Non-Coding RNAs and Adipogenesis

Abstract

Adipogenesis is regarded as an intricate network in which multiple transcription factors and signal pathways are involved. Recently, big efforts have focused on understanding the epigenetic mechanisms and their involvement in the regulation of adipocyte development. Multiple studies investigating the regulatory role of non-coding RNAs (ncRNAs) in adipogenesis have been reported so far, especially lncRNA, miRNA, and circRNA. They regulate gene expression at multiple levels through interactions with proteins, DNA, and RNA. Exploring the mechanism of adipogenesis and developments in the field of non-coding RNA may provide a new insight to identify therapeutic targets for obesity and related diseases. Therefore, this article outlines the process of adipogenesis, and discusses updated roles and mechanisms of ncRNAs in the development of adipocytes.

Long Noncoding RNA 6302 Regulates Chicken Preadipocyte Differentiation by Targeting SLC22A16

“…lncRNAs are important regulatory molecules and actively participate in various biological processes [ 53 , 54 , 55 , 56 ]. The role of lncRNAs in chicken adipocyte differentiation has also attracted the attention of researchers [ 57 , 58 ]. In order to understand the upstream regulatory mechanism of SLC22A16 , this study conducted a joint analysis with our published lncRNA sequencing data and found a positive correlation between LNC6302 and SLC22A16 expression during chicken adipocyte differentiation [ 7 ], with LNC6302 being located adjacent to SLC22A16 .…”