2010
DOI: 10.1039/b922101h
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Non-classical anticancer agents: synthesis and biological evaluation of zinc(ii) heteroleptic complexes

Abstract: New heteroleptic complexes (1-8) containing Zn(II) ion coordinated to an N,N-chelating ligand (the 4,4'-dinonyl-2,2'-bipyridine, bpy-9) and to diketonates L such as tropoloids (Tropolone and Hinokitiol) or 1-phenyl-3-methyl-4-R-5-pyrazolones have been synthesized by using different stoichiometric ratio with respect to the L ancillary ligand. The molecular structure of the bis-tropolonate derivative [(bpy-9)Zn(L)(2)] 5 has been determined by single-crystal X-ray diffraction. The antitumour activity of all Zn(II… Show more

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Cited by 87 publications
(55 citation statements)
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“…[35][36][37][38][39][40][41][42] In this perspective, iminopyridyl based zinc(II) complexes were found to be involved in targeting and modulating amyloid-β (Aβ) species which could serve as suitable chemical tools for investigating metal-Aβ-associated events in AD. 41 Furthermore, the use of Zn(II) species as antitumour drugs is very intriguing with respect to existing antitumour therapies; 43 Zn ions are preferred by hydrolytic enzymes due to its redox inertness, low toxicity, hard Lewis acid properties and bioavailability. Hence, efficient Zn(II)-based hydrolytic cleavage agents are good candidates for biomedical applications.…”
Section: Introductionmentioning
confidence: 99%
“…[35][36][37][38][39][40][41][42] In this perspective, iminopyridyl based zinc(II) complexes were found to be involved in targeting and modulating amyloid-β (Aβ) species which could serve as suitable chemical tools for investigating metal-Aβ-associated events in AD. 41 Furthermore, the use of Zn(II) species as antitumour drugs is very intriguing with respect to existing antitumour therapies; 43 Zn ions are preferred by hydrolytic enzymes due to its redox inertness, low toxicity, hard Lewis acid properties and bioavailability. Hence, efficient Zn(II)-based hydrolytic cleavage agents are good candidates for biomedical applications.…”
Section: Introductionmentioning
confidence: 99%
“…The organic compounds L 1 -L 5 (see Scheme 1) were synthesized according to a previously published procedure [18,20]. The identity and purity of the organic compounds L 1 -L 5 were proved by elemental analysis (C, H, N), and FT-IR, 1 H and 13 C NMR spectroscopies (see Supplementary material).…”
Section: Starting Materialsmentioning
confidence: 99%
“…This knowledge has led to the search for new zinc supplementary strategies involving the prevention and inhibition of prostate cancer, and also looking for new potentially anticancer active drugs based on zinc coordination compounds. Indeed, very interesting results of in vitro cytotoxicity were found for the zinc(II) complexes with the general formulae [Zn(bpy-9)(L) 2 ] and [Zn(bpy-9)(L)Cl(Solv)] (where bpy-9 = the N,N-chelating ligand 4,4 0 -dinonyl-2,2 0 -bipyridine and L stands for O,O-ligands such as Tropolone (Trop) and Hinokitiol, or 1-phenyl-3-methyl-4-R-5-pyrazolones), which were tested against the hormone-resistant DU145, hormone-sensitive LNCaP and PC3 prostate cancer cell lines [13]. Moreover, interesting cytotoxicity of the zinc(II) complexes involving N-donor-ligands, such as clotrimazole (clotri), was also reported [14].…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, to develop platinum-free anticancer complexes represents a subject of immediate interest for researchers in the field of non-classical anticancer agents [5,7]. One example is the Zn(II) complexes which proved to be potential anticancer agents with low in vivo toxicity and perhaps new action modes and cellular targets in contrast to the classical metallodrugs [8][9][10].…”
Section: Introductionmentioning
confidence: 99%