Nomogram Based on Preoperative Fibrinogen and Systemic Immune-Inflammation Index Predicting Recurrence and Prognosis of Patients with Borrmann Type III Advanced Gastric Cancer

Wang, Hao; Yin, Xin; Ma, Keru; Wang, Yufei; Fang, Tianyi; Zhang, Yao; Xue, Yingwei

doi:10.2147/jir.s404585

Cited by 3 publications

References 52 publications

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Objective Evaluation of the Prognostic Value of Common Nutritional Indicators in Patients with Different Inflammatory States after Radical Gastrectomy for Gastric Cancer: A Real-world Study Running Head：Nutritional Indicators in Inflammatory State

Zheng,

Wei

et al. 2024

Preprint

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Background and aim: Few studies have investigated the prognostic significance of nutritional indicators in patients with various inflammatory states. Methods Patients who underwent radical gastrectomy for TNM stages I–III gastric cancer were included. Nutritional assessment was performed using commonly used indicators. The patients were categorized into two groups with high and low inflammatory status using the X-tile analysis. Results A total of 1327 patients were enrolled in this study, including 843 and 484 patients in the low- and high-SII groups, respectively. Compared with the SII-low group, the SII-high group exhibited significantly lower GNRI, PNI, CXI, and SMI indices and a higher proportion of patients with malnutrition based on the GLIM and CONUT criteria(all P < 0.05). Multivariate COX analysis revealed that GLIM criteria (overall survival [OS]: P = 0.002; recurrence-free survival [RFS]: P = 0.007) and CONUT (OS: P = 0.010; RFS:P = 0.001) were independent prognostic factors for OS and RFS in the SII-low group. In the SII-high group, the GLIM criteria, GNRI, and SMI were the independent prognostic factors for OS(all P < 0.05), the GLIM criteria and SMI were the independent influencing factors for RFS(all P < 0.05). The TimeROC curve and AUC demonstrated the robustness of the GLIM criteria in predicting prognosis across various inflammatory states. Conclusions Different nutritional indicators should be considered while evaluating the prognosis of patients with gastric cancer with varying inflammatory states. Compared with other nutritional indicators, the GLIM criteria are more suitable for patients with different inflammatory conditions.

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Objective Evaluation of the Prognostic Value of Common Nutritional Indicators in Patients with Different Inflammatory States after Radical Gastrectomy for Gastric Cancer: A Real-world Study Running Head：Nutritional Indicators in Inflammatory State

Zheng,

Wei

et al. 2024

Preprint

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Fibrinogen and tumors

Wu,

Yu,

Chen

et al. 2024

Front. Oncol.

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Elevated plasma fibrinogen (Fg) levels consistently correlate with an unfavorable prognosis in various tumor patient cohorts. Within the tumor microenvironment, aberrant deposition and expression of Fg have been consistently observed, interacting with multiple cellular receptors and thereby accentuating its role as a regulator of inflammatory processes. Specifically, Fg serves to stimulate and recruit immune cells and pro-inflammatory cytokines, thereby contributing to the promotion of tumor progression. Additionally, Fg and its fragments exhibit dichotomous effects on tumor angiogenesis. Notably, Fg also facilitates tumor migration through both platelet-dependent and platelet-independent mechanisms. Recent studies have illuminated several tumor-related signaling pathways influenced by Fg. This review provides a comprehensive summary of the intricate involvement of Fg in tumor biology, elucidating its multifaceted role and the underlying mechanisms.

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Systemic immune inflammation index and gastric cancer prognosis: A systematic review and meta‑analysis

Yang,

2024

Exp Ther Med

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The present study aimed to pool the available data on the associations between the systemic immune inflammation index (SII) and overall survival (OS) or recurrence-free survival (RFS) in patients with gastric cancer (GC). A systematic search was conducted in the PubMed, EMBASE and Scopus databases for observational studies, and a random effects model was used to conduct the statistical analysis. Pooled effect sizes were reported as hazard ratios (HRs) with corresponding 95% confidence intervals (CI). Data from 30 studies (24 conducted in China) with follow-ups ranging between 15.5 and 65.6 months were analyzed. Patients with GC and high SII levels had poor OS (HR, 1.53; 95% CI, 1.34-1.75) and recurrence free survival (HR, 1.41; 95% CI, 1.17-1.70). These increased risks were present irrespective of the treatment strategy (surgical or non-surgical management), the sample size (<500 and ≥500) and the cut-off used to define high and low SII (<600 and ≥600 x10 9 cells/l). The results of this meta-analysis suggest that high pretreatment SII levels were associated with poor OS and RFS in patients with GC.

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Nomogram Based on Preoperative Fibrinogen and Systemic Immune-Inflammation Index Predicting Recurrence and Prognosis of Patients with Borrmann Type III Advanced Gastric Cancer

Cited by 3 publications

References 52 publications

Objective Evaluation of the Prognostic Value of Common Nutritional Indicators in Patients with Different Inflammatory States after Radical Gastrectomy for Gastric Cancer: A Real-world Study Running Head：Nutritional Indicators in Inflammatory State

Objective Evaluation of the Prognostic Value of Common Nutritional Indicators in Patients with Different Inflammatory States after Radical Gastrectomy for Gastric Cancer: A Real-world Study Running Head：Nutritional Indicators in Inflammatory State

Fibrinogen and tumors

Systemic immune inflammation index and gastric cancer prognosis: A systematic review and meta‑analysis

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