Nodular pulmonary ossifications in differential diagnosis of solitary pulmonary nodules

Gielis, Jan F.; Torfs, M; Luijks, Marloes; Salgado, Rodrigo; Schil, Paul E. Van

doi:10.1183/09031936.00134110

Cited by 11 publications

(12 citation statements)

References 10 publications

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“…The presence of PO does not influence patient survival when suffering from any lung disease or oncologic disease, as demonstrated through the calculated survival functions in Figure 4 . Because we found both types of PO to be present in the lungs of the same patient [ 9 ], there is probably a significant overlap between both types of PO. The nodular form, usually linked with passive congestive processes, equally appears in patients suffering from chronic obstructive pulmonary disorders in our case series, which are, in the literature, usually associated with dendriform PO.…”

Section: Discussionmentioning

confidence: 99%

Update on Pulmonary Ossifications in the Differential Diagnosis of Solitary Pulmonary Nodules

Gielis

Berzenji

Siozopoulou

et al. 2021

JCM

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Pulmonary ossifications have often been regarded as rare, post-mortem findings without any clinical significance. We have investigated the occurrence of pulmonary ossifications in patients undergoing thoracic procedures, and how this may affect the differential diagnosis of solitary pulmonary nodules. In addition, we have performed a literature search on the occurrence and possible pathogenesis of these ossifications. From January 2008 until August 2019, we identified pulmonary ossifications in 34 patients who underwent elective pulmonary surgery. Pre-operative imaging was unable to differentiate these ossifications from solid tumors. A definitive diagnosis was made by an experienced pathologist (VS, ML). The PubMed database was researched in December 2019 with the search terms “pulmonary ossifications”; “heterotopic ossifications”; and “solitary pulmonary nodule”. In total, 27 patients were male, with a mean age of 63 ± 12 years (age 41 to 82 on diagnosis). All lesions were identified on thoracic CT and marked for resection by a multidisciplinary team. A total of 17 patients were diagnosed with malignancy concurrent with ossifications. There was a clear predilection for the right lower lobe (12 cases, 35.3%) and most ossifications had a nodular form (70.6%). We could not identify a clear association with any other pathology, either cancerous or non-cancerous in origin. Oncologic or pulmonary comorbidities did not influence patient survival. Pulmonary ossifications are not as seldom as thought and are not just a curiosity finding by pathologists. These formations may be mistaken for a malignant space-occupying lesion, both pre-and perioperatively, as they are indistinguishable in imaging. We propose these ossifications as an underestimated addition to the differential diagnosis of a solitary pulmonary nodule.

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Section: Discussionmentioning

confidence: 99%

Update on Pulmonary Ossifications in the Differential Diagnosis of Solitary Pulmonary Nodules

Gielis

Berzenji

Siozopoulou

et al. 2021

JCM

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“…The pathogenesis proposed for this form is stagnation and organization of alveolar exudates and precipitation of hemosiderin on alveolar walls, resulting in nodular ossifying masses expanding into the alveolar spaces. 6 DPO is the rarest form. Lara and colleagues 3 reported a prevalence of 0.4% in their autopsy series, with a male predominance (sex ratio: 2.5) and an average age of 75 years.…”

Section: Discussionmentioning

confidence: 99%

Dendriform pulmonary ossification in a patient with mucoepidermoid carcinoma

Triki

Kallel

Abdessalem

et al. 2016

Asian Cardiovasc Thorac Ann

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Dendriform pulmonary ossification is a chronic process characterized by the presence of heterotopic bone within the interstitium and alveolar walls. It usually occurs in the setting of chronic inflammation. We report an unusual case of a 54-year-old man with a history of relapsing Hodgkin lymphoma who was diagnosed with concomitant mucoepidermoid pulmonary carcinoma and dendriform ossifications. The radiological features were initially misinterpreted as post-radiation pulmonary fibrosis and bronchiectasis. The diagnosis was finally established after considering both the radiological and pathological findings. Dendriform pulmonary ossification is an under-recognized disease that should be considered in the differential diagnosis of lung chronic diseases.

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“…DPO is typically diagnosed as an incidental finding on postmortem examination, although pneumothorax may occur due to pleural rupture. [55][56][57][58][59][60][61][62][63][64][65] Two histologic subtypes of DPO are described in humans: nodular and dendriform.…”

Section: Have a Bone To Pick: Dendriform Pulmonary Ossification And F...mentioning

confidence: 99%

“…These cases are often associated with mitral valve stenosis and other causes of chronic pulmonary congestion. 57,58 Patients with dendriform pulmonary ossification have spicules of metaplastic bone within alveolar septa which often contain bone marrow. [55][56][57][58]65 Histologic features of the presented case were most consistent with dendriform pulmonary ossification as opposed to nodular pulmonary ossification.…”

Section: Have a Bone To Pick: Dendriform Pulmonary Ossification And F...mentioning

confidence: 99%

Proceedings of the 2022 National Toxicology Program Satellite Symposium

et al. 2022

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The 2022 annual National Toxicology Program Satellite Symposium, entitled “Pathology Potpourri,” was held in Austin, Texas at the Society of Toxicologic Pathology’s 40th annual meeting during a half-day session on Sunday, June 19. The goal of this symposium was to present and discuss challenging diagnostic pathology and/or nomenclature issues. This article presents summaries of the speakers’ talks along with select images that were used by the audience for voting and discussion. Various lesions and topics covered during the symposium included induced and spontaneous neoplastic and nonneoplastic lesions in the mouse lung, spontaneous lesions in the reproductive tract of a female cynomolgus macaque, induced vascular lesions in a mouse asthma model and interesting case studies in a rhesus macaque, dog and genetically engineered mouse model.

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Nodular pulmonary ossifications in differential diagnosis of solitary pulmonary nodules

Cited by 11 publications

References 10 publications

Update on Pulmonary Ossifications in the Differential Diagnosis of Solitary Pulmonary Nodules

Update on Pulmonary Ossifications in the Differential Diagnosis of Solitary Pulmonary Nodules

Dendriform pulmonary ossification in a patient with mucoepidermoid carcinoma

Proceedings of the 2022 National Toxicology Program Satellite Symposium

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