No gender differences in the pharmacological emergency treatment of schizophrenia: results of a 21-year observation

Abstract

Patients suffering from schizophrenia are at high risk for admission and treatment in locked units. This study investigated gender differences in the pharmacological emergency treatment of schizophrenia patients over a 21-year observation period. The current retrospective study was conducted at the Division of Psychiatry I of the Medical University Innsbruck. All adult patients (n = 845; 425 female) suffering from schizophrenia who were admitted involuntarily to one of the acute psychiatric units in the years 1997, 2002, 2007, 2012 and 2017 were included in the study. In the years mentioned above, 590 schizophrenia patients (297 men, 293 women) admitted to a locked unit received pharmacological emergency treatment. With the exception of clozapine which was more frequently administered to men no significant differences between men and women were found in terms of the choice, dosage, and type of application of medication (antipsychotics and benzodiazepines). Since most treatment guidelines for schizophrenia do not consider gender differences at all, it is not surprising that acute treatment is almost the same for men and women. However, in times when individualized therapies gain more and more importance, the consideration of sex differences should be part of new treatment concepts.

Focus on antipsychotics and related therapeutic drug monitoring

“…Indeed, there are few studies investigating optimal treatment options based on sex (Crawford and DeLisi, 2016). A study in this issue reports data from emergency inpatient treatment of men and women over a 21-year time span (Edlinger et al , 2023). The results suggest that there is little or no difference between men and women in terms of the drugs used, doses or routes of administration.…”