2021
DOI: 10.1371/journal.pone.0258803
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No association between cataract surgery and mitochondrial DNA damage with age-related macular degeneration in human donor eyes

Abstract: Purpose To determine whether age-related macular degeneration (AMD) severity or the frequency of retinal pigment epithelium mitochondrial DNA lesions differ in human donor eyes that have undergone cataract surgery compared to phakic eyes. Methods Eyes from human donors aged ≥ 55 years were obtained from the Minnesota Lions Eye Bank. Cataract surgery status was obtained from history provided to Eye Bank personnel by family members at the time of tissue procurement. Donor eyes were graded for AMD severity usin… Show more

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