic compound content. Therefore, these species might be important sources of neuroprotective biomolecules. To evaluate this potential, 24 typical plant species of the Mediterranean ecosystems were selected, identifying the most important compounds present in them. This set of plant species provides a total of 403 different compounds. Of these compounds, 35.7% are phenolic acids and 55.6% are flavonoids. The most relevant of these compounds are gallic, vanillic, caffeic, chlorogenic, p-coumaric, and ferulic acids, apigenin, kaempferol, myricitrin, quercetin, isoquercetin, quercetrin, rutin, catechin and epicatechin, which are widely distributed among the analyzed plant species (in over 10 species) and which have been involved in the literature in the prevention of different neurodegenerative pathologies. It is also important to mention that three of these plant species, Pistacea lentiscus, Lavandula stoechas and Thymus vulgaris, have most of the described compounds with protective properties against neurodegenerative diseases. The present work shows that the plant species that dominate the studied geographic area can provide an important source of phenolic compounds for the pharmacological and biotechnological industry to prepare extracts or isolated compounds for therapy against neurodegenerative diseases.

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Section: Phenolic Compounds: Their Importance and Implication In Neur...mentioning

confidence: 99%

Mediterranean Shrub Species as a Source of Biomolecules against Neurodegenerative Diseases

Chaves,

Nogales,

Montero-Fernández

et al. 2023

Molecules

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“…A promising alternative to traditional methods involves the utilization of plant extracts, offering several advantages, including biodegradability, diverse biological activities, complex chemical diversity, and varied mechanisms of action. This minimizes the likelihood of pathogens developing resistance [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Phytoconstituents and Ergosterol Biosynthesis-Targeting Antimicrobial Activity of Nutmeg (Myristica fragans Houtt.) against Phytopathogens

Cruz,

Sánchez-Hernández,

Teixeira

et al. 2024

Molecules

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In recent years, nutmeg (Myristica fragans Houtt.) has attracted considerable attention in the field of phytochemistry due to its diverse array of bioactive compounds. However, the potential application of nutmeg as a biorational for crop protection has been insufficiently explored. This study investigated the constituents of a nutmeg hydroethanolic extract via gas chromatography-mass spectrometry and vibrational spectroscopy. The research explored the extract’s activity against phytopathogenic fungi and oomycetes, elucidating its mechanism of action. The phytochemical profile revealed fatty acids (including tetradecanoic acid, 9-octadecenoic acid, n-hexadecanoic acid, dodecanoic acid, and octadecanoic acid), methoxyeugenol, and elemicin as the main constituents. Previously unreported phytochemicals included veratone, gelsevirine, and montanine. Significant radial growth inhibition of mycelia was observed against Botrytis cinerea, Colletotrichum acutatum, Diplodia corticola, Phytophthora cinnamomi, and especially against Fusarium culmorum. Mode of action investigation, involving Saccharomyces cerevisiae labeled positively with propidium iodide, and a mutant strain affected in ERG6, encoding sterol C-24 methyltransferase, suggested that the extract induces a necrotic type of death and targets ergosterol biosynthesis. The evidence presented underscores the potential of nutmeg as a source of new antimicrobial agents, showing particular promise against F. culmorum.

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“…Allelopathy is defined as a process of plant–plant chemical interaction with either positive or negative effects [ 13 ]; it is not an isolated event in nature and allelopathy can be regarded as a natural strategy protecting plants against environmental ‘‘enemies’’ and competing plants [ 14 ]. It is known that stress factors stimulate the production of allelochemicals [ 15 , 16 ], and thus the typical species of Mediterranean ecosystems show an abundant production of these compounds [ 17 , 18 , 19 ], which are responsible for the allelopathic activity attributed to many of the species of these ecosystems [ 20 , 21 , 22 , 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

“…In ecosystems such as the Mediterranean, with an abundance of species classified as allelopathic [ 20 , 21 , 22 , 23 , 24 , 25 ], the native plants may also interact with other plants through allelopathy. To confirm the importance of allelopathic potential as a mechanism of invasion of non-native species in these ecosystems, it would be advisable to compare the allelopathic effects of non-native plants with native plants on the same target species and thus avoid overestimating the role of phytotoxicity in the invasion process [ 41 ].…”

Section: Introductionmentioning

confidence: 99%

Comparison of the Allelopathic Potential of Non-Native and Native Species of Mediterranean Ecosystems

Chaves

Felix

Gallego

2023

Plants

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Allelopathy is a frequent interaction between species in Mediterranean ecosystems and it is also one of the proposed strategies to explain the colonisation of invasive species. To confirm the importance of allelopathic potential as a mechanism of invasion of non-native species in Mediterranean ecosystems, it would be advisable to compare the allelopathic effects of non-native plants with native plants on the same target species and thus avoid overestimating the role of phytotoxicity in the invasion process. The main objective of this work was to compare the allelopathic activity of native species typical of Mediterranean ecosystems, classified as allelopathic, with the allelopathic activity of non-native species that may have an invasive character in these ecosystems. To this end, we selected three native species (Cistus ladanifer, Pistacia lentiscus, and Pistacia terebithus) and three non-native species (Acacia dealbata, Acer negundo, and Salix babylonica), and we analysed their effect on the species Lactuca sativa and the native species Lavandula stoechas and Echium plantagineum. The tests on L. sativa showed that all species have allelopathic activity. The tests on L. stoechas and E. plantagineum revealed that P. terebinthus exerted the greatest effect, being the only species that maintained an inhibitory effect at extract concentrations of 50% and 25% in all the analysed parameters, except in germination and cotyledon emergence for E. plantagineum. There were no significant differences in the effect on germination between non-native and native species, although significant differences were found in the effect on root size in the three analysed concentrations, with the native species producing greater inhibition. In conclusion, these species exert a negative effect on the selected native target species, but the negative effect of the native species is greater than that of the non-native species. These results indicate that it is important to compare the allelopathic effects of invasive and native species to correctly estimate the phytotoxic effect of invasive species on their invasiveness

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NMR‐based metabolomics and bioassays to study phytotoxic extracts and putative phytotoxins from Mediterranean plant species

Cited by 6 publications

References 28 publications

Mediterranean Shrub Species as a Source of Biomolecules against Neurodegenerative Diseases

Mediterranean Shrub Species as a Source of Biomolecules against Neurodegenerative Diseases

Phytoconstituents and Ergosterol Biosynthesis-Targeting Antimicrobial Activity of Nutmeg (Myristica fragans Houtt.) against Phytopathogens

Comparison of the Allelopathic Potential of Non-Native and Native Species of Mediterranean Ecosystems

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