Noise improves the association between effects of local stimulation and structural degree of brain networks

Abstract

Stimulation to local areas remarkably affects brain activity patterns, which can be exploited to investigate neural bases of cognitive function and modify pathological brain statuses. There has been growing interest in exploring the fundamental action mechanisms of local stimulation. Nevertheless, how noise amplitude, an essential element in neural dynamics, influences stimulation-induced brain states remains unknown. Here, we systematically examine the effects of local stimulation by using a large-scale biophysical model under different combinations of noise amplitudes and stimulation sites. We demonstrate that noise amplitude nonlinearly and heterogeneously tunes the stimulation effects from both regional and network perspectives. Furthermore, by incorporating the role of the anatomical network, we show that the peak frequencies of unstimulated areas at different stimulation sites averaged across noise amplitudes are highly positively related to structural connectivity. Crucially, the association between the overall changes in functional connectivity as well as the alterations in the constraints imposed by structural connectivity with the structural degree of stimulation sites is nonmonotonically influenced by the noise amplitude, with the association increasing in specific noise amplitude ranges. Moreover, the impacts of local stimulation of cognitive systems depend on the complex interplay between the noise amplitude and average structural degree. Overall, this work provides theoretical insights into how noise amplitude and network structure jointly modulate brain dynamics during stimulation and introduces possibilities for better predicting and controlling stimulation outcomes.

Spatio-temporal Heterogeneity in the Performance of Rural Revitalization in Chifeng City of China: Based on a Range-wide EBM-GML Model

“…Since the rural revitalization strategy is proposed, rural development has received wide attention and rural revitalization has become a research hotspot [1] . The implementation of a rural revitalization strategy will definitely inject a strong impetus into the development of rural China [2] . The performance assessment of rural revitalization provides valuable guidance, a standard system and social momentum for achieving the goals of rural revitalization planning [3] .…”