Non-Coding RNA Regulatory Network in Ischemic Stroke

Abstract

Stroke is a worldwide public health problem that has caused a substantial economic burden to families and society. Despite recent major advances, there is still a need for more timely, effective diagnosis and treatment methods for acute ischemic stroke. Non-coding RNAs (ncRNAs), which widely exist in the human body, do not encode proteins. Instead, these mediate various cellular processes as functional regulatory molecules from the RNA level. Each ncRNA node in organisms is not isolated but constitutes a complex regulatory network, regulating multiple molecular targets and triggering specific physiological or pathological reactions, leading to different outcomes. Abundant studies have proclaimed the impact of ncRNAs in ischemic stroke, which may enlighten new inspirations for diagnosing and treating ischemic stroke. This paper outlines the current understanding of the ncRNA regulatory network and reviews the recent evidence for the contribution of ncRNAs in the experimental ischemic stroke model.

Identification of five characteristic ferroptosis-related genes as novel biomarkers for ischemic stroke using bioinformatic and machine learning strategies

“…Our study also focused on non-coding RNAs associated with these critical genes. Previous studies have shown that non-coding RNAs play an essential regulatory role in IS through various pathways, such as apoptosis, oxidative stress, activation of microglia, and regeneration of vascular endothelial cells [43]. As an important regulatory factor of IS, miRNA is involved in the occurrence and regulation of ischemic nerve tissue inflammation and has potential application value for the neuroprotection and neovascularization of IS [24].…”