Nocardia nova Aortitis After Coronary Artery Bypass Surgery

Liff, David; Kraft, Colleen S.; Pohlel, Khan; Wade, J. D.; Franco‐Paredes, Carlos; Chen, Edward P.; Clements, Stephen D.; Sperling, Laurence

doi:10.1016/j.echo.2006.10.018

Cited by 5 publications

(1 citation statement)

References 4 publications

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“…Pulmonary infection is most common, accounting for almost 82% of the cases as reported from Australia, 42 but hematogenous dissemination to other organs is possible, as there are cases of brain abscesses, 44 aortitis, 45 and endophthalmitis, 46 following Nocardia infection. Clinical and radiological manifestations are just like tuberculosis or malignancy, which include pneumonia and infiltrative or nodular lesions, which may be accompanied by cavitation, abscess formation, pleural effusions, or empyema and sometimes mass-like lesions.…”

Section: Organs Affectedmentioning

confidence: 99%

Uncommon Pathogens Causing Hospital-Acquired Infections in Postoperative Cardiac Surgical Patients

et al. 2019

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Bacterial infections are common causes of sepsis in the intensive care units. However, usually a finite number of Gram-negative bacteria cause sepsis (mostly according to the hospital flora). Some organisms such as Escherichia coli, Acinetobacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Staphylococcus aureus are relatively common. Others such as Stenotrophomonas maltophilia, Chryseobacterium indologenes, Shewanella putrefaciens, Ralstonia pickettii, Providencia, Morganella species, Nocardia, Elizabethkingia, Proteus, and Burkholderia are rare but of immense importance to public health, in view of the high mortality rates these are associated with. Being aware of these organisms, as the cause of hospital-acquired infections, helps in the prevention, treatment, and control of sepsis in the high-risk cardiac surgical patients including in heart transplants. Therefore, a basic understanding of when to suspect these organisms is important for clinical diagnosis and initiating therapeutic options. This review discusses some rarely appearing pathogens in our intensive care unit with respect to the spectrum of infections, and various antibiotics that were effective in managing these bacteria.

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Section: Organs Affectedmentioning

confidence: 99%

Uncommon Pathogens Causing Hospital-Acquired Infections in Postoperative Cardiac Surgical Patients

et al. 2019

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Management of nocardia associated infected ruptured paravisceral aortic aneurysm with preserved allograft and long-term antimicrobial suppression

Alslaim

2022

Annals of Vascular Surgery - Brief Reports and Innovations

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Nocardia bacteremia: A single-center retrospective review and a systematic review of the literature

Williams

Jenney

Spelman

2020

International Journal of Infectious Diseases

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Objectives: Nocardia bacteremia is a rare but severe disease associated with high mortality. This systematic review is the largest and most comprehensive review performed over the past 20 years. Methods: A single-center retrospective review of Nocardia bacteremia was performed using hospital microbiology records from January 1, 2010 to December 31, 2017. A systematic literature review was also performed to identify cases of Nocardia bacteremia described in the NCBI PubMed database in English between January 1, 1999 and December 31, 2018. Results: Four new cases of Nocardia bacteremia are described. The systematic review identified 134 cases with sufficient information available for analysis. Of the total 138 cases, the median age was 58 years (interquartile range (IQR) 44-69 years) and 70% were male. Eighty-one percent were immunocompromised (corticosteroid use (49%), hematological malignancy (20%), solid organ transplant (20%), solid organ malignancy (19%), and hematopoietic stem cell transplantation (15%)) and 29% had endovascular devices. Pulmonary infection was the most common concurrent site of clinical disease (67%). The median incubation time to the detection of Nocardia bacteremia was 4 days (IQR 3-6 days). Blood cultures were the only positive microbiological specimen in 38% of cases. The median total duration of treatment was 75 days (IQR 25-182 days). Thirty-day all-cause mortality was 28% and overall all-cause mortality was 40%. Conclusions: Nocardia bacteremia is most frequently identified in immunocompromised patients and those with intravascular devices. Although rare, it represents a serious infection with high associated overall mortality.

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Nocardia nova Aortitis After Coronary Artery Bypass Surgery

Cited by 5 publications

References 4 publications

Uncommon Pathogens Causing Hospital-Acquired Infections in Postoperative Cardiac Surgical Patients

Uncommon Pathogens Causing Hospital-Acquired Infections in Postoperative Cardiac Surgical Patients

Management of nocardia associated infected ruptured paravisceral aortic aneurysm with preserved allograft and long-term antimicrobial suppression

Nocardia bacteremia: A single-center retrospective review and a systematic review of the literature

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