No associations exists between red blood cell distribution width and serum uric acid in both sexes

Zhang, Chunmei; Meng, Zhaowei; Li, Xue; Liu, Ming; Ren, Xiubao; Zhu, Mei; He, Qing; Zhang, Qing; Song, Kun; Jia, Qiyu; Chen, Qian

doi:10.1097/md.0000000000012707

Cited by 10 publications

(6 citation statements)

References 45 publications

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“…Concurrently, SUA levels reported in this study were lower than those reported in recent largescale studies in Japan (6.0 ± 1.4 and 4.5 ± 1.1 mg/dL in men and women, respectively) [19] and China (6.23 ± 1.38 and 4.38 ± 1.11 mg/dL in men and women, respectively) [20]. A study based in the United States reported that the mean SUA level was 4.4 mg/dL in white women; 4.9 mg/ dL in black women; 5.8 mg/dL in white men; and 6.0 mg/ dL in black men [21]. Therefore, the average SUA level may differ according to sex, race, and place of residence.…”

Section: Discussionmentioning

confidence: 99%

Distribution of serum uric acid levels and prevalence of hyper- and hypouricemia in a Korean general population of 172,970

Koo

Jeong

Son

et al. 2021

Korean J Intern Med

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Background/Aims: We investigated the distribution of serum uric acid (SUA) levels and estimated the prevalence of hyperuricemia and hypouricemia in the Korean population. Methods: This cross-sectional study used data from the Korean Genome and Epidemiology Study and included 172,970 participants (58,981 men and 113,989 women) aged 40 to 79 years. Hypouricemia and hyperuricemia were defined as SUA level ≤ 2.0 mg/dL and > 7 mg/dL, respectively. The prevalence of hyperuricemia and hypouricemia was evaluated by age and sex. Results: The mean SUA levels were significantly higher in men than in women (5.71 ± 1.27 mg/dL vs. 4.21 ± 0.96 mg/dL, p < 0.001). The mean SUA levels and prevalence of hyperuricemia increased with age in women but not in men. The overall prevalence of hyperuricemia and that in men and women was 50.82, 133.25, and 8.17 per 1,000 persons, respectively; the overall prevalence of hypouricemia and that in men and women was 4.16, 1.10, and 5.75 per 1,000 persons, respectively. The prevalence of hypouricemia in men was similar across all age groups; however, that in women was the highest in the age group of 40 to 49 years and the lowest in the age group of 50 to 59 years. Conclusions: The distribution of SUA levels and prevalence of hyperuricemia and hypouricemia differed according to age and sex. Age and sex should be considered in studies on uric acid-related diseases.

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Section: Discussionmentioning

confidence: 99%

Distribution of serum uric acid levels and prevalence of hyper- and hypouricemia in a Korean general population of 172,970

Koo

Jeong

Son

et al. 2021

Korean J Intern Med

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“…Similar to this finding, another study showed that there was no association between RDW in either sex. 57 Conversely to this finding, a larger RDW was associated with a higher risk of morbidity in males compared to females. 37 On the other hand, a study has shown that women have a statistically significantly higher RDW value compared to men.…”

Section: Discussionmentioning

confidence: 75%

“… 56 A study demonstrated no association existed between RDW and sex in either gender. 57 Several genetic risks were previously associated with different traits and diseases and found that most of these, especially those related to cholesterol (both LDL and HDL), triglycerides, systolic blood pressure, BMI, diabetes, and some inflammatory diseases were significantly associated with RDW. 58 However, the importance of RDW scores in screening, diagnosis, and progression of ESRD has not been well researched.…”

Section: Introductionmentioning

confidence: 99%

Distribution Width of Red Blood Cells and Related Factors Among Patients with End-Stage Renal Disease in Addis Ababa, Ethiopia

Melese¹,

Mekonen²,

Aragaw³

et al. 2022

JBM

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Background RDW is critical to the clinical diagnosis and progression of ESRD. There is currently little data on the relationship between RDW and ESRD in sub-Saharan Africa. Because of this, the present study evaluates RDW in patients with ESRD and associated factors in Addis Ababa, Ethiopia. Methods The hospital-based cross-sectional study design was conducted on a total of 83 patients. RDW, MCV, SCR, BUN, GFR, FBS and serum albumin were determined. Blood pressure (mmHg), weight (kg), height (m), MUAC (cm) and BMI (kg/m2) were also measured. Data entry was via Epi-data version 3.4 and analyzed with SPSS version 26.0. A multivariate logistic regression analysis with a p-value < 0.05 at a 95% confidence interval was used to identify the associated factors of RDW. Results A total of 83 ESRD patients participated, with a response rate of 95.4%. RDW ranged from 15.5% to 23.6% with a mean of 17.40% + 1.46%. Anisocytosis was present in 98.8% of patients. Of 83 patients, 66.3% were hypertensive, 20.5% had diabetes, and the remaining 13.3% had other conditions (glomerulonephritis and peripheral vascular disease). The mean GFR value was 5.20 mL/min/1.73 + 1.58. RDW showed a significant association with GFR (AOR: 4.6, 95% CI [1.27, 20.74], P = 0.047), alcohol consumption (AOR: 13.4, P = 0.012, 95% CI [1.97, 22.62]), recurrent kidney disease (AOR=25.6, P=0.016, 95% CI [1.85, 53.71]) and use of medication (AOR=00.2, P=0.044), 95% CI [0.03, 0.95]). Conclusion RDW showed a significant association with GFR, recurrent kidney disease, alcohol consumption, and medication use in hemodialysis-dependent ESRD patients. The mechanisms of RDW disruption in ESRD patients need further investigation.

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“…We used data from a cross‐sectional, community‐based health‐check investigation in Tianjin Medical University General Hospital. The rational and methodology have been reported previously . In brief, a questionnaire was self‐reported by the ostensible healthy participants, who came to our institution for the annual medical checkup.…”

Section: Methodsmentioning

confidence: 99%

Association between platelet distribution width and serum uric acid in Chinese population

et al. 2019

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Platelet distribution width (PDW) is a simple and inexpensive parameter, which could predict activation of coagulation efficiently. And it has been confirmed to have a significant role in many diseases. We aimed to explore the association between PDW and hyperuricemia in a large Chinese cohort. This crosssectional study recruited 61,091 ostensible healthy participants (29,259 males and 31,832 females) after implementing exclusion criteria. Clinical data of the enrolled population included anthropometric measurements and serum parameters. Database was sorted by gender, and the association between PDW and hyperuricemia was analyzed after dividing PDW into quartiles. Crude and adjusted odds ratios of PDW for hyperuricemia with 95% confidence intervals were analyzed using binary logistic regression models. We found no significant difference in PDW values between the genders. Males showed significantly higher incidence of hyperuricemia than females. From binary logistic regression models, significant hyperuricemia risks only were demonstrated in PDW quartiles 2 and 3 in males (P < 0.05). This † Xiaoxia Liu and Huiying Wang as co-first authors contributed equally to this article. BioFactors 326Research Communication study displayed close association between PDW and hyperuricemia as a risk factor. It is meaningful to use PDW as a clinical risk predictor for hyperuricemia in males.

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No associations exists between red blood cell distribution width and serum uric acid in both sexes

Cited by 10 publications

References 45 publications

Distribution of serum uric acid levels and prevalence of hyper- and hypouricemia in a Korean general population of 172,970

Distribution of serum uric acid levels and prevalence of hyper- and hypouricemia in a Korean general population of 172,970

Distribution Width of Red Blood Cells and Related Factors Among Patients with End-Stage Renal Disease in Addis Ababa, Ethiopia

Association between platelet distribution width and serum uric acid in Chinese population

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