NMR, surface tension and conductivity studies to determine the inclusion mechanism: thermodynamics of host–guest inclusion complexes of natural amino acids in aqueous cyclodextrins

Abstract

The novel study explains the formation of 1 : 1 host–guest inclusion complexes based upon hydrophobic effects, H-bonds, electrostatic forces and structural effects.

Inclusion complexes of norepinephrine with β-cyclodextrin, 18-crown-6 and cucurbit[7]uril: experimental and molecular dynamics study

“…Host-guest complexation is usually investigated by a portfolio of analytical techniques, such as Fourier transform infrared and Raman spectroscopies, NMR spectroscopy, X-ray crystallography, mass spectrometry, UV-visible and uorescence spectrophotometry and electrochemical techniques. 6,[25][26][27][28][29][30] Furthermore, theoretical molecular modeling calculations, such as density functional theory calculations and molecular dynamics are usually used to shed the light on the molecular recognition mechanism and to delineate the structure of these complexes. 23,[31][32][33][34][35][36] Norepinephrine, NP, is a member of the catecholamine family of compounds known to possess pharmacological activities as neurotransmitters and hormones.…”

Sustenance of Inclusion Complexes of Ionic Liquid with Cyclic Oligosaccharide Molecules in Liquid and Solid Phases by Diverse Approaches

“…The tabulated results and Figure S2 (See supporting information Figure S2), reveal a decreasing trend of conductance values which may be due to the larger size and hence lower mobility of the inclusion complex formed ,. At a concentration near 5 mM of CDs in both the complexes single breaks (See supporting information TablesS7) were originated which is reflected in the conductivity plot, indicates the formation of 1: inclusion complexes ,…”

Synthesis and Characterization of Host Guest Inclusion Complexes of Cyclodextrin Molecules with Theophylline by Diverse Methodologies

“…The solution conductivity of THP is noticeably changed by the addition of ∝-CYD & HP-β-CYD (CYDs). Conductivity (κ) measurement is an important contrivance to illuminate the inclusion incident in solution phase [19][20][21].…”