No association between Bach2 gene polymorphisms with Vogt–Koyanagi–Harada syndrome (VKH) and Behcet's disease (BD) in a Chinese Han population

Gao, Xu; Tan, Xiaoyu; Qin, Jieying; Lv, Sha; Hou, Shengping; Kijlstra, Aize; Yang, Peizeng

doi:10.1136/bjophthalmol-2014-306163

Cited by 2 publications

(1 citation statement)

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“…22,53,54 Changes in MMP and TIMP gene expression have also been seen in eyes of people with POAG, and polymorphisms in the genes coding for MMP-1, MMP-2, and MMP-9 and TIMP-1 and TIMP-2 have been associated with both increased and decreased risk of disease in both POAG and PACG in people. [55][56][57][58][59][60][61][62][63][64][65] In dogs, less is known about the roles of MMPs and TIMPs in the eye in health or disease. Mutations in genes coding for other proteins with metalloproteinase activity (ADAMTS10 and ADAMTS17) have been linked with POAG in specific breeds 33,34,[66][67][68] ; however, MMPs and TIMPs themselves have not been evaluated on either a proteomic or genomic level in dogs with POAG.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of matrix metalloproteinases and tissue inhibitors of metalloproteinases in aqueous humor of dogs with versus without naturally occurring primary angle-closure glaucoma

Pumphrey

Zitek-Morrison

Pizzirani

et al. 2022

ajvr

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OBJECTIVE To compare concentrations of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) in aqueous humor from ophthalmologically normal dogs and dogs with naturally occurring primary angle-closure glaucoma (cPACG). SAMPLE Aqueous humor samples from 12 eyes with cPACG and 18 ophthalmologically normal eyes of dogs. PROCEDURES A multiplex fluorescence-based ELISA was used to measure concentrations of MMP-1, MMP-2, MMP-3, MMP-8, MMP-9, MMP-10, MMP-13, TIMP-1, TIMP-2, and TIMP-4. Results for eyes with versus without cPACG were compared. RESULTS Significantly higher mean concentrations of MMP-1 (45% higher), MMP-2 (55% higher), MMP-3 (39% higher), MMP-8 (79% higher), MMP-9 (29% higher), MMP-10 (60% higher), TIMP-1 (63% higher), and TIMP-2 (136% higher) were detected in aqueous humor from eyes with cPACG, compared with ophthalmologically normal eyes. CLINICAL RELEVANCE MMPs and TIMPs have pivotal roles in extracellular matrix turnover and homeostasis in the outflow pathways of the eye. Results of the present study documented higher concentrations of MMPs and TIMPs in aqueous humor samples from dog eyes with late-stage cPACG. Although, to our knowledge, TIMPs have not previously been evaluated in the context of cPACG, the markedly higher concentration of TIMPs in eyes with cPACG suggested that inhibition of proteolysis and extracellular matrix turnover might be a factor in the development of glaucoma in susceptible individuals. However, because the present study used samples from dogs with late-stage cPACG, further work is required to characterize the temporal relationship between MMP and TIMP concentration changes and onset or progression of disease.

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Section: Discussionmentioning

confidence: 99%

Evaluation of matrix metalloproteinases and tissue inhibitors of metalloproteinases in aqueous humor of dogs with versus without naturally occurring primary angle-closure glaucoma

Pumphrey

Zitek-Morrison

Pizzirani

et al. 2022

ajvr

View full text Add to dashboard Cite

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Vogt-Koyanagi-Harada disease: Novel insights into pathophysiology, diagnosis and treatment

Kijlstra

Yang

2016

Progress in Retinal and Eye Research

205

202

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No association between Bach2 gene polymorphisms with Vogt–Koyanagi–Harada syndrome (VKH) and Behcet's disease (BD) in a Chinese Han population

Abstract: This project was registered in the Chinese Clinical Trial Registry (registration number: ChiCTR-CCC-12002184).

Cited by 2 publications

References 31 publications

Evaluation of matrix metalloproteinases and tissue inhibitors of metalloproteinases in aqueous humor of dogs with versus without naturally occurring primary angle-closure glaucoma

Evaluation of matrix metalloproteinases and tissue inhibitors of metalloproteinases in aqueous humor of dogs with versus without naturally occurring primary angle-closure glaucoma

Vogt-Koyanagi-Harada disease: Novel insights into pathophysiology, diagnosis and treatment

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