Non-absorbable mesoporous silica for the development of protein sequestration therapies

Mesoporous Silica with Precisely Controlled Pores Reduces Food Efficiency and Suppresses Weight Gain in Mice

“…Based on our previous work, we hypothesize that all MSP with pore sizes of approximately 10 nm [48] would have effects in a DIO mouse model. However, this was not the case since only two out of four particles tested-induced effect.…”

Influence of a Protein Corona on the Oral Pharmacokinetics of Testosterone Released from Mesoporous Silica

“…The 3D pore structure and connectivity of the ASM‐6 mesopores are likely responsible for this effect, both from the perspective of pore accessibility as well as reduced wall–drug interactions. In the context of gastrointestinal retention times, this release is too fast as between 60% and 85% of the drug releases in the first 6 h in SIF . It is important to note that no additional excipient was included in the formulation and that the particles were not compressed into tablets.…”

“…Thus, the formation of a new gastrointestinal enzymatic corona around the particles is likely. A negatively charged particle will dominate the silica surface in accordance to its isoelectric point of 3.4, but this will be reversed in the stomach where the acidic gastric secretions with pH values as low as 0.7 will result in the net particle charge being positive and a rearrangement or formation of a new protein/enzyme corona . As the particles emerge from the stomach they will be rapidly neutralized by pancreatic secretions, which again may cause a change in the enzymatic corona governed presumably by pancreatic enzymes.…”