No association between AICDA 7888 C/T polymorphism, Helicobacter pylori seropositivity, and the risk of atrophic gastritis and gastric cancer in Japanese

Hishida, Asahi; Matsuo, Keitaro; Goto, Yasuyuki; Mitsuda, Yoko; Hiraki, Akio; Naito, Mariko; Wakai, Kenji; Tajima, Kazuo; Hamajima, Nobuyuki

doi:10.1007/s10120-009-0534-7

Cited by 3 publications

(2 citation statements)

References 41 publications

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“…Among the participants who visited Aichi Cancer Center Hospital from the years 2001 to 2005, 583 patients diagnosed with gastric cancer (cases) and 1636 age-and sex-frequency-matched cancer-free outpatients (controls) were recruited. This gastric cancer case-control dataset is the same as the one previously described [14,15]. Informed consent was obtained from all the subjects and the study protocol was approved by the Ethics Committees of Aichi Cancer Center and Nagoya University Graduate School of Medicine.…”

Section: Subjectsmentioning

confidence: 99%

No associations of Toll-like receptor 2 (TLR2) -196 to -174del polymorphism with the risk of Helicobacter pylori seropositivity, gastric atrophy, and gastric cancer in Japanese

et al. 2010

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Asian countries, and is the second greatest cause of cancer deaths in the world [1,2]. A number of studies have established that Helicobacter pylori infection is a feasible risk factor for gastric cancer through the development of gastric atrophy or subsequent precancerous lesions [3,4]. Severe gastric atrophy and corpuspredominant gastritis, as well as intestinal metaplasia, are generally recognized as predominant predispositions to gastric cancer [5]. Host proinfl ammatory genetic factors, in combination with bacterial virulence factors such as CagA, have been shown to determine the severity of gastric damage and the subsequent clinical outcome of H. pylori infection [6,7].Toll-like receptors (TLRs) are type-I transmembrane proteins with extracellular leucine-rich repeat (LRR) motifs and an intracellular Toll/interleukin-1 receptor (TIR) domain [8]. Toll, the founding member of the TLR family, was initially implicated in the establishment of dorsal-ventral patterning in the early development of the Drosophila embryo. Mammalian TLRs have essential roles in the direct recognition of infectious agents, leading to the activation of both innate and adaptive immune responses via nuclear factor-kappa B (NF-κB) signaling pathways. Ten different human TLRs have been identifi ed [9]. Each TLR recognizes specifi c pathogen-associated molecular patterns (PAMPs), including the recognition of lipoproteins, lipoteichoic acid, and zymosan by TLR2; double-stranded for del/del, and 1.14 (95% CI: 0.89-1.45) for ins/del + del/del, relative to the ins/ins genotype compared with gastric atrophy controls; none of these fi ndings were statistically signifi cant. The TLR2 -196 to 174del polymorphism was not signifi cantly associated with either H. pylori seropositivity or gastric atrophy. Conclusion. Our study did not reproduce the association between gastric cancer risk and the TLR2 -196 to -174del polymorphism in Japanese. Further examinations with suffi cient numbers of study subjects are required to verify our fi ndings.

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Section: Subjectsmentioning

confidence: 99%

No associations of Toll-like receptor 2 (TLR2) -196 to -174del polymorphism with the risk of Helicobacter pylori seropositivity, gastric atrophy, and gastric cancer in Japanese

et al. 2010

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“…Ethnic variation in the frequency of genetic polymorphisms may also explain the considerable difference in H. pylori prevalence between ethnic Indians (50-60%), ethnic Chinese (35-55%) and ethnic Malays (10-25%), 6 as yet few studies have investigated whether any such associations exist. 7 H. pylori infection initiates an early innate immune response, which is quickly replaced by a vigorous adaptive response which is unable to eliminate H. pylori infection. 8 The human genetic factors driving the ineffective response to H. pylori infection and carcinogenesis are mostly unknown, although a variety of interconnected pathways have been implicated.…”

Section: Introductionmentioning

confidence: 99%

Variation in human genetic polymorphisms, their association with Helicobacter pylori acquisition and gastric cancer in a multi‐ethnic country

Schmidt

Taylor

et al. 2011

J of Gastro and Hepatol

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Bioinformatics Analysis of Some Genomic Regions in Sheep Population Based on Meta-Analysis

Bayeriyar

Hafezian²,

Farahani³

et al. 2021

rap

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No association between AICDA 7888 C/T polymorphism, Helicobacter pylori seropositivity, and the risk of atrophic gastritis and gastric cancer in Japanese

Cited by 3 publications

References 41 publications

No associations of Toll-like receptor 2 (TLR2) -196 to -174del polymorphism with the risk of Helicobacter pylori seropositivity, gastric atrophy, and gastric cancer in Japanese

No associations of Toll-like receptor 2 (TLR2) -196 to -174del polymorphism with the risk of Helicobacter pylori seropositivity, gastric atrophy, and gastric cancer in Japanese

Variation in human genetic polymorphisms, their association with Helicobacter pylori acquisition and gastric cancer in a multi‐ethnic country

Bioinformatics Analysis of Some Genomic Regions in Sheep Population Based on Meta-Analysis

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