Nomograms Predict Overall Survival and Cancer-Specific Survival in Patients with Fibrosarcoma: A SEER-Based Study

Abstract

Purpose. Due to the rarity, it is difficult to predict the survival of patients with fibrosarcoma. This study aimed to apply a nomogram to predict survival outcomes in patients with fibrosarcoma. Methods. A total of 2235 patients with diagnoses of fibrosarcoma were registered in the Surveillance, Epidemiology, and End Results database, of whom 663 patients were eventually enrolled. Univariate and multivariate Cox analyses were used to identify independent prognostic factors. Nomograms were constructed to predict 3-year and 5‐year overall survival and cancer‐specific survival of patients with fibrosarcoma. Results. In univariate and multivariate analyses of OS, age, sex, race, tumor stage, pathologic grade, use of surgery, and tumor size were identified as independent prognostic factors. Age, sex, tumor stage, pathologic grade, use of surgery, and tumor size were significantly associated with CSS. These characteristics were further included to establish the nomogram for predicting 3-year and 5-year OS and CSS. For the internal validation of the nomogram predictions of OS and CSS, the C-indices were 0.784 and 0.801. Conclusion. We developed the nomograms that estimated 3-year and 5-year OS and CSS. These nomograms not only have good discrimination performance and calibration but also provide patients with better clinical benefits.

Primary Site and Other Prognostic Factors for Fibrosarcoma: An Analysis of the National Cancer Database

“…Many of the descriptive statistics for our patient cohort provide support for the previously reported characteristics of patients diagnosed with FS. We found that FS is slightly more common in males than females, which is consistent with other sources that report a very slight male predominance [ 3 , 12 , 13 ], although an equal sex incidence has also been reported [ 1 , 13 ]. If there is a true difference in sex incidence, it is likely minimal.…”

“…However, due to the rarity of cases, factors affecting the overall survival of FS have not been comprehensively studied. Male sex, older age, advanced stage, higher grade, increased tumor size, and not receiving surgical treatment have been reported to be associated with decreased overall survival [ 13 ]. The goal of our study is to further assess prognostic variables for FS.…”

A Clinical Nomogram for Predicting Cancer-Specific Survival in Pulmonary Large-Cell Neuroendocrine Carcinoma Patients: A Population-Based Study

“…One of the most widely available prediction tools is nomogram, a visualizing survival prediction model. [7][8][9][10] Recent studies have developed a nomogram to predict the overall survival (OS) for LCNEC. 11 However, as far as we are aware, nomograms for predicting the CSS of patients with LCNEC have not been reported.…”

Prognostic Nomogram and a Risk Classification System for Predicting Overall Survival of Elderly Patients with Fibrosarcoma: A Population-Based Study

“…e prognostic factors associated with OS and cancerspecific survival in fibrosarcoma have been reported in previous studies [26]. However, the study included patients of all ages, which makes it questionable whether the results of the study are fully applicable to older patients with fibrosarcoma.…”

“…Even in this particular group of elderly patients, there is a tendency for the prognosis to deteriorate with age. First of all, it is probably since older patients are usually more likely to suffer from chronic diseases or postoperative complications, making them more likely to die [ 26 ]. Secondly, as older patients are generally in worse health, surgeons may hesitate to treat older patients as intensively and aggressively as younger patients, leaving older patients undertreated [ 29 , 30 ].…”