Non-Coding RNAs and Brain Tumors: Insights Into Their Roles in Apoptosis

Tamtaji, Omid Reza; Derakhshan, Maryam; Noshabad, Fatemeh Zahra Rashidi; Razaviyan, Javad; Hadavi, Razie; Jafarpour, Hamed; Jafari, Ameneh; Rajabi, Ali; Hamblin, Michael R.; Mahabady, Mahmood Khaksary; Taghizadieh, Mohammad; Mirzaei, Hamed

doi:10.3389/fcell.2021.792185

Cited by 17 publications

(12 citation statements)

References 149 publications

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“…An individual miRNA may affect the expression of several mRNAs, while several miRNAs could control each mRNA ( Chen et al, 2021a ; Raue et al, 2021 ). MiRNAs perform a vital role in controlling cell proliferation, apoptosis, migration, and differentiation by modulating the expression of their target genes ( Tamtaji et al, 2021 ). Dysregulated miRNA expression is linked with tumor growth, progression, and chemoresistance in many cancers ( Tu et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-383: A tumor suppressor miRNA in human cancer

Jafarzadeh

Noori

Sarrafzadeh

et al. 2022

Front. Cell Dev. Biol.

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Downregulated expression of anti-tumor miR-383 has been found in many kinds of cancer. MiR-383 family members can directly target the 3′-untranslated region (3′-UTR) of the mRNA of some pro-tumor genes to attenuate several cancer-related processes, including cell proliferation, invasion, migration, angiogenesis, immunosuppression, epithelial-mesenchymal transition, glycolysis, chemoresistance, and the development of cancer stem cells, whilst promoting apoptosis. Functionally, miR-383 operates as a tumor inhibitor miRNA in many types of cancer, including breast cancer, hepatocellular carcinoma, gastric cancer, pancreatic cancer, colorectal cancer, esophageal cancer, lung cancer, head and neck cancer, glioma, medulloblastoma, melanoma, prostate cancer, cervical cancer, oral squamous cell carcinoma, thyroid cancer, and B-cell lymphoma. Both pro-tumor and anti-tumor effects have been attributed to miR-383 in ovarian cancer. However, only the pro-tumor effects of miR-383 were reported in cholangiocarcinoma. The restoration of miR-383 expression could be considered a possible treatment for cancer. This review discusses the anti-tumor effects of miR-383 in human cancers, emphasizing their downstream target genes and potential treatment approaches.

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Section: Introductionmentioning

confidence: 99%

MicroRNA-383: A tumor suppressor miRNA in human cancer

Jafarzadeh

Noori

Sarrafzadeh

et al. 2022

Front. Cell Dev. Biol.

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“…MicroRNAs act as key regulators of a wide variety of cellular mechanisms and physiological processes, such as cell cycle progression, cell division, apoptosis and necroptosis (62,62,(94)(95)(96)(97)(98)(99)(100)(101)(102). Recent studies have demonstrated that numerous miRNAs can strongly affect the expression of pro-and antiapoptotic genes, oncogenes, ER stress-and/or necroptosisrelated genes (20,103). Aberrations involving miRNAs implicated in apoptosis or necroptosis could also impact physiological conditions and promote disease, including carcinogenesis and infection diseases (19,(104)(105)(106).…”

Section: N2bmentioning

confidence: 99%

“…Non-coding RNAs (ncRNAs) are transcripts that do not code for proteins, which can be roughly divided into small non-coding RNAs (smaller than 200 nt) and long non-coding RNAs (lncRNAs, longer than 200 nt) (16)(17)(18)(19)(20)(21)(22)(23)(24)(25). NcRNAs account for the majority of transcriptome, interestingly the amount of ncRNAs correlates with organismal complexity (26).…”

Section: Introductionmentioning

confidence: 99%

Non-Coding RNAs and Oral Cancer: Small Molecules With Big Functions

2022

Self Cite

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Oral cancer remains a major public concern with considerable socioeconomic impact in the world. Despite substantial advancements have been made in treating oral cancer, the five-year survival rate for oral cancer remained undesirable, and the molecular mechanisms underlying OSCC carcinogenesis have not been fully understood. Noncoding RNAs (ncRNAs) include transfer RNAs (tRNAs), as well as small RNAs such as microRNAs, and the long ncRNAs such as HOTAIR are a large segment of the transcriptome that do not have apparent protein-coding roles, but they have been verified to play important roles in diverse biological processes, including cancer cell development. Cell death, such as apoptosis, necrosis, and autophagy, plays a vital role in the progression of cancer. A better understanding of the regulatory relationships between ncRNAs and these various types of cancer cell death is therefore urgently required. The occurrence and development of oral cancer can be controlled by increasing or decreasing the expression of ncRNAs, a method which confers broad prospects for oral cancer treatment. Therefore, it is urgent for us to understand the influence of ncRNAs on the development of different modes of oral tumor death, and to evaluate whether ncRNAs have the potential to be used as biological targets for inducing cell death and recurrence of chemotherapy. The purpose of this review is to describe the impact of ncRNAs on cell apoptosis and autophagy in oral cancer in order to explore potential targets for oral cancer therapy.

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“…The lncRNAs are transcripts with a length of ≥200 nucleotides (nt) [ 4 ]. LncRNAs, like messenger RNAs (mRNAs), are transcribed by RNA polymerase II or III, spliced and capped at 5′ ends [ 5 ]. Contrary to mRNAs, lncRNAs are expressed at low levels and in highly spatiotemporal patterns, generally showing poor conservation across species [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Analysis of Long Non-Coding RNA-Mediated Regulatory Networks of Plutella xylostella in Response to Metarhizium anisopliae Infection

Zafar

Huang

et al. 2022

Insects

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Long non-coding RNAs (lncRNAs) represent a diverse class of RNAs that are structurally similar to messenger RNAs (mRNAs) but do not encode proteins. Growing evidence suggests that in response to biotic and abiotic stresses, the lncRNAs play crucial regulatory roles in plants and animals. However, the potential role of lncRNAs during fungal infection has yet to be characterized in Plutella xylostella, a devastating pest of cruciferous crops. In the current study, we performed a strand-specific RNA sequencing of Metarhizium anisopliae-infected (Px36hT, Px72hT) and uninfected (Px36hCK, Px72hCK) P. xylostella fat body tissues. Comprehensive bioinformatic analysis revealed a total of 5665 and 4941 lncRNAs at 36 and 72-hours post-infection (hpi), including 563 (Px36hT), 532 (Px72hT) known and 5102 (Px36hT), 4409 (Px72hT) novel lncRNA transcripts. These lncRNAs shared structural similarities with their counterparts in other species, including shorter exon and intron length, fewer exon numbers, and a lower expression profile than mRNAs. LncRNAs regulate the expression of neighboring protein-coding genes by acting in a cis and trans manner. Functional annotation and pathway analysis of cis-acting lncRNAs revealed their role in several immune-related genes, including Toll, serpin, transferrin, βGRP etc. Furthermore, we identified multiple lncRNAs acting as microRNA (miRNA) precursors. These miRNAs can potentially regulate the expression of mRNAs involved in immunity and development, suggesting a crucial lncRNA–miRNA-mRNA complex. Our findings will provide a genetic resource for future functional studies of lncRNAs involved in P. xylostella immune responses to M. anisopliae infection and shed light on understanding insect host–pathogen interactions.

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Non-Coding RNAs and Brain Tumors: Insights Into Their Roles in Apoptosis

Cited by 17 publications

References 149 publications

MicroRNA-383: A tumor suppressor miRNA in human cancer

MicroRNA-383: A tumor suppressor miRNA in human cancer

Non-Coding RNAs and Oral Cancer: Small Molecules With Big Functions

Analysis of Long Non-Coding RNA-Mediated Regulatory Networks of Plutella xylostella in Response to Metarhizium anisopliae Infection

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