Nodular macroregenerative tissue as a pattern of regeneration in cholangiopathic disorders

Roberts, Preston; Trout, Andrew T.; Dillman, Jonathan R.

doi:10.1007/s00247-018-4129-5

Cited by 7 publications

(4 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…All masses (nodules) in previously described similar pediatric cases have been lesions larger than 5 cm [16]. In our case, the size of the nodule (7 × 5 cm) is compatible with that in previous reports [1,16,[18][19][20][21].…”

Section: Discussionsupporting

confidence: 92%

“…In ALGS hepatic nodules display less fibrosis and relatively well preserved interlobular bile ducts than the rest of the liver that shows either extensive fibrosis or liver cirrhosis [19]. In our case, the nodule was seen adjacent to the right portal vein, was located in the central zone of the liver, as in previous reports [1,16,[18][19][20][21], and revealed relatively well preserved interlobular bile ducts without fibrosis, whereas the rest of the liver or non-nodular lesion revealed paucity of bile ducts with stage 1 hepatic fibrosis.…”

Section: Discussionsupporting

confidence: 83%

See 1 more Smart Citation

Iron Deposit Central Large Nodule in Alagille Syndrome

Sk¹,

Fujii²,

Kobayashi³

et al. 2021

ACMCR

View full text Add to dashboard Cite

Alagille syndrome (ALGS) is a multisystem autosomal dominant disorder attributed to defects in the Notch signaling pathway. The mutation of Jagged 1 (JAG1) gene on chromosome 20 has been identified as the underlying cause of this syndrome. In addition, the mutation of Ryanodine receptor 2 (RYR2) gene on chromosome 1 has clarified. Here described is a 7 × 5 cm nodular lesion in segment 4 in a 28-year-old man with ALGS. Through imaging studies and histopathological analysis, the nodule was diagnosed, for the first time, as iron deposit giant nodule. Additionally, a review of previous reports has been made to shed more light on this syndrome.This study describes the case of a 28-year-old man with a 7 × 5 cm nodular lesion in segment 4 compatible with iron deposit central large nodule detected by radiological and histopathological analysis. We also review previous reports that describe solitary focal hepatic nodules adjacent to the right portal vein as large regenerative hyperplasia.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 83%

Iron Deposit Central Large Nodule in Alagille Syndrome

Sk¹,

Fujii²,

Kobayashi³

et al. 2021

ACMCR

View full text Add to dashboard Cite

show abstract

“…Wenzel et al [50] speculated that it contributes to periportal fibrosis or apoptosis. Giant nodular fibrosis in the central liver was similar to regenerative nodules, described as a regenerative pattern led by cholestasis [51]. Patchy fibrosis has been described in two previous case reports [11,28].…”

Section: Earlier Detection Of Liver Fibrosismentioning

confidence: 52%

Imaging Phenotypes and Evolution of Hepatic Langerhans Cell Histiocytosis on CT/MRI: A Retrospective Study of Clinical Cases and Literature Review

Hao

Xiong

et al. 2023

Bioengineering

View full text Add to dashboard Cite

(1) Background: pathological changes in hepatic Langerhans cell histiocytosis (LCH) have been observed; however, corresponding imaging findings can appear vague to physicians and radiologists. The present study aimed to comprehensively illustrate the imaging findings of hepatic LCH and to investigate the evolution of LCH-associated lesions. (2) Methods: LCH patients with liver involvement treated at our institution were retrospectively reviewed along with prior studies in PubMed. Initial and follow-up computed tomography (CT) and magnetic resonance imaging (MRI) were systematically reviewed, and three imaging phenotypes were created based on the lesion distribution pattern. Clinical features and prognoses were compared among the three phenotypes. Liver fibrosis was evaluated visually on T2-weighted imaging (T2WI) and diffusion-weighted imaging (DWI), and apparent diffusion coefficient (ADC) values of the fibrotic areas were measured. Descriptive statistics and a comparative analysis were used to analyze the data. (3) Results: based on the lesion distribution pattern on CT/MRI scans, patients with liver involvement were categorized as the disseminated lesion phenotype, scattered lesion phenotype, and central periportal lesion phenotype. Patients with scattered lesion phenotype were typically adults, and only a few of them had hepatomegaly (npresent = 1, 1/6, 16.7%) and liver biochemical abnormalities (npresent = 2, 2/6, 33.3%); patients with central periportal lesion phenotype were typically young children, and hepatomegaly and biochemical abnormalities were more apparent in these patients than those with another phenotype; and those with the disseminated lesion phenotype were found in all age groups, and the lesions evolved rapidly on medical imaging. Follow-up MRI scans show more details and can better document the evolution of lesions than CT. T2-hypointense fibrotic changes, including the periportal halo sign (npresent = 2, 2/9, 22.2%), patchy liver parenchyma changes (npresent = 6, 6/9, 66.7%), and giant hepatic nodules close to the central portal vein (npresent = 1, 1/9, 11.1%), were found, while fibrotic changes were not observed in patients with the scattered lesion phenotype. The mean ADC value for the area of liver fibrosis in each patient was lower than the optimal cutoff for significant fibrosis (METAVIR Fibrosis Stage ≥ 2) in a previous study that assessed liver fibrosis in chronic viral hepatitis. (4) Conclusions: The infiltrative lesions and liver fibrosis of hepatic LCH can be well characterized on MRI scans with DWI. The evolution of these lesions was well demonstrated on follow-up MRI scans.

show abstract

“…What's more, to our surprise, the giant nodule in the liver adjacent to the right portal venous was recognized as hepatic regenerative nodule according to imaging and pathology. Few previous literatures reported, this may be considered a benign characteristic with typical location and vessels coursing through [3,4]. Comparative analysis of pathology features between the nodule and remainder of the liver parenchyma showed less damaged liver and visible interlobular bile ducts within the mass with unknown mechanism.…”

Section: Discussionmentioning

confidence: 63%

New JAG1 Mutation and Rare Giant Hepatic Regenerate Nodule in Alagille Syndrome: A Case Report

Rao

2022

GMR

View full text Add to dashboard Cite

Nodular macroregenerative tissue as a pattern of regeneration in cholangiopathic disorders

Abstract: Central mass-like regeneration appears to be a common regenerative pattern in cholangiopathic disorders and should not be mistaken for malignancy.

Cited by 7 publications

References 11 publications

Iron Deposit Central Large Nodule in Alagille Syndrome

Iron Deposit Central Large Nodule in Alagille Syndrome

Imaging Phenotypes and Evolution of Hepatic Langerhans Cell Histiocytosis on CT/MRI: A Retrospective Study of Clinical Cases and Literature Review

New JAG1 Mutation and Rare Giant Hepatic Regenerate Nodule in Alagille Syndrome: A Case Report

Contact Info

Product

Resources

About