Non-enzymatic nitric oxide release from biodegradable S-nitrosothiol bound polymer: synthesis, characterization, and antibacterial effect

Sundari, S.; Berchmans, Sheela; Umadevi, S.

doi:10.1007/s00289-017-2199-4

Cited by 4 publications

(4 citation statements)

References 45 publications

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“…[164] NO donor coupling with the biodegradable polymer poly(acrylic acid) aids NO's stability and storage. [165] Instead of coating NO donor alone, simultaneously grafting dihydropyrrolones DHPs (an inhibitor of intercellular communication system in bacteria termed quorum sensing [166] ) and NO donor NONOate onto coated fluorinated ethylene propylene surface can significantly reduce bacterial adhesion. [167] To date, a wide range of NO-releasing macromolecular scaffolds have proven effectively against bacteria.…”

Section: Killing Of Pathogenic Bacteriamentioning

confidence: 99%

Polymeric Nitric Oxide Delivery Nanoplatforms for Treating Cancer, Cardiovascular Diseases, and Infection

Jin

Gao

Liu

et al. 2020

Adv Healthcare Materials

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The shortened Abstract is as follows: Therapeutic gas nitric oxide (NO) has demonstrated the unique advances in biomedical applications due to its prominent role in regulating physiological/pathophysiological activities in terms of vasodilation, angiogenesis, chemosensitizing effect, and bactericidal effect. However, it is challenging to deliver NO, due to its short half-life (<5 s) and short diffusion distances (20-160 µm). To address these, various polymeric NO delivery nanoplatforms (PNODNPs) have been developed for cancer therapy, antimicrobial and cardiovascular therapeutics, because of the important advantages of polymeric delivery nanoplatforms in terms of controlled release of therapeutics and the extremely versatile nature. This reviews highlights the recent significant advances made in PNODNPs for NO storing and targeting delivery. The ideal and unique criteria that are required for PNODNPs for treating cancer, cardiovascular diseases and infection, respectively, are summarized. Hopefully, effective storage and targeted delivery of NO in a controlled manner using PNODNPs could pave the way for NO-sensitized synergistic therapy in clinical practice for treating the leading death-causing diseases.

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Section: Killing Of Pathogenic Bacteriamentioning

confidence: 99%

Polymeric Nitric Oxide Delivery Nanoplatforms for Treating Cancer, Cardiovascular Diseases, and Infection

Jin

Gao

Liu

et al. 2020

Adv Healthcare Materials

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“…IR spectra of PAA-SH showed a band at 2550 cm −1 , corresponding to -SH stretching. [36,37] This band disappeared after S-nitrosation in the spectrum of PAA-SNO. Previous studies confirmed the presence of SNO through the formation of an S-N stretching band at 1567 cm −1 .…”

Section: Design Of No-releasing Cell Coatingmentioning

confidence: 95%

“…Synthesis of Thiol-Functionalized PAA: Thiol-functionalized PAA was synthesized by modifying the previously reported method. [37] The polymer solution was prepared at 0.43 m in 0.1 m NaHCO 2 and in 0.1 m Na 2 CO 3 buffer at pH 8.5. EDC was added to the solution with an equal molar ratio with PAA and stirred for 10 min.…”

Section: Methodsmentioning

confidence: 99%

“…Synthesis of PAA-SNO: SNO-containing PAA (PAA-SNO) were synthesized based on the thiol-functionalized PAA based on the previously described method. [37,59] Moreover, the nitrosation of thiol was performed at 0 °C in the dark to prevent harmful organic nitrite reactions in polyester materials. Furthermore, 0.292 g of thiol-functionalized PAA was dissolved in 6 mL of distilled water, and an equal molar ratio of sodium nitrite (NaNO 2 ) was added to the solution.…”

Section: Methodsmentioning

confidence: 99%

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A Nanocoating Co‐Localizing Nitric Oxide and Growth Factor onto Individual Endothelial Cells Reveals Synergistic Effects on Angiogenesis

Jeong

Choi

et al. 2021

Adv Healthcare Materials

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The delivery of nitric oxide (NO)-an intrinsic cellular signaling molecule-is promising for disease treatment, in particular to vascular diseases, due to its endothelial-derived inherent nature. The limited diffusion distance of labile NO prompts researchers to develop various carriers and targeting methods for specific sites. In contrast to the apoptotic effect of NO, such as anticancer, delivering low NO concentration at the desired targeting area is still intricate in a physiological environment. In this study, the layer-by-layer assembled nanocoating is leveraged to develop a direct NO delivery platform to individual endothelial cells (ECs). NO can be localized to individual ECs via S-nitrosothiol-bound polyacrylic acid which is a polymer directly providing an endothelial-like constant level of NO. To increase angiogenic activation along with NO, VEGF is additionally applied to specific receptors on the cell surface. Notably, the survival and proliferation of ECs are significantly increased by a synergistic effect of NO and VEGF co-localized via nanocoating. Furthermore, the nanocoating remarkably promoted cell migration and tubule formation-prerequisites of angiogenesis. The proposed unique technology based on nanocoating demonstrates great potential for conferring desired angiogenic functions to individual ECs through efficient NO delivery.

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Bioinorganic systems responsive to the diatomic gases O2, NO, and CO: From biological sensors to therapy

Lopes

Júnior

Holanda

et al. 2021

Coordination Chemistry Reviews

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Non-enzymatic nitric oxide release from biodegradable S-nitrosothiol bound polymer: synthesis, characterization, and antibacterial effect

Cited by 4 publications

References 45 publications

Polymeric Nitric Oxide Delivery Nanoplatforms for Treating Cancer, Cardiovascular Diseases, and Infection

Polymeric Nitric Oxide Delivery Nanoplatforms for Treating Cancer, Cardiovascular Diseases, and Infection

A Nanocoating Co‐Localizing Nitric Oxide and Growth Factor onto Individual Endothelial Cells Reveals Synergistic Effects on Angiogenesis

Bioinorganic systems responsive to the diatomic gases O2, NO, and CO: From biological sensors to therapy

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