NMR-based quantification of rosmarinic and carnosic acids, GC–MS profile and bioactivity relevant to neurodegenerative disorders of Rosmarinus officinalis L. extracts

Jemia, Mariem Ben; Tundis, Rosa; Maggio, Antonella; Rosselli, Sergio; Senatore, Felice; Menichini, Francesco; Bruno, Maurizio; Kchouk, Mohamed Elyes; Loizzo, Monica Rosa

doi:10.1016/j.jff.2013.09.008

Cited by 27 publications

(21 citation statements)

References 36 publications

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“…These studies have shown that substances such as rosemary extract (Ben Jemia et al, 2013), anthocyanin-rich foods (Mitchell Seymour et al, 2014) and polyunsaturated fatty acids (Komprda, 2012) can serve as nutraceuticals, which protect tissues from inflammation and oxidative stress. Recently, pediatricians have also highlighted the role of long-chain polyunsaturated fatty acids (LC-PUFA), in brain development and function.…”

Section: Discussionmentioning

confidence: 99%

Diet supplemented with pancreatic-like enzymes of microbial origin restores the hippocampal neuronal plasticity and behaviour in young pigs with experimental exocrine pancreatic insufficiency

Goncharova

Ушакова

Kovalenko

et al. 2015

Journal of Functional Foods

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Section: Discussionmentioning

confidence: 99%

Diet supplemented with pancreatic-like enzymes of microbial origin restores the hippocampal neuronal plasticity and behaviour in young pigs with experimental exocrine pancreatic insufficiency

Goncharova

Ушакова

Kovalenko

et al. 2015

Journal of Functional Foods

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“…Other authors (VICENTE et al, 2013;JEMIA et al, 2013) also identified 1,8 cineole, camphor, borneol and linalool, amongst others, as the main compounds in the rosemary extract.…”

Section: Gas Chromatography/mass Spectrometry (Gc-ms) Profilementioning

confidence: 91%

Antioxidant and antimicrobial properties of ethanolic extracts of guarana, boldo, rosemary and cinnamon

Bonilla

Sobral

2017

Braz. J. Food Technol.

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In this investigation, the ethanolic extracts of two less known plants, little reported in the literature (guarana and boldo leaves) were studied in comparison with the ethanolic extracts of two well studied plants (cinnamon and rosemary), regarding their colour, GC-MS profile, phenolic content and their antioxidant and antimicrobial properties. The rosemary (59.20 ± 0.28) and guarana (56.63 ± 0.54) extracts showed the highest values for luminosity (L*) and the UV-Vis absorption increased when L* decreased. GC-MS identified a limited number of compounds in the cinnamon and guarana extracts. The cinnamon extract showed the highest value for the total phenolic content (172 mg GA/g extract) as compared to the other extracts. The highest antioxidant capacity was observed for the boldo leaves extract in the TEAC (6.66 ± 0.17 mM) assay and for the rosemary extract in the DPPH (0.80 ± 0.14 mg/L) test. In addition, all the extracts showed antimicrobial activity against the S. aureus strain, indicating that all the extracts studied could be used by food industries to develop new active food packaging materials.Keywords: Herbs; Seeds; Phenols; Volatile compounds; S. aureus; E. coli. ResumoNesta investigação, foram estudados dois extratos etanólicos de plantas pouco conhecidas na literatura (guaraná e boldo-do-chile), em comparação com os extratos etanólicos de duas plantas bastante estudadas (canela e alecrim), quanto aos parâmetros de cor, perfil GC-MS, teor fenólico e propriedades antioxidantes e antimicrobianas. Os extratos de alecrim (59,20 ± 0,28) e guaraná (56,63 ± 0,54) mostraram os maiores valores de luminosidade (L*). A absorção de radiação ultravioleta visível (UV-Vis) aumentou de intensidade quando o valor L* diminuiu. Na análise do perfil GC-MS, identificou-se um número limitado de compostos nos extratos de canela e guaraná. O extrato de canela apresentou o maior conteúdo de compostos fenólicos totais (172 mg GA/g extrato), em comparação com outros extratos. A maior capacidade antioxidante foi observada para o extrato de boldo-do-chile, no ensaio TEAC (6,66 ± 0,17 mM), e para o extrato de alecrim, no teste de DPPH (0,80 ± 0,14 mg/L). Adicionalmente, todos os extratos mostraram atividade antimicrobiana contra a cepa S. aureus, indicando que todos os extratos estudados podem ser utilizados pelas indústrias de alimentos para desenvolver novos materiais ativos de embalagem de alimentos. Palavras

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“…This Mediterranean species belongs to the Lamiaceae family and has traditionally been used as a food ingredient to increase food flavor. However, this plant has also been described as an attractive source of phenolic compounds with important bioactivities (Ben Jemia et al, 2013;Borrás Linares et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Two-step sequential supercritical fluid extracts from rosemary with enhanced anti-proliferative activity

Sánchez‐Camargo

Valdés

Sullini

et al. 2014

Journal of Functional Foods

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Available online A B S T R A C TPreviously, carnosic acid and carnosol have demonstrated anti-proliferative activity against different types of cancer. To obtain extracts enriched in these two key phenolic compounds, two different processes have been developed in the present work based on the use of two-step sequential supercritical fluid extraction (SFE). By removing the interfering, less active fractions in a first step (150 or 300 bar, 40°C, neat CO2, 60 min), suitable enrichment is achieved in the second step (150 bar, 40°C, CO2 + 7% ethanol, 120 min), and this leads to carnosic acid concentrations in the extract as high as 40% of total dry weight, which are among the highest concentrations that have been described with this type of process. The enriched extracts were tested against the HT-29 human adenocarcinoma cell line, showing enhancement of their antiproliferative activity by approximately 3-fold compared to previously reported SFE rosemary extracts and higher inhibitory effects at lower concentrations (30 µg mL −1 of extract). Thus, the proposed two-step SFE process effectively improves the carnosic acid and carnosol recovery in shorter processing times (180 min vs. 300 min). Moreover, the obtained extracts possess higher anti-proliferative activity and consume less solvent.

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NMR-based quantification of rosmarinic and carnosic acids, GC–MS profile and bioactivity relevant to neurodegenerative disorders of Rosmarinus officinalis L. extracts

Cited by 27 publications

References 36 publications

Diet supplemented with pancreatic-like enzymes of microbial origin restores the hippocampal neuronal plasticity and behaviour in young pigs with experimental exocrine pancreatic insufficiency

Diet supplemented with pancreatic-like enzymes of microbial origin restores the hippocampal neuronal plasticity and behaviour in young pigs with experimental exocrine pancreatic insufficiency

Antioxidant and antimicrobial properties of ethanolic extracts of guarana, boldo, rosemary and cinnamon

Two-step sequential supercritical fluid extracts from rosemary with enhanced anti-proliferative activity

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