Noise exposure and its relationship with postinfarction cardiac remodeling: implications for NLRP3 inflammasome activation

Abstract

In recent years, high-decibel noise has emerged as a causative risk factor for ischemic heart disease. Massive noise overdose is associated with increased endocrine, neural, and immune stress responses. The NLRP3 (nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain containing 3) inflammasome, the most characterized supramolecular complex and a potent mediator of inflammatory signaling, has been reported to be a marker of increased ischemic heart disease vulnerability. Our study evaluated the association of noise exposure with postinfarction cardiac remodeling and its effect on NLRP3 inflammasome activation. Rats were exposed to a noisy environment (14 days, 24 h/per day, 70 ± 5 dB), and speck formation by the NLRP3 inflammasome scaffold protein ASC (apoptosis-associated speck-like protein) was assessed by confocal immunofluorescence. Echocardiography, pathological analysis, and in vivo electrophysiology were performed. Our results revealed the improved postinfarction cardiac function, mitigated fibrosis, and decreased arrhythmia vulnerability and sympathetic sprouting in low-environment noise groups. Moreover, western blotting of NLRP3, caspase-1, ASC, IL-1β, and IL-18 and confocal microscopy of ASC speck showed that the priming and activation of NLRP3 inflammasome were higher in the NE group than in the NI group. In conclusion, our findings reveal a previously unidentified association between NLRP3 inflammasome activation and noise exposure, underscoring the significance of effective noise prevention in improving postinfarction prognosis.

An updated job-exposure matrix for occupational noise: development and validation

“…The presented JEMs have already been used in several studies ( Eriksson et al 2018 ; Enoksson Wallas et al , 2019 ; Wallas et al 2018 , 2019 , 2020 ; Aarhus et al 2020 ; Eriksson et al 2021 ; Lissaker et al 2021 ; Thacher et al 2022 ) to study health effects from noise exposure such as cortisol levels, asthma, birth outcomes, and cardiovascular disease. We anticipate further use as an increasing number of epidemiological studies has shown health effects as a result of long-term exposure to noise ( An et al 2018 ; Kerns et al 2018 ; Brauner et al 2019 ; Liu et al 2022 ; Wei et al 2022 ).…”

Muscone attenuates susceptibility to ventricular arrhythmia by inhibiting NLRP3 inflammasome activation in rats after myocardial infarction

“…In vivo programmed electrical stimulation was performed as previously described. [ 22 ] In brief, the chest of the rat was opened to expose the heart after anaesthetization. Then, a recording electrode and a stimulating electrode were used to record the monophasic action potentials (MAPs) from the basal surface of the infarcted‐BZ.…”