Non-Coding RNA Related to MAPK Signaling Pathway in Liver Cancer

Wang, Qiuxia; Feng, Jianguo; Tang, Liling

doi:10.3390/ijms231911908

Cited by 15 publications

(9 citation statements)

References 141 publications

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“…However, how TG-C induces an M2 macrophage-dominant microenvironment through TGF-β signaling was not mentioned in this study. 92 Mitogen-Activated Protein Kinase Signaling Pathway Mitogen-activated protein kinase (MAPK) signaling pathways play a crucial role in human diseases, including inflammation and cancer, 93 which are cascade reactions of three kinases. Initially, the most upstream kinase (MAPKKK) receives various extracellular and intracellular signals and activates the middle kinase (MAPKK) through direct phosphorylation.…”

Section: Transforming Growth Factor β Signaling Pathwaymentioning

confidence: 99%

“…Mitogen‐activated protein kinase (MAPK) signaling pathways play a crucial role in human diseases, including inflammation and cancer, 93 which are cascade reactions of three kinases. Initially, the most upstream kinase (MAPKKK) receives various extracellular and intracellular signals and activates the middle kinase (MAPKK) through direct phosphorylation.…”

Section: Signaling Pathways In Macrophage Polarizationmentioning

confidence: 99%

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Emerging Roles of Macrophage Polarization in Osteoarthritis: Mechanisms and Therapeutic Strategies

Yuan,

Jiang,

Yang

et al. 2024

Orthopaedic Surgery

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Osteoarthritis (OA) is the most common chronic degenerative joint disease in middle‐aged and elderly people, characterized by joint pain and dysfunction. Macrophages are key players in OA pathology, and their activation state has been studied extensively. Various studies have suggested that macrophages might respond to stimuli in their microenvironment by changing their phenotypes to pro‐inflammatory or anti‐inflammatory phenotypes, which is called macrophage polarization. Macrophages accumulate and become polarized (M1 or M2) in many tissues, such as synovium, adipose tissue, bone marrow, and bone mesenchymal tissues in joints, while resident macrophages as well as other stromal cells, including fibroblasts, chondrocytes, and osteoblasts, form the joint and function as an integrated unit. In this study, we focus exclusively on synovial macrophages, adipose tissue macrophages, and osteoclasts, to investigate their roles in the development of OA. We review recent key findings related to macrophage polarization and OA, including pathogenesis, molecular pathways, and therapeutics. We summarize several signaling pathways in macrophage reprogramming related to OA, including NF‐κB, MAPK, TGF‐β, JAK/STAT, PI3K/Akt/mTOR, and NLRP3. Of note, despite the increasing availability of treatments for osteoarthritis, like intra‐articular injections, surgery, and cellular therapy, the demand for more effective clinical therapies has remained steady. Therefore, we also describe the current prospective therapeutic methods that deem macrophage polarization to be a therapeutic target, including physical stimulus, chemical compounds, and biological molecules, to enhance cartilage repair and alleviate the progression of OA.

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Section: Transforming Growth Factor β Signaling Pathwaymentioning

confidence: 99%

Section: Signaling Pathways In Macrophage Polarizationmentioning

confidence: 99%

Emerging Roles of Macrophage Polarization in Osteoarthritis: Mechanisms and Therapeutic Strategies

Yuan,

Jiang,

Yang

et al. 2024

Orthopaedic Surgery

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“…MAPK pathway plays a role in progression of many diseases including GIT cancers (Fang and Richardson 2005 ; Shen et al 2023 ; Zhang et al 2020 ; Yang and Huang 2015 ; Zheng et al 2011 ; Chan et al 2021 ; Wang et al 2022a ). A recent study has shown that MAPK pathway is involved in SALL4‐mediated prostate cancer progression (Zhou et al 2023 ).…”

Section: Future Perspectivesmentioning

confidence: 99%

SALL4 in gastrointestinal tract cancers: upstream and downstream regulatory mechanisms

Wang,

Jin,

Wang

et al. 2024

Mol Med

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Effective therapeutic targets and early diagnosis are major challenges in the treatment of gastrointestinal tract (GIT) cancers. SALL4 is a well-known transcription factor that is involved in organogenesis during embryonic development. Previous studies have revealed that SALL4 regulates cell proliferation, survival, and migration and maintains stem cell function in mature cells. Additionally, SALL4 overexpression is associated with tumorigenesis. Despite its characterization as a biomarker in various cancers, the role of SALL4 in GIT cancers and the underlying mechanisms are unclear. We describe the functions of SALL4 in GIT cancers and discuss its upstream/downstream genes and pathways associated with each cancer. We also consider the possibility of targeting these genes or pathways as potential therapeutic options for GIT cancers.

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“…Although most of the genome is comprised of ncRNAs that are encoded by “junk DNA,” they were originally considered to lack physiological functions ( Huang et al, 2023 ). However, as the potential roles of lncRNAs in biological processes have been unveiled, the aforementioned notion has gradually changed ( Wang et al, 2022a ). LncRNAs regulate gene expression at various levels, i.e., chromatin, transcriptional, and post-transcriptional levels ( Bhattacharjee et al, 2023 ; Petrone et al, 2023 ).…”

Section: Type and Role Of Wnt Signaling Pathway-related Ncrnas In Pca...mentioning

confidence: 99%

“…Non-coding RNAs (ncRNAs) have been recognized as critical regulatory factors in gene expression and signal transduction in both normal physiology and disease pathogenesis, particularly in PCa ( Ferri et al, 2022 ; Szaflik et al, 2022 ). ncRNAs are known to execute diverse regulatory roles in cellular processes, despite their inability to encode proteins ( Wang et al, 2022a ). Recent studies have elucidated several types of ncRNAs, such as microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), which play key roles in the regulation of the Wnt signaling pathway in PCa ( Goodall and Wickramasinghe, 2021 ; Xue et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Unlocking the role of non-coding RNAs in prostate cancer progression: exploring the interplay with the Wnt signaling pathway

Bu,

Li,

Tian

2023

Front. Pharmacol.

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Prostate cancer (PCa) is one of the most common cancers in males, exhibiting a wide spectrum of clinical manifestations that pose challenges in its diagnosis and treatment. The Wnt signaling pathway, a conserved and complex pathway, is crucial for embryonic development, tissue homeostasis, and various physiological processes. Apart from the classical Wnt/β-catenin signaling pathway, there exist multiple non-classical Wnt signaling pathways, including the Wnt/PCP and Wnt/Ca2+ pathways. Non-coding RNAs (ncRNAs) are involved in the occurrence and development of PCa and the response to PCa treatment. ncRNAs are known to execute diverse regulatory roles in cellular processes, despite their inability to encode proteins. Among them, microRNAs, long non-coding RNAs, and circular RNAs play key roles in the regulation of the Wnt signaling pathway in PCa. Aberrant expression of these ncRNAs and dysregulation of the Wnt signaling pathway are one of the causes of cell proliferation, apoptosis, invasion, migration, and angiogenesis in PCa. Moreover, these ncRNAs affect the characteristics of PCa cells and hold promise as diagnostic and prognostic biomarkers. Herein, we summarize the role of ncRNAs in the regulation of the Wnt signaling pathway during the development of PCa. Additionally, we present an overview of the current progress in research on the correlation between these molecules and clinical features of the disease to provide novel insights and strategies for the treatment of PCa.

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Non-Coding RNA Related to MAPK Signaling Pathway in Liver Cancer

Cited by 15 publications

References 141 publications

Emerging Roles of Macrophage Polarization in Osteoarthritis: Mechanisms and Therapeutic Strategies

Emerging Roles of Macrophage Polarization in Osteoarthritis: Mechanisms and Therapeutic Strategies

SALL4 in gastrointestinal tract cancers: upstream and downstream regulatory mechanisms

Unlocking the role of non-coding RNAs in prostate cancer progression: exploring the interplay with the Wnt signaling pathway

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