Non-coding RNAs in drug resistance of head and neck cancers: A review

Dai, Fengsheng; Dai, Li; Zheng, Xian; Guo, Yujia; Zhang, Yuliang; Niu, Min; Lü, Yan; Li, Huizheng; Hou, Rui; Wen, Shuxin; Hu, Wanglai; An, Changming; Wu, Yongyan; Gao, Wei

doi:10.1016/j.biopha.2020.110231

Cited by 23 publications

(12 citation statements)

References 206 publications

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“…Furthermore, due to having tissue specific signatures and due to the expression patterns, they demonstrate in tumours, ncRNAs have shown to be promising for the generation of accurate non-invasive biomarkers for prognosis and diagnosis [114]. Most of the ncRNA families have shown to contribute to not only cancer development but can also give rise to chemoresistance [23,26,[125][126][127][128], and the coming sections will describe chemoresistance arising due to these three ncRNAs in relation to CRC.…”

Section: Overview Of Ncrnasmentioning

confidence: 99%

The Mechanistic Roles of ncRNAs in Promoting and Supporting Chemoresistance of Colorectal Cancer

Micallef

Baron

2021

ncRNA

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Colorectal Cancer (CRC) is one of the most common gastrointestinal malignancies which has quite a high mortality rate. Despite the advances made in CRC treatment, effective therapy is still quite challenging, particularly due to resistance arising throughout the treatment regimen. Several studies have been carried out to identify CRC chemoresistance mechanisms, with research showing different signalling pathways, certain ATP binding cassette (ABC) transporters and epithelial mesenchymal transition (EMT), among others to be responsible for the failure of CRC chemotherapies. In the last decade, it has become increasingly evident that certain non-coding RNA (ncRNA) families are involved in chemoresistance. Research investigations have demonstrated that dysregulation of microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) contribute towards promoting resistance in CRC via different mechanisms. Considering the currently available data on this phenomenon, a better understanding of how these ncRNAs participate in chemoresistance can lead to suitable solutions to overcome this problem in CRC. This review will first focus on discussing the different mechanisms of CRC resistance identified so far. The focus will then shift onto the roles of miRNAs, lncRNAs and circRNAs in promoting 5-fluorouracil (5-FU), oxaliplatin (OXA), cisplatin and doxorubicin (DOX) resistance in CRC, specifically using ncRNAs which have been recently identified and validated under in vivo or in vitro conditions.

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Section: Overview Of Ncrnasmentioning

confidence: 99%

The Mechanistic Roles of ncRNAs in Promoting and Supporting Chemoresistance of Colorectal Cancer

Micallef

Baron

2021

ncRNA

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“…MiRNA dysregulation has an important role in modulating the principal mechanisms that induce HNC drug resistance that are currently known. Abnormal miRNA expression can disrupt the expression levels of multiple genes or important cellular pathways, which has a direct impact on the creation of chemotherapy resistance in HNC [ 42 ]. A study by Qin et al clearly validates how the over expression of a miRNA interrupts the prevailing pathways and induce chemoresistance by directing the tumor suppressor genes [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical Theragnostic Relationship between Chemotherapeutic Resistance, and Sensitivity and miRNA Expressions in Head and Neck Cancers: A Systematic Review and Meta-Analysis Protocol

Shaw

Raymond

Senthilnathan

et al. 2021

Genes

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Background: The microRNAs (miRNAs) are small noncoding single-stranded RNAs typically 19–25 nucleotides long and regulated by cellular and epigenetic factors. These miRNAs plays important part in several pathways necessary for cancer development, an altered miRNA expression can be oncogenic or tumor-suppressive. Recent experimental results on miRNA have illuminated a different perspective of the molecular pathogenesis of head and neck cancers. Regulation of miRNA can have a detrimental effect on the efficacy of chemotherapeutic drugs in both neoadjuvant and adjuvant settings. This miRNA-induced chemoresistance can influence the prognosis and survival rate. The focus of the study is on how regulations of various miRNA levels contribute to chemoresistance in head and neck cancer (HNC). Recent findings suggest that up or down-regulation of miRNAs may lead to resistance towards various chemotherapeutic drugs, which may influence the prognosis. Methods: Studies on miRNA-specific chemoresistance in HNC were collected through literary (bibliographic) databases, including SCOPUS, PubMed, Nature, Elsevier, etc., and were systematically reviewed following PRISMA-P guidelines (Preferred Reporting Items for Systematic Review and Meta-analysis Protocol). We evaluated various miRNAs, their up and downregulation, the effect of altered regulation on the patient’s prognosis, resistant cell lines, etc. The data evaluated will be represented in the form of a review and meta-analysis. Discussion: This meta-analysis aims to explore the miRNA-induced chemoresistance in HNC and thus to aid further researches on this topic. PROSPERO registration: CRD42018104657.

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“…The contribution of miRNAs to the development of resistance against CF chemotherapy has been demonstrated [ 60 , 62 ]. The miRNAs mainly affect head and neck cancer (HNC) drug resistance by influencing the expression of target genes and by regulating apoptosis pathways, epithelial–mesenchymal transformation, and cancer stem cells [ 63 ]. The miRNAs play a role in chemotherapeutic resistance in leukemia, and the deregulation of miRNAs is associated with resistance to chemotherapy in leukemia [ 64 ].…”

Section: Micrornamentioning

confidence: 99%

MicroRNAs and Apoptosis in Colorectal Cancer

Wang

2020

IJMS

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Colorectal cancer (CRC) is the third leading cause of cancer death in the world, and its incidence is rising in developing countries. Treatment with 5-Fluorouracil (5-FU) is known to improve survival in CRC patients. Most anti-cancer therapies trigger apoptosis induction to eliminate malignant cells. However, de-regulated apoptotic signaling allows cancer cells to escape this signaling, leading to therapeutic resistance. Treatment resistance is a major challenge in the development of effective therapies. The microRNAs (miRNAs) play important roles in CRC treatment resistance and CRC progression and apoptosis. This review discusses the role of miRNAs in contributing to the promotion or inhibition of apoptosis in CRC and the role of miRNAs in modulating treatment resistance in CRC cells.

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Non-coding RNAs in drug resistance of head and neck cancers: A review

Cited by 23 publications

References 206 publications

The Mechanistic Roles of ncRNAs in Promoting and Supporting Chemoresistance of Colorectal Cancer

The Mechanistic Roles of ncRNAs in Promoting and Supporting Chemoresistance of Colorectal Cancer

Clinical Theragnostic Relationship between Chemotherapeutic Resistance, and Sensitivity and miRNA Expressions in Head and Neck Cancers: A Systematic Review and Meta-Analysis Protocol

MicroRNAs and Apoptosis in Colorectal Cancer

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