NMR intrascopy — A new method for studying diffusion in polymers

A novel method for the determination of diffusion coefficients in amorphous poly(3-hydroxybutyrate)

“…If we consider this application, the kinetics of drug release must be determined, but quantitative description requires the knowledge of the diffusion coefficient. This characteristic might be measured and/or calculated by a number of approaches already published in the literature [24][25][26][27][28][29][30][31][32][33][34][35][36][37].…”

“…Recently more advanced quantitative and/or qualitative measurement techniques are used to overcome the deficiencies of sorption and permeation methods [35][36][37]. Yang et al [35] followed the diffusion of water molecules into a PHB-HV polymer phase by FTIR spectroscopy on films immersed into water.…”

“…The main drawback of the approach is that the permeant must be a liquid in order to be able to submerge the polymer into it. The method developed by Kosenko [37] to study molecular diffusion in polymers is based on NMR measurements [37]. He discusses diffusion by the interpretation of time dependent NMR spectra, but does not calculate the actual values of the diffusion coefficient.…”