Nodal degree changes induced by electroconvulsive therapy in major depressive disorder: Evidence in two independent cohorts

Wu, Yue; Ji, Yang; Bai, Tongjian; Wei, Qiang; Zu, Meidan; Guo, Yuanyuan; Lv, Huaming; Zhang, Aiguo; Qiu, Bensheng; Wang, Kai; Tian, Yanghua

doi:10.1016/j.jad.2022.03.045

Cited by 5 publications

(2 citation statements)

References 42 publications

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“…According to graph theory, nodes (brain regions) were the cores of a functional network, which could be measured by nodal degree centrality and nodal efficiency. The nodal degree centrality and efficiency were usually used to identify network hubs, which were critical for establishing and maintaining efficient information transfer across regions (Bullmore & Sporns, 2009 ; Wu et al, 2022 ). Statistical analysis showed that nodal degree centrality (Figure 6a ) and nodal efficiency (Figure 7a ) of Wernicke's area was higher in the older adults compared with the young adults.…”

Section: Discussionmentioning

confidence: 99%

Aging effects on dual‐route speech processing networks during speech perception in noise

Wang,

Chen,

Liu

et al. 2024

Human Brain Mapping

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Healthy aging leads to complex changes in the functional network of speech processing in a noisy environment. The dual‐route neural architecture has been applied to the study of speech processing. Although evidence suggests that senescent increases activity in the brain regions across the dorsal and ventral stream regions to offset reduced periphery, the regulatory mechanism of dual‐route functional networks underlying such compensation remains largely unknown. Here, by utilizing functional near‐infrared spectroscopy (fNIRS), we investigated the compensatory mechanism of the dual‐route functional connectivity, and its relationship with healthy aging by using a speech perception task at varying signal‐to‐noise ratios (SNR) in healthy individuals (young adults, middle‐aged adults, and older adults). Results showed that the speech perception scores showed a significant age‐related decrease with the reduction of the SNR. The analysis results of dual‐route speech processing networks showed that the functional connection of Wernicke's area and homolog Wernicke's area were age‐related increases. Further to clarify the age‐related characteristics of the dual‐route speech processing networks, graph‐theoretical network analysis revealed an age‐related increase in the efficiency of the networks, and the age‐related differences in nodal characteristics were found both in Wernicke's area and homolog Wernicke's area under noise environment. Thus, Wernicke's area might be a key network hub to maintain efficient information transfer across the speech process network with healthy aging. Moreover, older adults would recruit more resources from the homologous Wernicke's area in a noisy environment. The recruitment of the homolog of Wernicke's area might provide a means of compensation for older adults for decoding speech in an adverse listening environment. Together, our results characterized dual‐route speech processing networks at varying noise environments and provided new insight for the compensatory theories of how aging modulates the dual‐route speech processing functional networks.

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Section: Discussionmentioning

confidence: 99%

Aging effects on dual‐route speech processing networks during speech perception in noise

Wang,

Chen,

Liu

et al. 2024

Human Brain Mapping

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“…However, interestingly, it appears to be involved in the brain response to ECT. For instance, following ECT, the RSFC of the angular gyrus with the rest of the brain is increased (Wu et al, 2022;Wei et al, 2018). ECT has also been shown to increase spontaneous brain activity in the angular gyrus (Mo et al, 2020).…”

Section: Dmn Regionsmentioning

confidence: 99%

The Habenula in Mood Disorders: A Scoping Review of Human Studies

Fortin,

Lafleur,

Parisien

et al. 2024

Preprint

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In animal models, the habenula has been identified as a key structure involved in depression. Thanks to recent technological advancements, a burgeoning body of work has also investigated the habenula in the context of human mood disorders. This scoping review aims to synthesize findings from human studies that pertain to the habenula and its relationship with mood disorders. The review was conducted according to PRISMA guidelines. The literature search was performed with PubMed and yielded 93 articles, of which 50 articles were included in the review. We found that the evidence for baseline habenular hyperactivity in human depression is mixed. As for findings from resting-state functional connectivity (RSFC) studies, they were mainly inconsistent across studies. Moreover, we found no evidence indicating that mood disorders are linked to changes in the volume of the habenula. In order to enhance the replicability of findings, given the small size of the habenula, higher image resolution and larger samples are recommended for future studies.

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Trajectory of associative memory impairment during electroconvulsive therapy in depression

Ji,

Huang,

Zheng

et al. 2024

Journal of Psychiatric Research

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Nodal degree changes induced by electroconvulsive therapy in major depressive disorder: Evidence in two independent cohorts

Cited by 5 publications

References 42 publications

Aging effects on dual‐route speech processing networks during speech perception in noise

Aging effects on dual‐route speech processing networks during speech perception in noise

The Habenula in Mood Disorders: A Scoping Review of Human Studies

Trajectory of associative memory impairment during electroconvulsive therapy in depression

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