Nodular Glomerulosclerosis in the Nondiabetic Smoker

Nasr, Samih H.; D’Agati, Vivette D.

doi:10.1681/asn.2006121328

Cited by 65 publications

(61 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fewer than 50 cases have been documented in the literature so far (76). Median time from biopsy to ESRD is only 26 mo in one series (77). In cases of rapid CKD progression in heavy smokers, even in those who quit several years before (77) or do not have other risk factors that might result in vascular injury (78), this disease should be considered.…”

Section: Histopathologic Features Of Smoking-induced Renal Damagementioning

confidence: 99%

See 1 more Smart Citation

Smoking

Orth

Hallan²

2008

Clinical Journal of the American Society of Nephrology

256

174

View full text Add to dashboard Cite

Although it is beyond any doubt that smoking is the number one preventable cause of death in most countries, smoking as an independent progression factor in renal disease has been questioned against the background of evidence-based criteria. This is because information from large, randomized, prospective studies that investigate the effects of smoking on renal function in healthy individuals as well as in patients with primary or secondary renal disease are lacking. Since 2003, a substantial number of clinical and experimental data concerning the adverse renal effects of smoking have been published, including large, prospective, population-based, observational studies. These more recent data together with evidence from experimental studies clearly indicate that smoking is a relevant risk factor, conferring a substantial increase in risk for renal function deterioration. This review summarizes the present knowledge about the renal risks of smoking as well as the increased cardiovascular risk caused by smoking in patients with chronic kidney disease. The conclusion is that smoking is an important renal risk factor, and nephrologists have to invest more efforts to motivate patients to stop smoking.

show abstract

Section: Histopathologic Features Of Smoking-induced Renal Damagementioning

confidence: 99%

“…Nasr and D'Agati (77) proposed to term this entity "smokingassociated nodular glomerulosclerosis," because the term "idiopathic" does not stand against the evidence of the strong association of nodular glomerulosclerosis with smoking.…”

Section: Histopathologic Features Of Smoking-induced Renal Damagementioning

confidence: 99%

Smoking

Orth

Hallan²

2008

Clinical Journal of the American Society of Nephrology

256

174

View full text Add to dashboard Cite

show abstract

“…It increases the risk of albuminuria, progression to proteinuria, and renal functional impairment, particularly in men and the elderly. The pathophysiologic mechanisms include the formation of advanced glycation end-products (AGEs) by glycotoxins, induction of oxidative stress, angiogenesis, and altered intrarenal hemodynamics (7,8). Induction of oxidative stress by free radicals contained in cigarette smoke and directly by AGE increases ECM.…”

Section: Discussionmentioning

confidence: 99%

Idiopathic nodular glomerulosclerosis in a chronic marijuana user; a case report and review of the literature

Mollaee¹,

Fülöp²,

Salim³

et al. 2017

J Nephropathol

View full text Add to dashboard Cite

Idiopathic nodular glomerulosclerosis (ING) is a rare distinct clinicopathologic entity that has been linked to heavy tobacco smoking, chronic hypertension, obesity and insulin resistance. Its association with marijuana use is unknown. We report a case of biopsy-proved ING in the absence of pre-existing history of diabetic nephropathy (DN) and heavy smoking. This report addresses the possible accentuation of tobacco use risk by marijuana. Please cite this paper as: Mollaee M, Fülöp T, Abdul Salim S, Hamrahian M. Idiopathic nodular glomerulosclerosis in a chronic marijuana user; a case report and review of the literature.

show abstract

“…In the smoking-related nodular or diffuse mesangial glomerulosclerosis, the endothelial cell injuries which resemble chronic thrombotic microangiopathy characterized by endothelial swelling, subendothelial widening, new basement membrane formation and cellular interposition have been demonstrated [18,19]. Although no organized deposits are generally seen in smoking-related glomerulopathy, Salvatore et al recently found a case with focal fibrillary degeneration of the collagen matrix along the subendothelial zone out of 10 cases with smoking-related glomerulopathy [19].…”

Section: Discussionmentioning

confidence: 99%

Glomerulopathy with distinctive fibrillar deposits but lacking glomerular deposition of type III collagen

et al. 2016

View full text Add to dashboard Cite

A 62-year-old woman with nephrotic syndrome underwent a renal biopsy. Under light microscopy, the biopsy findings included lobulation and enlargement of glomeruli, occasional thickening of glomerular capillary walls, and narrowing of the capillary lumen by swollen endothelial cells. Congo red staining was negative for amyloid. No significant intraglomerular fibrin deposition was found by phosphotungstic acid hematoxylin staining. Immunofluorescence microscopy showed no deposition of immunoglobulin G, A, or M; no j or k light chains; and no C3 or C1q. Electron microscopy revealed distinctive subendothelial and mesangial fibrillar deposits, mesangial cell interposition, and swelling and vacuolization of endothelial cells resulting in capillary lumen narrowing. Although some curvilinear fibrillar deposits mimicked the bundles of type III collagen fibers seen in collagenofibrotic glomerulopathy, neither glomerular deposition of type III collagen nor elevation of serum procollagen III peptide was noted. This glomerulopathy does not fulfill any known disease entities with non-amyloid non-immunoglobulinderived organized glomerular deposits.

show abstract

Nodular Glomerulosclerosis in the Nondiabetic Smoker

Cited by 65 publications

References 28 publications

Smoking

Smoking

Idiopathic nodular glomerulosclerosis in a chronic marijuana user; a case report and review of the literature

Glomerulopathy with distinctive fibrillar deposits but lacking glomerular deposition of type III collagen

Contact Info

Product

Resources

About