No association between subclinical hypothyroidism and dyslipidemia in children and adolescents

Abstract

Background There are controversies about the correlation between higher levels of thyroid stimulating hormone (TSH) and dyslipidemia in children. This study was designed to assess the relation between lipid profile components and TSH levels in children. Method This cross-sectional study was performed in a pediatric endocrinology growth assessment clinic in Shiraz, southern Iran. Children aged 2–18 years who referred to the clinic from January until April 2018 were included. TSH levels equal or above 5 mIU/L and lower than 10 mIU/L with normal free T4 (FT4) were considered as having subclinical hypothyroidism (SH). Results Six hundred sixty-six children were euthyroid while 181 had SH. No significant difference was found between the mean serum total cholesterol (P = 0.713), LDL-C (P = 0.369), HDL-C (P = 0.211), non-HDL-C (P = 0.929), and triglyceride (P = 0.215) levels between euthyroid children and subjects with SH. There was also no significant difference in the prevalence of dyslipidemias in any lipid profile components between the two groups. The adjusted correlation was not significant between TSH levels and any lipid profile component. Conclusion Based on the results of our study, we found no correlation between SH and dyslipidemia in children. The association between dyslipidemia and SH in children still seems to be inconsistent based on the results of this and previous studies. We recommend a meta-analysis or a significantly larger retrospective study on this subject.

The Impact of Subclinical Hypothyroidism on Lipid Profile in Jeddah

“…On the other hand, the association between hypothyroidism and dyslipidemia is not universal and lack of association is reported in the literature [32,33]. Dyslipidemia plays a role in increased cardiovascular disease in patients with subclinical hypothyroidism [34]. The bene t of treating subclinical hypothyroidism is debated in literature and current guidelines suggest individualised decisions [14,35,36].…”

Effect of Methionine Addition to Soybean Meal Instead of Protein Concentrate in the Finisher Ration of Broiler

“…The absence of THs would increase LDL-c levels in the circulation. Therefore, hypothyroidism causes hypercholesterolemia due to decreased expression of LDL receptors (LDLr) (Habib and Habib, 2020), leading to an imbalance in cholesterol uptake, resulting in a significant increase in Apo lipoprotein B (Apo B), TC and LDL-c levels and decreased clearance of LDL-c and TC in the blood (Duntas and Wartofsky, 2007). In addition, a reduction in clearance of TG levels in circulation as well as aggregation of IDL is due to decreased lipoprotein lipase activity (LPL).…”

Dynamic Observation in Children and Adolescents Following Management of Differentiated Thyroid Cancer

“…Однако имеются исследования, свидетельствующие о вероятной ассоциации гипотиреоза у детей с ухудшением показателей липидного профиля, прироста печеночных ферментов, креатинина, увеличением висцерального жира, что должно быть принято во внимание в индивидуальном порядке [32][33][34][35]. Вероятно, потенцирование нежелательных явлений и снижение качества жизни связано как с длительностью, так и с выраженностью гипотиреоза [36]. В исследовании Habib A. и др.…”

“…В исследовании Habib A. и др. на 847 пациентах возрастом от 2 до 18 лет сообщалось об отсутствии статистически значимого изменения показателей липидного профиля при субклиническом гипотиреозе [36]. Отдельное внимание стоит уделить снижению когнитивных функций, в том числе внимания, памяти, скорости реакции в ответ на повышение уровня ТТГ [37][38][39], что может влиять как на социальное взаимодействие, так и на школьную успеваемость.…”