Non-coding RNAs: the silent regulators of health and diseases

Abstract

Non-coding RNAs (ncRNAs) like miRNAs, siRNA, lncRNAs, circRNAs, piRNAs, snoRNAs, snRNAs etc. form a collective group of RNAs that is instrumental to the various functions of the genome. With the advent of cutting-edge molecular biology tools and techniques, scientists have unearthed several mechanisms through which these ncRNAs act. Although our understanding may still be limited, yet scientists have been able to establish ncRNAs as major regulators of genetic inter-plays that dictate various pathophysiological conditions. This special issue of Molecular Biology Reports features a collection of research and review articles on ncRNAs and their involvement in different pathophysiological conditions that include different types of cancers. It is expected that this special issue will motivate researchers in the field to delve deeper into the world of ncRNAs and attempt to develop new diagnostic and therapeutic interventions for challenging clinical conditions.

PIWIL1 is recruited to Centrosomes during Mitosis in Colorectal Cancer Cells and is linked to cell cycle progression

“…Wound Healing Assays. 1x10 4 Caco-2 and PIWIL1 knockdown Caco-2 cells were grown in 24-well plates. After the cells have become con uent we performed a cell-free gap in the monolayer by mechanical scratching (scratch wound) with a white sterile pipet tip.…”

“…Notably, PIWIL1, a key component of piRNA-mediated gene expression regulation pathways, has gathered attention for its suspected role as an oncogene since 2002, when it was rst reported to be overexpressed in seminoma (a testicular-derived tumor) [3]. Nowadays, overexpression of different PIWI proteins has been frequently observed in a variety of cancers, including gastric cancer, sarcoma, esophageal squamous cell carcinoma, endometrial cancer, colon cancer, cervical cancer, glioma, hepatocellular carcinoma, ovarian cancer, breast cancer, bladder cancer, and renal cell carcinoma [4]. Nevertheless, the mechanisms underlying PIWI protein overexpression and their impact on the initiation and progression of cancer remain elusive.…”

PIWIL1 is recruited to Centrosomes during Mitosis in Colorectal Cancer Cells and is linked to cell cycle progression

“…Notably, PIWIL1, a key component of piRNA-mediated gene expression regulation pathways, has gathered attention for its suspected role as an oncogene since 2002, when it was first reported to be overexpressed in seminoma (a testicular-derived tumor) (Qiao et al, 2002). Nowadays, overexpression of different PIWI proteins has been frequently observed in a variety of cancers, including gastric cancer, sarcoma, esophageal squamous cell carcinoma, endometrial cancer, colon cancer, cervical cancer, glioma, hepatocellular carcinoma, ovarian cancer, breast cancer, bladder cancer, and renal cell carcinoma (Chakravorty, 2022). Nevertheless, the mechanisms underlying PIWI protein overexpression and their impact on the initiation and progression of cancer remain elusive.…”