Non-Coding RNA Networks in Pulmonary Hypertension

Zang, Hongbin; Zhang, Qiongyu; Li, Xiaodong

doi:10.3389/fgene.2021.703860

Cited by 10 publications

(9 citation statements)

References 158 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Transcript regulation in this manner has broad potential for cancer treatment by modulating the expression of therapeutic targets in a tunable and temporally restricted manner that does not rely on the development of small molecule ligands. This technology could equally be applied in the treatment of rare genetic diseases to control the production of toxic proteins as in Huntington’s Disease, or in modulating any other RNA-mediated process including (but not limited to) hypertension, pain, and cell–cell communication [ 239 , 240 , 241 ]. The fusion of Cas7-11 to ADAR2 has already been used for efficient base editing in mammalian cells, suggesting additional applications in the treatment of genetic diseases caused by discrete heritable mutations [ 16 ].…”

Section: Emerging Applications Of Crispr-cas In Rna Editingmentioning

confidence: 99%

CRISPR-Cas System: The Current and Emerging Translational Landscape

Bhokisham

Laudermilch

Traeger

et al. 2023

Cells

View full text Add to dashboard Cite

CRISPR-Cas technology has rapidly changed life science research and human medicine. The ability to add, remove, or edit human DNA sequences has transformative potential for treating congenital and acquired human diseases. The timely maturation of the cell and gene therapy ecosystem and its seamless integration with CRISPR-Cas technologies has enabled the development of therapies that could potentially cure not only monogenic diseases such as sickle cell anemia and muscular dystrophy, but also complex heterogenous diseases such as cancer and diabetes. Here, we review the current landscape of clinical trials involving the use of various CRISPR-Cas systems as therapeutics for human diseases, discuss challenges, and explore new CRISPR-Cas-based tools such as base editing, prime editing, CRISPR-based transcriptional regulation, CRISPR-based epigenome editing, and RNA editing, each promising new functionality and broadening therapeutic potential. Finally, we discuss how the CRISPR-Cas system is being used to understand the biology of human diseases through the generation of large animal disease models used for preclinical testing of emerging therapeutics.

show abstract

Section: Emerging Applications Of Crispr-cas In Rna Editingmentioning

confidence: 99%

CRISPR-Cas System: The Current and Emerging Translational Landscape

Bhokisham

Laudermilch

Traeger

et al. 2023

Cells

View full text Add to dashboard Cite

show abstract

“…miRs are small noncoding RNAs, approximately 21-23 nucleotides in length, that repress the expression of targeted genes by binding to the 3′ untranslated region of the target gene [ 70 ]. In addition, many studies have found that miRNA is related to VSMC proliferation and vascular remodeling [ 71 ]. Here are some examples of which miRNA are involved in vascular remodeling.…”

Section: Effect Of Micrornas On Vsmcsmentioning

confidence: 99%

Mechanism of Hypoxia‐Mediated Smooth Muscle Cell Proliferation Leading to Vascular Remodeling

Huang

Akgün

Mehmood

et al. 2022

BioMed Research International

View full text Add to dashboard Cite

Vascular remodeling refers to changes in the size, contraction, distribution, and flow rate of blood vessels and even changes in vascular function. Vascular remodeling can cause cardiovascular and cerebrovascular diseases. It can also lead to other systemic diseases, such as pulmonary hypertension, pulmonary atherosclerosis, chronic obstructive pulmonary disease, stroke, and ascites of broilers. Hypoxia is one of the main causes of vascular remodeling. Prolonged hypoxia or intermittent hypoxia can lead to loss of lung ventilation, causing respiratory depression, irregular respiratory rhythms, and central respiratory failure. Animals that are unable to adapt to the highland environment are also prone to sustained constriction of the small pulmonary arteries, increased resistance to pulmonary circulation, and impaired blood circulation, leading to pulmonary hypertension and right heart failure if they live in a highland environment for long periods of time. However, limited studies have been found on the relationship between hypoxia and vascular remodeling. Therefore, this review will explore the relationship between hypoxia and vascular remodeling from the aspects of endoplasmic reticulum stress, mitochondrial dysfunction, abnormal calcium channel, disordered cellular metabolism, abnormal expression of miRNA, and other factors. This will help to understand the detailed mechanism of hypoxia-mediated smooth muscle cell proliferation and vascular remodeling for the better treatment and management of diseases due to vascular remodeling.

show abstract

“…Aside from miRNAs, lncRNAs and circRNAs are other two major groups of ncRNAs relatively less investigated and understood in the PH field. However, they are attracting growing attention due to their abundance, regulatory functional roles, cell/tissue expression specificity in human diseases, and potential therapeutic targets and disease biomarkers [ 18 , 19 , 20 , 21 ]. This review focuses on the recent developments of lncRNA and circRNA related to PH.…”

Section: The Noncoding Rna Transcriptome In Pulmonary Hypertensionmentioning

confidence: 99%

The Landscape of Noncoding RNA in Pulmonary Hypertension

et al. 2022

View full text Add to dashboard Cite

The transcriptome of pulmonary hypertension (PH) is complex and highly genetically heterogeneous, with noncoding RNA transcripts playing crucial roles. The majority of RNAs in the noncoding transcriptome are long noncoding RNAs (lncRNAs) with less circular RNAs (circRNAs), which are two characteristics gaining increasing attention in the forefront of RNA research field. These noncoding transcripts (especially lncRNAs and circRNAs) exert important regulatory functions in PH and emerge as potential disease biomarkers and therapeutic targets. Recent technological advancements have established great momentum for discovery and functional characterization of ncRNAs, which include broad transcriptome sequencing such as bulk RNA-sequence, single-cell and spatial transcriptomics, and RNA-protein/RNA interactions. In this review, we summarize the current research on the classification, biogenesis, and the biological functions and molecular mechanisms of these noncoding RNAs (ncRNAs) involved in the pulmonary vascular remodeling in PH. Furthermore, we highlight the utility and challenges of using these ncRNAs as biomarkers and therapeutics in PH.

show abstract

Non-Coding RNA Networks in Pulmonary Hypertension

Cited by 10 publications

References 158 publications

CRISPR-Cas System: The Current and Emerging Translational Landscape

CRISPR-Cas System: The Current and Emerging Translational Landscape

Mechanism of Hypoxia‐Mediated Smooth Muscle Cell Proliferation Leading to Vascular Remodeling

The Landscape of Noncoding RNA in Pulmonary Hypertension

Contact Info

Product

Resources

About