Nodal involvement as an indicator of postoperative liver metastasis in carcinoma of the papilla of Vater

Moriya, Tôru; Kimura, Wataru; Hirai, Ichiro; Mizutani, Masaomi; Ma, Jingfeng; Kamiga, Masahiro; Fuse, Akira

doi:10.1007/s00534-006-1113-5

Cited by 19 publications

(23 citation statements)

References 29 publications

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“…Sakata et al reported that survival outcome was significantly worsened in the following order: patients with negative lymph node metastasis, patients with 1-3 metastatic lymph nodes, and patients with ≥ 4 metastatic regional nodes (16). Large tumor size (14,26), pancreatic invasion (5,24), ulcer formation and tumor differentiation (15), higher recurrent rate of liver metastasis following surgery (15) were significantly correlated with lymph node metastasis. The patients who had lymph node metastasis did not demonstrate significantly poorer survival in our study.…”

Section: Discussionmentioning

confidence: 99%

Surgical Outcomes and Prognostic Factors for Ampulla of Vater Cancer

et al. 2011

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Background and Aims: the prognosis for patients with ampulla of Vater cancer is better than other periampullary cancers. the aim of the present study is to determine the clinicopathologic factors predictive of survival and recurrence in patients with ampulla of Vater cancer.Material and Methods: from 1991 to 2008, we identified and reviewed 78 patients with ampulla of Vater cancer retrospectively. clinicopathologic factors possibly influencing survival and recurrence were statistically analyzed.Results: pancreaticoduodenectomy was performed in 68 patients and 2 patients underwent transduodenal ampullectomy. Hospital mortality was 2.6%. the 5-year survival rates following resection were 59.9%. univariate analysis for overall survival revealed that total bilirubin greater than 5mg/dl, ulcerative tumors, differentiation, and pancreatic invasion were significant prognostic factors. recurrence occurred in 31 patients. univariate analysis for disease-free survival revealed that total bilirubin greater than 5mg/ dl, preoperative biliary drainage, tumor differentiation, and stage were statistically significant. multivariate analysis revealed that tumor differentiation was an independent prognostic factor for recurrence. the presence of lymph node metastasis did not affect overall survival significantly in this study. However, two or more metastatic lymph nodes significantly affect disease-free survival.Conclusions: pancreaticoduodenectomy is a safe surgical procedure with acceptable long-term survival for ampulla of Vater cancer. pancreaticoduodenectomy with lymph node dissection might control lymph node spread and enhance survival outcome.

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Section: Discussionmentioning

confidence: 99%

Surgical Outcomes and Prognostic Factors for Ampulla of Vater Cancer

et al. 2011

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“…The endoscopic ultrasound-guided fine-needle aspiration biopsy revealed adenocarcinoma of the duodenal papilla. Standard pancreaticoduodenectomy usually is the primary treatment for duodenal papilla carcinoma (28)(29)(30). However, considering the patient's age and poor performance status, a palliative endoscopic retrograde biliary stent placement drainage was performed to relieve his biliary obstruction.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and Treatment of Synchronous Lymphoma and Digestive System Carcinoma: Report of Four Cases and Literature Review

Meng

Liu

et al. 2019

Front. Oncol.

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Objective: To investigate the diagnosis and treatment of synchronous lymphoma and digestive system carcinoma and review literature. Materials and Methods: We retrospectively analyzed the clinical data of four cases of synchronous lymphoma and digestive system carcinoma treated at our hospital. The clinical manifestations, pathological results, and treatment strategies were investigated. Results: One of the four cases was diagnosed as follicular lymphoma with gastric adenocarcinoma, and the other three were diagnosed as diffuse large B-cell lymphoma with digestive system adenocarcinoma in the liver, sigmoid colon, and duodenum papilla, respectively. The second carcinoma was initially discovered incidentally because of the stage examination of lymphoma or the patient's poor response to treatment. The diagnosis of synchronous lymphoma and digestive system carcinoma depended mainly on the pathological examination. Conclusions: The accurate diagnosis of synchronous malignancies is challenging because they rarely occur. We suggest a scrupulous re-biopsy of extranodal lesions in patients with lymphoma to improve the diagnostic accuracy of related double primary tumors. Age, performance status, symptoms, pathological types, and tumor staging should be considered when formulating a treatment strategy. The systemic treatment regimens should include drugs targeting the synchronous tumors in question, and these remain to be explored further.

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“…The prognosis of ampullary carcinoma is relatively better than that of other biliary tract cancers after surgical resection [10]. Lymph node metastasis and pancreatic invasion are important prognostic factors [4,11]. Beger et al [12] reported that lymph node involvement was observed in about 10% of patients with a pT1 carcinoma of the papilla.…”

Section: Discussionmentioning

confidence: 99%

Gallbladder perforation associated with carcinoma of the duodenal papilla: a case report

et al. 2010

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BackgroundGallbladder perforation is a rare clinical condition, which mostly occurs following acute cholecystitis associated with cholelithiasis. A tumor of the ampulla of Vater causes gradually progressive symptoms, and is rarely associated with perforation of the gallbladder.Case PresentationA 56-year-old man with carcinoma of the ampulla of Vater presented with spontaneous gallbladder perforation and localized bile peritonitis. He complained of right upper abdominal pain, and laparotomy revealed perforation of the gallbladder with no gallstones. Postoperative upper gastrointestinal endoscopy demonstrated a slightly enlarged duodenal papilla, and biopsy revealed adenocarcinoma of the ampulla. Pylorus-preserving pancreaticoduodenectomy was performed subsequently.ConclusionAmpullary carcinoma can be associated with gallbladder perforation and present with acute manifestations. Immediate surgical treatment is required for this condition.

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Nodal involvement as an indicator of postoperative liver metastasis in carcinoma of the papilla of Vater

Cited by 19 publications

References 29 publications

Surgical Outcomes and Prognostic Factors for Ampulla of Vater Cancer

Surgical Outcomes and Prognostic Factors for Ampulla of Vater Cancer

Diagnosis and Treatment of Synchronous Lymphoma and Digestive System Carcinoma: Report of Four Cases and Literature Review

Gallbladder perforation associated with carcinoma of the duodenal papilla: a case report

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