2014
DOI: 10.1186/1471-2164-15-s2-p70
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Nodular goiter and hyperplastic lesion of the thyroid share common deregulated expression profiles

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Cited by 2 publications
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“…The potential regulatory roles of DLX3 and GCM1 on PGF expression may not be restricted within the placenta. For instance, GCM1 and PGF are both expressed in normal thyroid tissues, and downregulation of GCM1 and PGF has been reported in hyperplastic thyroid and malignant thyroid tumors respectively (Subhi, Baqtian, Ata, Karim, & Al‐Ghamdi, ; Viglietto et al, ), suggesting a potential stepwise connection between GCM1 and PGF dysregulation in the pathogenesis of thyroid cancer. On the other hand, DLX3 downregulation and PGF induction have been correlated in skin cancer progression, both of which have been shown to drive skin cancer cell migration and to promote wound closure (Elisabetta et al, ; Marcella et al, ; Odorisio, Cianfarani, Failla, & Zambruno, ), implying their possible involvement in common gene regulatory pathways contributing to skin cancer.…”
Section: Discussionmentioning
confidence: 99%
“…The potential regulatory roles of DLX3 and GCM1 on PGF expression may not be restricted within the placenta. For instance, GCM1 and PGF are both expressed in normal thyroid tissues, and downregulation of GCM1 and PGF has been reported in hyperplastic thyroid and malignant thyroid tumors respectively (Subhi, Baqtian, Ata, Karim, & Al‐Ghamdi, ; Viglietto et al, ), suggesting a potential stepwise connection between GCM1 and PGF dysregulation in the pathogenesis of thyroid cancer. On the other hand, DLX3 downregulation and PGF induction have been correlated in skin cancer progression, both of which have been shown to drive skin cancer cell migration and to promote wound closure (Elisabetta et al, ; Marcella et al, ; Odorisio, Cianfarani, Failla, & Zambruno, ), implying their possible involvement in common gene regulatory pathways contributing to skin cancer.…”
Section: Discussionmentioning
confidence: 99%