Non-coding RNA in cancer

Yan, Huiwen; Bu, Pengcheng

doi:10.1042/ebc20200032

Cited by 340 publications

(198 citation statements)

References 165 publications

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“…The entire mammalian genome can be transcribed to some level, yet there remain thousands of RNA transcripts that do not code for proteins. These are known as non-coding RNAs (ncRNAs) ( Palazzo and Lee, 2015 ; Yan and Bu, 2021 ; Yang et al, 2020 ; van Bakel et al, 2010 ). Their expression level and the function are very controversial.…”

Section: Epigenetic Control Of Gene Expressionmentioning

confidence: 99%

“…Based on their size, shape and genomic location, ncRNAs are divided into three major classes, long ncRNAs (lncRNAs), circular RNAs (circRNAs) and short ncRNAs (micro RNAs, short interfering RNAs, piwi RNAs) ( Palazzo and Lee, 2015 ; Wu et al, 2019 ; Yan and Bu, 2021 ). Long ncRNAs (lncRNA) are the linear gene transcripts with limited protein-coding capacities, over 200 NT long and regulate gene expression at pre-transcriptional, transcriptional, and post-transcriptional levels ( Yan and Bu, 2021 ). Depending on their expression pattern and biological function, lncRNAs can be classified as sense, antisense, bidirectional, intron, intergenic, or enhancer-lncRNAs ( Al-Rugeebah et al, 2019 ; Palazzo and Lee, 2015 ).…”

Section: Epigenetic Control Of Gene Expressionmentioning

confidence: 99%

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Navigating the genomic instability mine field of osteosarcoma to better understand implications of non-coding RNAs

Fatema¹,

Larson²,

Barrott³

2022

Biocell

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Osteosarcoma is one of the most genomically complex cancers and as result, it has been difficult to assign genomic aberrations that contribute to disease progression and patient outcome consistently across samples. One potential source for correlating osteosarcoma and genomic biomarkers is within the non-coding regions of RNA that are differentially expressed. However, it is unsurprising that a cancer classification that is fraught with genomic instability is likely to have numerous studies correlating non-coding RNA expression and function have been published on the subject. This review undertakes the formidable task of evaluating the published literature of noncoding RNAs in osteosarcoma. This is not the first review on this topic and will certainly not be the last. The review is organized with an introduction into osteosarcoma and the epigenetic control of gene expression before reviewing the molecular function and expression of long non-coding RNAs, circular RNAs, and short non-coding RNAs such as microRNAs, piwi RNAs, and short-interfering RNAs. The review concludes with a review of the literature and how the biology of non-coding RNAs can be used therapeutically to treat cancers, especially osteosarcoma. We conclude that non-coding RNA expression and function in osteosarcoma is equally complex to understanding the expression differences and function of coding RNA and proteins; however, with the added lens of both coding and non-coding genomic sequence, researchers can begin to identify the patterns that consistently associate with aggressive osteosarcoma.

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Section: Epigenetic Control Of Gene Expressionmentioning

confidence: 99%

Section: Epigenetic Control Of Gene Expressionmentioning

confidence: 99%

Navigating the genomic instability mine field of osteosarcoma to better understand implications of non-coding RNAs

Fatema¹,

Larson²,

Barrott³

2022

Biocell

View full text Add to dashboard Cite

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“…Most circRNAs generated by reverse splicing are found mainly in the cytoplasm, and translation of linear mRNAs usually requires the structure of a 5′ end cap and a 3′ end poly(A) tail to remain stable. CircRNAs are not normally considered to have a translational function ( Marquez-Molins et al, 2021 ; Yan and Bu, 2021 ) but they can initiate translation in the cell if they have an internal ribosome entry site (IRES) ( He L. et al, 2021 ; Wang et al, 2021b ; Sinha et al, 2021 ). This approach provides more polypeptide sequences and increases the polypeptide yield because the ribosome does not need to bind to RNA template repeats ( Li P. et al, 2021 ).…”

Section: Acts As a Competitive Endogenous Rnamentioning

confidence: 99%

Emerging Role and Mechanism of circRNAs in Pediatric Malignant Solid Tumors

Shen

Liu

et al. 2022

Front. Genet.

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Circular RNAs (circRNAs) are non-coding RNAs with covalent closed-loop structures and are widely distributed in eukaryotes, conserved and stable as well as tissue-specific. Malignant solid tumors pose a serious health risk to children and are one of the leading causes of pediatric mortality. Studies have shown that circRNAs play an important regulatory role in the development of childhood malignant solid tumors, hence are potential biomarkers and therapeutic targets for tumors. This paper reviews the biological characteristics and functions of circRNAs as well as the research progress related to childhood malignant solid tumors.

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“…Recent findings have highlighted that noncoding RNAs expression is systematically altered in cancers (Vo et al, 2019; Yan & Bu, 2021), interpreting the essential role of noncoding RNAs on tumorigenesis, growth, invasion, and progression. Among them, miRNA, lncRNA, and circRNA are the three major ncRNA subtypes with distinct functions in Human malignancies.…”

Section: Comparisons Limitations Future Perspectives and Conclusionmentioning

confidence: 99%

Regulation of cancer progression by circRNA and functional proteins

Chen

Tang

et al. 2021

Journal Cellular Physiology

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Circular RNAs (circRNAs) are closed back‐splicing products of precursor mRNA in eukaryotes. Compared with linear mRNAs, circRNAs have a special structure and stable expression. A large number of studies have provided different regulatory mechanisms of circRNAs in tumors. Challenges exist in understanding the control of circRNAs because of their sequence overlap with linear mRNA. Here, we survey the most recent progress regarding the regulation of circRNA biogenesis by RNA‐binding proteins, one of the vital functional proteins. Furthermore, substantial circRNAs exert compelling biological roles by acting as protein sponges, by being translated themselves or regulating posttranslational modifications of proteins. This review will help further explore more types of functional proteins that interact with circRNA in cancer and reveal other unknown mechanisms of circRNA regulation.

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Non-coding RNA in cancer

Cited by 340 publications

References 165 publications

Navigating the genomic instability mine field of osteosarcoma to better understand implications of non-coding RNAs

Navigating the genomic instability mine field of osteosarcoma to better understand implications of non-coding RNAs

Emerging Role and Mechanism of circRNAs in Pediatric Malignant Solid Tumors

Regulation of cancer progression by circRNA and functional proteins

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