Nodular Type and Older Age as the Most Significant Associations of Thick Melanoma in Victoria, Australia

Chamberlain, Alex J; Fritschi, Lin; Giles, Graham G.; Dowling, John P.; Kelly, John W.

doi:10.1001/archderm.138.5.609

Cited by 141 publications

(164 citation statements)

References 35 publications

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“…11,12 Previous studies found men age !50 years more commonly present with thick and nodular melanomas compared with women and younger people, and should be targeted by early detection programs. 4,[13][14][15][16][17][18] Despite this, within general practice, excisions are more commonly performed on patients age <50 years compared with patients age !50 years. 19 Older men are also less likely to self-present with a lesion of concern at open access community screening programs.…”

mentioning

confidence: 99%

What motivates men age ≥ 50 years to participate in a screening program for melanoma?

Janda

Youl

Lowe

et al. 2006

Cancer

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BACKGROUND.The screening behavior and screening outcomes of men age ≥50 years was investigated within a randomized controlled trial of a community‐based intervention of screening for melanoma, consisting of a community education program, an education program for medical practitioners, and the provision of dedicated skin‐screening clinics.METHODS.Data from cross‐sectional telephone surveys before (559 completed interviews), at the end (591 completed interview), and at 2 years after the intervention (445 completed interviews) were analyzed. In addition, the authors analyzed data from skin‐screening clinics within the intervention program (3355 men age ≥50 years participated).RESULTS.During the intervention period men age ≥50 years increased both their screening behavior and intention to screen. Those men age ≥50 years who reported a past history of removal of a mole as well as other risk factors for skin cancer and positive attitudes toward screening were more likely to participate in skin screening across time. Men age ≥50 years accounted for 20.5% of all skin‐screening clinic attendees, 31.3% of those referred for a suspicious lesion, 48.5% of melanomas, and 45% of all keratinocyte carcinomas diagnosed within the screening program, respectively.CONCLUSIONS.The intervention program successfully motivated men age ≥50 years to attend screening for skin cancer, resulting in the highest yield of skin cancer within this subgroup of the population. Messages addressing skin cancer risk factors and attitudes toward skin cancer and screening could be used to target a screening program for melanoma toward men age ≥50 years. Cancer 2006. © 2006 American Cancer Society.

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mentioning

confidence: 99%

What motivates men age ≥ 50 years to participate in a screening program for melanoma?

Janda

Youl

Lowe

et al. 2006

Cancer

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“…8,[12][13][14] Nodular melanomas tend to be thicker than other melanomas. 15 Familial risks have been shown for cutaneous melanoma, and in population-based studies the risks have been Ͼ 2.00 between first-degree relatives. 16,17 In Sweden, 2.4% of the affected offspring have had an affected parent but in Australia and the United States higher proportions have been cited.…”

mentioning

confidence: 99%

Incidence trends and familial risks in invasive and in situ cutaneous melanoma by sun‐exposed body sites

Hemminki

Zhang

Czene

2003

Intl Journal of Cancer

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We studied incidence trends, age-incidence relationships and familial risks in invasive and in situ cutaneous melanoma, based on the Swedish Family-Cancer Database of more than 10 million individuals. Offspring were 0 -66 years of age. Cancers were obtained from the Swedish Cancer Registry from years 1961-98. The study was based on 9,771 offspring and 22,888 parents with invasive melanoma and 2,446 offspring and 5,017 parents with in situ melanoma. Incidence rates increased markedly for invasive melanoma in the trunk. For in situ melanoma, trunk and head and neck were affected, and, in addition, legs for women. The maximal incidence was around age 80 years, independent of the type or site in men; in women early onset superficially spreading melanoma shifted the age for maximal incidence to about 60 years. For in situ melanoma, lentigo maligna was the main histogenetic type in the head and neck but in the trunk and legs superficially spreading melanoma was somewhat more common. Standardized incidence ratios (SIR) were calculated for familial risk at exposed and covered sites. The combined familial risks for invasive and in situ melanoma were higher at covered (SIR 3.56 from parents) than sun-exposed (1.92 from parents) sites and they agreed when familiality was defined between parents and offspring or between siblings; the sibling SIRs were 3.90 at covered and 2.53 at exposed sites. The data suggest that the higher melanoma density at exposed sites masks familial effects. Furthermore, sun exposure does not appear to reinforce the familial effect.

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“…However, the fact that these findings have also been reported in analyses of Australian-based registries lends support to our observations. 16,27 In conclusion, NM presents with aggressive histological features and at advanced stages of disease. Targeted screening of older patient populations, with an emphasis on men, is critical if melanoma mortality rates are to be impacted.…”

Section: Discussionmentioning

confidence: 92%

“…6,26 The association of older age and male sex with NM has also been documented in Australian-based registries. 16,27 Taken together, these results suggest that older male patients need to be carefully considered for secondary prevention efforts. The HARMM (History of previous melanoma, Age over 50, Regular dermatologist absent, Mole changing, Male sex) melanoma risk assessment model, an acronym derived from the American Academy of Dermatology Skin Cancer Screening Program Data from 2001 to 2005, identified both age >50 years ("A") and male sex ("M") as risk factors for melanoma development and suggests that targeted screening of this subgroup, especially those who tan poorly, may help to improve rates of melanoma detection.…”

Section: Discussionmentioning

confidence: 93%

Changes in the presentation of nodular and superficial spreading melanomas over 35 years

2009

Journal of the American Academy of Dermatology

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BACKGROUND-Nodular melanoma (NM) may be biologically aggressive compared with the more common superficial spreading melanoma (SSM), with recent data suggesting underlying genetic differences between these 2 subtypes. To better define the clinical behavior of NMs, the authors compared their clinical and histopathologic features to those of SSMs at their institution, a tertiary referral center, over 3 decades.

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Nodular Type and Older Age as the Most Significant Associations of Thick Melanoma in Victoria, Australia

Cited by 141 publications

References 35 publications

What motivates men age ≥ 50 years to participate in a screening program for melanoma?

What motivates men age ≥ 50 years to participate in a screening program for melanoma?

Incidence trends and familial risks in invasive and in situ cutaneous melanoma by sun‐exposed body sites

Changes in the presentation of nodular and superficial spreading melanomas over 35 years

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