No Small Matter: A Perspective on Nanotechnology-Enabled Solutions to Fight COVID-19

Jones, Georgia Wilson; Monopoli, Marco P.; Campagnolo, Luisa; Pietroiusti, Antonio; Tran, Lang; Fadeel, Bengt

doi:10.2217/nnm-2020-0286

Cited by 22 publications

(19 citation statements)

References 158 publications

(195 reference statements)

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“…Likewise, nanotechnology and nanoscience may open new windows in combating various pathogens including COVID‑19, in different ways such as detecting the virus, diagnosis of viral infection and nano-vaccines, such as lipid nanoparticles, for the prevention and/or the therapy of COVID-19 infection [118] , [119] , [120] , [121] , [122] , [123] , [124] , [125] , [126] , [127] , [128] , [129] .…”

Section: Application Of Nanotechnology In Virus Therapymentioning

confidence: 99%

Antiviral performance of graphene-based materials with emphasis on COVID-19: A review

Seifi

Kamali

2021

Medicine in Drug Discovery

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Coronavirus disease-2019 has been one of the most challenging global epidemics of modern times with a large number of casualties combined with economic hardships across the world. Considering that there is still no definitive cure for the recent viral crisis, this article provides a review of nanomaterials with antiviral activity, with an emphasis on graphene and its derivatives, including graphene oxide, reduced graphene oxide and graphene quantum dots. The possible interactions between surfaces of such nanostructured materials with coronaviruses are discussed. The antiviral mechanisms of graphene materials can be related to events such as the inactivation of virus and/or the host cell receptor, electrostatic trapping and physico-chemical destruction of viral species. These effects can be enhanced by functionalization and/or decoration of carbons with species that enhances graphene-virus interactions. The low-cost and large-scale preparation of graphene materials with enhanced antiviral performances is an interesting research-direction to be explored.

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Section: Application Of Nanotechnology In Virus Therapymentioning

confidence: 99%

Antiviral performance of graphene-based materials with emphasis on COVID-19: A review

Seifi

Kamali

2021

Medicine in Drug Discovery

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“…New therapeutics and vaccines can be given by nanotechnology to counter the current pandemic; nanomedicines, though, need to be proved secure first, as all modern treatments [ 287 ]. Also, they should be well tested before launching in the market.…”

Section: Nanomedicine Solutions (Nanotechnology)mentioning

confidence: 99%

Nanomedicine for COVID-19: the role of nanotechnology in the treatment and diagnosis of COVID-19

Vahedifard

Chakravarthy

2021

emergent mater.

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused the recent outbreak of coronavirus 2019 (COVID-19). Although nearly two decades have passed since the emergence of pandemics such as SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV), no effective drug against the CoV family has yet been approved, so there is a need to find newer therapeutic targets. Currently, simultaneous research across the globe is being performed to discover efficient vaccines or drugs, including both conventional therapies used to treat previous similar diseases and emerging therapies like nanomedicine. Nanomedicine has already proven its value through its application drug delivery and nanosensors in other diseases. Nanomedicine and its components can play an important role in various stages of prevention, diagnosis, treatment, vaccination, and research related to COVID-19. Nano-based antimicrobial technology can be integrated into personal equipment for the greater safety of healthcare workers and people. Various nanomaterials such as quantum dots can be used as biosensors to diagnose COVID-19. Nanotechnology offers benefits from the use of nanosystems, such as liposomes, polymeric and lipid nanoparticles, metallic nanoparticles, and micelles, for drug encapsulation, and facilitates the improvement of pharmacological drug properties. Antiviral functions for nanoparticles can target the binding, entry, replication, and budding of COVID-19. The toxicity-related inorganic nanoparticles are one of the limiting factors of its use that should be further investigated and modified. In this review, we are going to discuss nanomedicine options for COVID-19 management, similar applications for related viral diseases, and their gap of knowledge.

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“…Another study has shown promising use of flavonoids against SARS-CoV-2 using molecular docking approaches [61] . The concern of synthetic nanomaterials use could be eliminated by employing nanoparticles arising from phyto actives [ 62 , 63 ]. Moreover, these compounds themselve can potentiate the anti-COVID-19 activity.…”

Section: Ivermectin and Covid-19mentioning

confidence: 99%

COVID-19 and Ivermectin: Potential threats associated with human use

Zaheer

Pal

Abbas

et al. 2021

Journal of Molecular Structure

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Drugs re-purposing due to COVID-19 has declared a number of useful candidates for treatment and prevention of the virus. Ivermectin (IVM) has gained much popularity due to a strong background of magical applications against a broad spectrum of pathogens. The in vitro studies of ivermectin have shown promise, the thorough clinical trials of its efficacy in the treatment and prevention of SARS-CoV-2 are still warranted. Useful strategies for analyzing projected use of IVM in human coronaviruses might be developed. This may be done by concluding ongoing clinical trials and culturing lessons from IVM usage in veterinary practice. The potential toxicity and careful dosage analyses are urgently required before declaring it as an anti-SARS-CoV-2 drug candidate. This paper overviews the background and potential threats associated with the off-label use of IVM as prophylactic drug or treatment option against COVID-19.

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No Small Matter: A Perspective on Nanotechnology-Enabled Solutions to Fight COVID-19

Cited by 22 publications

References 158 publications

Antiviral performance of graphene-based materials with emphasis on COVID-19: A review

Antiviral performance of graphene-based materials with emphasis on COVID-19: A review

Nanomedicine for COVID-19: the role of nanotechnology in the treatment and diagnosis of COVID-19

COVID-19 and Ivermectin: Potential threats associated with human use

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