Nomogram Predicting Overall Survival in Operable Cervical Cancer Patients

Zheng, Ren; Huang, Xiaowan; Liu, Wen-Yue; Lin, Ronggui; Zheng, Fangfang; Lin, Feng

doi:10.1097/igc.0000000000000987

Cited by 17 publications

(13 citation statements)

References 43 publications

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“…Alb is closely related to nutritional status in patients, which is a good indicator of immune status. Zheng found that hypoalbuminemia was associated with poor survival in 798 patients with early-stage cervical cancer [31], which was also observed in our study. Additionally, the SIS was also significantly influenced by prognosis when stratified by FIGO stage.…”

Section: Discussionsupporting

confidence: 89%

Systemic Inflammatory Score predicts Overall Survival in patients with Cervical Cancer

Xu¹,

Wu²,

Cai³

et al. 2021

J. Cancer

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Background: To evaluate the prognostic value of the systemic inflammatory score (SIS) in cervical cancer patients. Methods: A total of 264 patients with FIGO stage (2009) IB-IIA cervical cancer undergoing radical resection from January 2014 to December 2017 were recruited. The optimal cutoff values for inflammatory biomarkers were calculated by X-tile software. The prognostic factors were investigated using univariate and multivariate Cox analyses. Time-dependent receiver operating characteristic (time-ROC) analysis and the concordance index (C-index) were used to compare the prognostic impact of factors. Results: In total, 264 patients with cervical cancer were included in the study. The optimal cutoff value for lymphocyte-to-monocyte ratio (LMR) was 4.1. In multivariate analysis, FIGO stage, lymphovascular invasion, lymph node metastasis, preoperative serum albumin (Alb), and LMR were independent prognostic factors (P<0.05). Then, we combined preoperative Alb and LMR to establish the SIS. Multivariate analysis showed that the SIS was an independent factor that affected survival (P<0.05). When stratified by FIGO stage, significant differences in survival were also found for patients with different SISs (P<0.05). When the SIS and FIGO stage were combined, the time-ROC curve was superior to that of FIGO stage only. The C-index of the model combining the SIS and FIGO stage was 0.786 (95% CI 0.699-0.873), which was significantly higher than that of the model with FIGO stage only (0.676, 95% CI 0.570-0.782, P=0.0049). Conclusions:The preoperative SIS is a simple and useful prognostic factor for postoperative survival in patients with cervical cancer. It might assist in the identification of high-risk patients among patients with the same FIGO stage.

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Section: Discussionsupporting

confidence: 89%

Systemic Inflammatory Score predicts Overall Survival in patients with Cervical Cancer

Xu¹,

Wu²,

Cai³

et al. 2021

J. Cancer

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show abstract

“…Alb is closely related to nutritional status in patients, which is a good indicator of immune status. Zheng found that hypoalbuminemia was associated with poor survival in 798 patients with early-stage cervical cancer [29], which was also observed in our study. Additionally, the SIS was also signi cantly in uenced by prognosis when strati ed by FIGO stage.…”

Section: Discussionsupporting

confidence: 89%

Systemic Inflammatory Score Predicts Overall Survival In Patients With Cervical Cancer

Cai

et al. 2020

Preprint

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Background To evaluate the prognostic value of the systemic inflammatory score (SIS) in cervical cancer patients.Methods The optimal cutoff values for inflammatory biomarkers were calculated by X-tile software. The prognostic factors were investigated using univariate and multivariate Cox analyses. Time-dependent receiver operating characteristic (time-ROC) analysis and the concordance index (C-index) were used to compare the prognostic impact of factors. Results In total, 264 patients with cervical cancer were included in the study. The optimal cutoff value for lymphocyte-to-monocyte ratio (LMR) was 4.1. In multivariate analysis, FIGO stage, lymphovascular invasion, lymph node metastasis, preoperative serum albumin (Alb), and LMR were independent prognostic factors (P<0.05). Then, we combined preoperative Alb and LMR to establish the SIS. Multivariate analysis showed that the SIS was an independent factor that affected survival (P<0.05). When stratified by FIGO stage, significant differences in survival were also found for patients with different SISs (P<0.05). When the SIS and FIGO stage were combined, the time-ROC curve was superior to that of FIGO stage only. The C-index of the model combining the SIS and FIGO stage was 0.786 (95% CI 0.699-0.873), which was significantly higher than that of the model with FIGO stage only (0.676, 95% CI 0.570-0.782, P=0.0049).Conclusions The preoperative SIS is a simple and useful prognostic factor for postoperative survival in patients with cervical cancer. It might assist in the identification of high-risk patients among patients with the same FIGO stage.

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“…A 3 éves túlélés a mGPS 0., 1. és 2. csoportjában 92%, 71% és 72% (p = 0,0035) volt [30]. Reszekábilis méhnyakrákban (n = 795) a szérumalbuminszint (más faktorok mellett, mint a BMI, vérlemezkeszám, fehérvérsejtszám, a daganat differenciáltsági foka és a kismedencei nyirokcsomóstatus) az OS független prognosztikai faktorának bizonyult (p<0,05) [31]. Epithelialis ovarium carcinoma (n = 213) minden stádiumában rosszabb túlélés társult (p<0,001) az alacsony albuminszinttel (≤35 g/l) [32] -ezt a tényt más szerzők korábban már prognosztikai modellekkel is leírták [33].…”

Section: Eredményekunclassified

“…A szerzők javasolták, hogy a műtét utáni albuminszint normális tartományban tartásához (≥35 g/l) a preoperatíve mért <45 g/l albuminszint esetén táplálásterápia bevezetését tartották szükségesnek [71]. Figyelemre méltó, hogy lokalizált rosszindulatú daganatos betegségekben a normális BMI-érték melletti alacsony albuminszint rossz prognózist vetít előre, míg a BMI-értéknek az esetek nagyobb részében nincs prognosztikus értéke [25,31,32,34,37]. Gyomorrákban (n = 830) a kemoterápiás kezelés alatt alkalmazott táplá-lásterápia azoknál a pácienseknél jelentett túlélési előnyt, akiknél a kiindulási tápláltsági kockázatszűrés (NRS) pontszáma <3 volt (átlagos túlélés 31,9 vs. 25,7 hó; p<0,001).…”

Section: öSszefoglaló Közleményunclassified

Az albumin prognosztikai jelentősége az onkológiában

Deme¹,

Telekes

2018

Orvosi Hetilap

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A szérumalbuminszint csökkenése figyelhető meg gyulladásos folyamatokban. A helyileg előrehaladott vagy áttétes rosszindulatú daganatokban a szérumalbuminszint ugyancsak csökken, az alultápláltság fennállásától függetlenül. A csökkent albuminszint befolyásolhatja a terápia eredményeit is (például gyógyszerek farmakokinetikája, mellékha-tások mértéke). Kiterjedt szakirodalmi adat és gyakorlati tapasztalat bizonyítja a táplálásterápiában részesülő pácien-sek jobb prognózisát. A szerzők a fontosabb szakirodalmi adatok alapján összefoglalják azon vizsgálatokat, melyek a kiindulási szérumalbuminszint és a rosszindulatú daganatos betegségek prognózisa közötti szoros összefüggést feltárták. Orv Hetil. 2018; 159(3): 96-106. Kulcsszavak: albumin, rosszindulatú daganatok, prognózis Prognostic importance of albumin in oncologyDiminished serum albumin level can be observed in inflammatory processes. Serum albumin level also reduces -irrespective of the presence of malnutrition -in locally advanced or metastatic malignancies. Low serum albumin level may have an influence also on the results of anticancer therapy (e.g., drug pharmacokinetics, adverse drug reactions). Extensive data of the literature and empirical experience prove the better prognosis of patients involved in nutritional therapy. Based on the most relevent data of the literature, the authors summarize the studies which have revealed the close correlation between the baseline serum albumin level and the prognosis of malignant diseases. Rövidítések ALI = (advanced lung cancer inflammation index) előrehala-dott tüdőrák index; APACHE = (acute physiology and chronic health evaluation) heveny élettani és idült egészség értékelés; BC = (breast cancer) emlőrák; BMI = (body mass index) testtömegindex (kg/m 2 ); CI = konfidenciaintervallum; CRC = (colorectal cancer) vastag-és végbélrák; CRP = C-reaktív protein; CRPC = (castration-resistant prostate cancer) kasztráció-rezisztens prostatarák; CSS = (cancer specific survival) daganatspecifikus túlélés; DFS = (disease-free survival) betegségmentes túlélés; DNS = dezoxiribonukleinsav; DSS = (disease-specific survival) betegségspecifikus túlélés; GPS = (Glasgow Prognostic Score) Glasgow prognosztikai pontrendszer; HCC = (hepatocellular carcinoma) primer májrák; HR = (hazard ratio) kockázati hányados; IL = interleukin; IMA = ischaemiamódosított albumin; IPI = (inflammatory prognostic index) gyulladásos prognosztikai index; KPS = Karnofsky Performance Status; LDH = (lactate dehydrogenase) laktátdehidrogenáz; LMR = (lymphocyte-monocyte ratio) abszolút lymphocyta-monocyta arány; mGPS = (modified Glasgow Prognostic Score) módosí-tott Glasgow prognosztikai pontrendszer; mGPS 0, 1, 2 = a módosított Glasgow prognosztikai pontrendszer értékei 0, 1, 2; MSKCC = Memorial Sloan Kettering Cancer Center; nabpaclitaxel = nanopartikuláris albuminhoz kötött paclitaxel; NLR = (neutrophil-lymphocyte ratio) abszolút neutrophillym phocyta arány; NRS = (nutritional risk screening) tápláltsá-gi kockázatszűrés; NSCLC = (non-small cell lung cancer) nem...

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Nomogram Predicting Overall Survival in Operable Cervical Cancer Patients

Abstract: We developed a novel nomogram that can provide prediction of OS for patients with early stage cervical cancer individually. Furthermore, studies are required to validate whether it can be applied to other cohorts.

Cited by 17 publications

References 43 publications

Systemic Inflammatory Score predicts Overall Survival in patients with Cervical Cancer

Systemic Inflammatory Score predicts Overall Survival in patients with Cervical Cancer

Systemic Inflammatory Score Predicts Overall Survival In Patients With Cervical Cancer

Az albumin prognosztikai jelentősége az onkológiában

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