No Difference in Catheter Sepsis Between Standard and Antiseptic Central Venous Catheters

Pemberton, L. Beaty; Ross, Vicki M.; Cuddy, Paul G.; Kremer, H.P.H.; Fessler, Theresa A.; McGurk, E

doi:10.1001/archsurg.1996.01430210084018

Cited by 129 publications

(70 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, even if these cases of CRB are excluded, the differences in the rates of bacteremia remain insignificant. These findings are in agreement with 2 recent studies 17,18 evaluating the efficacy of CVCs coated with CSS in patients receiving total parenteral nutrition.…”

Section: 33-35supporting

confidence: 92%

Influence of Triple-Lumen Central Venous Catheters Coated With Chlorhexidine and Silver Sulfadiazine on the Incidence of Catheter-Related Bacteremia

Heard¹,

Wagle²,

Vijayakumar³

et al. 1998

Arch Intern Med

209

117

View full text Add to dashboard Cite

show abstract

Section: 33-35supporting

confidence: 92%

Influence of Triple-Lumen Central Venous Catheters Coated With Chlorhexidine and Silver Sulfadiazine on the Incidence of Catheter-Related Bacteremia

Heard¹,

Wagle²,

Vijayakumar³

et al. 1998

Arch Intern Med

209

117

View full text Add to dashboard Cite

show abstract

“…Other studies that have demonstrated a reduced rate of skin colonization and bacteremias include those involving catheters coated with chorhexidine-silver sulfadiazine (21,22,42,43) or minocycline and rifampin (20). These studies are limited by their short-term catheterization and efficacy (42), reduced antimicrobial activity over time (43,44), potential for microbial resistance (45), and generalizability to the chronic hemodialysis population.…”

Section: Discussionmentioning

confidence: 99%

Hemodialysis Infection Prevention with Polysporin Ointment

Lok

Stanley

Hux³

et al. 2003

Journal of the American Society of Nephrology

160

110

View full text Add to dashboard Cite

Abstract. Hemodialysis patients in whom permanent vascular access cannot be achieved are dependent on a central venous catheter. In such patients, catheter-related infections are a common and serious complication. This study was a randomized clinical trial to determine if topical Polysporin Triple antibiotic ointment applied to the central venous catheter insertion site could reduce the incidence of catheter-related infections. A total of 169 patients receiving hemodialysis through a central venous catheter were randomized to receive Polysporin Triple or placebo using a double-blind study design. In the 6-mo study period, infections were observed in more patients in the placebo group than in the Polysporin Triple group (34 versus 12%; relative risk, 0.35; 95% CI, 0.18 to 0.68; P ϭ 0.0013). The number of infections per 1000 catheter days (4.10 versus 1.02; P Ͻ 0.0001) and the number of bacteremias per 1000 catheter days (2.48 versus 0.63; P ϭ 0.0004) were also greater in the placebo group. Within the 6-mo study period, there were 13 deaths in the placebo group as compared with 3 deaths in the Polysporin Triple group (P ϭ 0.0041). When all available follow-up information was included, the difference in survival remained significant (19 versus 9 deaths; P ϭ 0.0027). Within the first 6 mo, infections were observed in 7 of the 13 placebo subjects who died (54%) as compared with no infections in the three Polysporin Triple subjects who died. The prophylactic application of topical Polysporin Triple antibiotic ointment to the central venous catheter insertion site reduced the rate of infections and was associated with improved survival in hemodialysis patients. charmaine.lok@uhn.on.caInfection is the most common cause of morbidity and the second most common cause of death in hemodialysis (HD) patients (1-5). Bacteremia accounts for more than 75% of these infectious deaths (4). Hemodialysis vascular access is implicated as the source of bacteremias in 48 to 73% (3,6 -7) of cases with patients dependent on central venous catheters (CVC) being at highest risk (2,7-9). Currently, approximately 20% of patients are dialyzed using permanent catheters; both their placement rate and length of use has increased (1,4). Staphylococcus aureus has previously been the primary etiologic agent implicated in causing approximately half of the bacteremic episodes (7,10) and 70% of the vascular access site infections (11-12). However, recent studies have reported a greater percentage and variety of Gram-negative bacteria isolated in catheter-related infections (13-16). Polysporin Triple (PT) is an antibiotic ointment composed of 500 U/g bacitracin, 0.25 mg/g gramicidin, and 10,000 U/g polymyxin B and is active topically against most skin flora (e.g., S. aureus, coagulase negative staphylococcus, and most Gram-negative bacteria). Previous studies have demonstrated success in preventing catheter-related infections using topical povidone-iodine (17) or mupirocin (12,18,19), antibiotic or silver-coated catheters (20 -22), and other novel metho...

show abstract

“…Authors were contacted for these nine studies; no more information was available for three, 11,54,60 no reply was received from four 53,61,65,72 and two authors said that they did not investigate either CRBSI or colonisation.…”

Section: Bias-funnel Plotsmentioning

confidence: 99%

The clinical effectiveness and cost-effectiveness of central venous catheters treated with anti-infective agents in preventing bloodstream infections: a systematic review and economic evaluation

Hockenhull¹,

Dwan²,

Boland³

et al. 2008

Health Technol Assess

View full text Add to dashboard Cite

Non-UK purchasers will have to pay a small fee for post and packing. For European countries the cost is £2 per monograph and for the rest of the world £3 per monograph.You can order HTA monographs from our Despatch Agents:-fax (with credit card or official purchase order) -post (with credit card or official purchase order or cheque) -phone during office hours (credit card only).Additionally the HTA website allows you either to pay securely by credit card or to print out your order and then post or fax it. NHS libraries can subscribe free of charge. Public libraries can subscribe at a very reduced cost of £100 for each volume (normally comprising 30-40 titles). The commercial subscription rate is £300 per volume. Please see our website for details. Subscriptions can only be purchased for the current or forthcoming volume. Contact details are as follows: Payment methods Paying by chequeIf you pay by cheque, the cheque must be in pounds sterling, made payable to Direct Mail Works Ltd and drawn on a bank with a UK address. Paying by credit cardThe following cards are accepted by phone, fax, post or via the website ordering pages: Delta, Eurocard, Mastercard, Solo, Switch and Visa. We advise against sending credit card details in a plain email. Paying by official purchase orderYou can post or fax these, but they must be from public bodies (i.e. NHS or universities) within the UK. We cannot at present accept purchase orders from commercial companies or from outside the UK. How do I get a copy of HTA on CD?Please use the form on the HTA website (www.hta.ac.uk/htacd.htm). Or contact Direct Mail Works (see contact details above) by email, post, fax or phone. HTA on CD is currently free of charge worldwide.The website also provides information about the HTA Programme and lists the membership of the various committees. HTA NIHR Health Technology Assessment ProgrammeT he Health Technology Assessment (HTA) Programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care. The research findings from the HTA Programme directly influence decision-making bodies such as the National Institute for Health and Clinical Excellence (NICE) and the National Screening Committee (NSC). HTA findings also help to improve the quality of clinical practice in the NHS indirectly in that they form a key component of the 'National Knowledge Service'. The HTA Programme is needs-led in that it fills gaps in the evidence needed by the NHS. There are three routes to the start of projects. First is the commissioned route. Suggestions for research are actively sought from people working in the NHS, the public and consumer groups and professional bodies such as royal colleges and NHS trusts. These sugges...

show abstract

No Difference in Catheter Sepsis Between Standard and Antiseptic Central Venous Catheters

Cited by 129 publications

References 6 publications

Influence of Triple-Lumen Central Venous Catheters Coated With Chlorhexidine and Silver Sulfadiazine on the Incidence of Catheter-Related Bacteremia

Influence of Triple-Lumen Central Venous Catheters Coated With Chlorhexidine and Silver Sulfadiazine on the Incidence of Catheter-Related Bacteremia

Hemodialysis Infection Prevention with Polysporin Ointment

The clinical effectiveness and cost-effectiveness of central venous catheters treated with anti-infective agents in preventing bloodstream infections: a systematic review and economic evaluation

Contact Info

Product

Resources

About