Nodular Gastritis and Helicobacter pylori

Bujanover, Yoram; Konikoff, Fred M.; Baratz, M

doi:10.1097/00005176-199007000-00008

Cited by 97 publications

(75 citation statements)

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“…6,11,16,22 However, the endoscopic appearance for defi ning NG has not yet been well established. The reported incidence of this nodularity varies con siderably and is 30%-100% in H. pylori-positive children.…”

Section: Discussionmentioning

confidence: 99%

“…The reported incidence of this nodularity varies con siderably and is 30%-100% in H. pylori-positive children. 4,[6][7][8]10,11,16 In our study, we divided NG into two types, diffuse and nondiffuse, by the distribution of nodular or granular elevated lesions in the antrum. Nondiffuse-type NG presents with scattered or localized distribution of nodular or granular elevated lesions in the antrum.…”

Section: Discussionmentioning

confidence: 99%

“…[1][2][3] Since the discovery of H. pylori by Marshall and Warren, 1 many studies have found a strong association between nodular gastritis (NG) and H. pylori infection in children. [4][5][6][7][8][9][10][11][12][13][14][15][16] However, the infl ammation of the gastric mucosa caused by H. pylori is not always observed macroscopically. This nodularity can be seen in the stomach of children much more frequently than in adults and may be a characteristic of an early stage of infection with H. pylori.…”

Section: Introductionmentioning

confidence: 99%

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Nodular gastritis in Japanese young adults: endoscopic and histological observations

Shiotani

Kamada

Kumamoto³

et al. 2007

J Gastroenterol

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Nodular gastritis in Japanese young adults: endoscopic and histological observations

Shiotani

Kamada

Kumamoto³

et al. 2007

J Gastroenterol

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“…Antral nodularity was reported to be unique to children with H pylori infection 26 ; however, it is not uncommon in young adults. Sbeih and coworkers 27 found a very low success rate (38%) in their study on treatment with standard triple therapy (bismuth subcitrate, tetracycline, and metronidazole for 2 weeks) in a young adult patient group with nodular gastritis.…”

Section: Discussionmentioning

confidence: 99%

One-Week Triple Therapy With Omeprazole, Clarithromycin, and Nitroimidazole forHelicobacter pyloriInfection in Children and Adolescents

Moshkowitz¹,

Reif

Brill³

et al. 1998

Pediatrics

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ABSTRACT. Background. Resolution of Helicobacter pylori infection is important in the management of peptic ulcer disease and reduces peptic ulcer recurrence in both adults and children. Various anti-H pylori treatment regimens have been proposed, reflecting the incomplete clinical success of each. A combination of omeprazole, clarithromycin, and tinidazole, given for 1 week, has been shown to be highly tolerable and effective, achieving a success rate of >90% in the adult population.Objective. The aim of this study was to evaluate this short-term regimen in pediatric and adolescent populations.Methods. The study group consisted of 35 children referred for evaluation of dyspeptic symptoms. They all underwent upper gastrointestinal endoscopy, in which H pylori infection was confirmed by rapid urease test and/or histologic staining. They were given omeprazole (20 mg twice daily), clarithromycin (250 mg twice daily), and tinidazole or metronidazole (500 mg twice daily) for 1 week. The patients were divided into two groups: those who received the first course of anti-H pylori therapy during this study (group 1) and those who had previously received standard metronidazole and bismuth combination therapies that failed to eradicate H pylori (group 2). Therapeutic efficacy was assessed by a 13 C-urea breath test performed 4 weeks after completion of treatment.Results. The 35 study patients had a mean age of 15.9 years (range, 10 to 19) and included 19 males and 16 females, of whom 22 were born in Israel and 13 were immigrants from the former USSR. There were 27 patients (77.1%) in group 1 and 8 patients (22.9%) in group 2. Endoscopic findings were nodular gastritis (14), gastritis (11), gastric ulcer (1), duodenal ulcer (5), and duodenitis (4). H pylori resolution was significantly higher in group 1 patients (24/27, 88.9%) than in group 2 patients (1/8, 12.5%). There was no difference between patients with nodular gastritis and those with nonnodular gastritis, and between Israeli-born patients and patients born in the former USSR. Compliance in both groups was equally good, and no major side effects were recorded.Conclusions. One-week omeprazole/clarithromycin/ tinidazole triple therapy is highly tolerable and effective for treating H pylori in the pediatric age group, but previous treatment failure diminishes the likelihood of success with this regimen. Pediatrics 1998;102(1). URL: http://www.pediatrics.org/cgi/content/full/102/1/e14; Helicobacter pylori, triple therapy, children, adolescents, omeprazole, clarithromycin.

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“…Nodular gastritis is often observed in children, particularly those with DU without mucosal atrophy. 55 Animals studies indicate that among various mouse strains, only Balb/c mice, a Th2-predominant strain, develop nodular gastritis due to H. pylori infection after neonatal thymectomy, and that Th2-type cytokines, including IL-4, have important roles in the development of nodular gastritis, in contrast to C57/black mice, a Th1-predominant strain, which develop active pangastritis following H. pylori infection. 34,37 Thus, because nodular gastritis develops under the background of Th2-type immune response and is not associated with mucosal atrophy, nodular gastritis does not appear to be linked to the development of gastric cancer, particularly intestinal-type gastric cancer.…”

Section: Gastric Cancermentioning

confidence: 99%

Host factors are important in determining clinical outcomes of Helicobacter pylori infection

et al. 2006

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Nodular Gastritis and Helicobacter pylori

Cited by 97 publications

References 0 publications

Nodular gastritis in Japanese young adults: endoscopic and histological observations

Nodular gastritis in Japanese young adults: endoscopic and histological observations

One-Week Triple Therapy With Omeprazole, Clarithromycin, and Nitroimidazole forHelicobacter pyloriInfection in Children and Adolescents

Host factors are important in determining clinical outcomes of Helicobacter pylori infection

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